Heterogeneity Among Poor Ovarian Responders According to Bologna Criteria Results in Diverging Cumulative Live Birth Rates

Abstract Background Recently, some studies evaluated the live births rates (LBRs) in two poor ovarian responders (POR) classification methods separately, but present study was designed to compare the LBRs among different groups of patients on the basis of Bologna criteria or POSIEDON group classifications and find the important predictive factors for LBR in patients with POR.Methods In this cross-sectional study, the database containing clinical and laboratory information on infertility treatment cycles were evaluated from December 2015 to December 2017 and all the patients with at least one POR after standard controlled ovarian stimulation (COH) during IVF/ICSI cycles were evaluated. The eligible patients were enrolled and divided into five and four groups according to the Bologna criteria and POSEIDON groups’ classifications, respectively.Results 812 patients with POR diagnosis were investigated which in overall 517 of them had embryo transfer in the last treatment cycle (63.6%) and total clinical pregnancy rate 19.3% (100 cases) and live birth rates 16.1% (86 cases) were found. When the patients were grouped on the Basis of the POSEIDON classification, the highest LBR was observed in the POSEIDON group III. On the other hand, according to the Bologna criteria, 41 patients were not included in any group, and in the analysis of cycle outcome, the LBR in the Bologna group II was more than other groups. The multivariable regression analysis revealed that the significant independent variables remained in the model as important predictive factor for live births in the study population were the number and quality of the transferred embryos transmission (good and excellent quality), and the POSSIDON classification group (POSSIDON group III).ConclusionsOn the basis of present results, the POSEIDON group classification could be more comprehensive and practical than Bologna criteria for diagnosing and categorizing POR patients. In addition, it was found the number and quality of transferred embryos were the most important prognostic factor for live birth in POR patients; therefore we suggest to consider COH protocols with a freezing embryos strategy, and the collection of more good quality embryos to improve the probability of a live birth.

Download Full-text

Live birth rates in different subgroups of poor ovarian responders according to Bologna criteria and POSEIDON group classification

10.21203/rs.3.rs-16752/v1 ◽

2020 ◽

Author(s):

Mehri Mashayekhy ◽

Forouzan Barabi ◽

Arezoo Arabipoor ◽

Zahra Zolfaghari

Keyword(s):

Live Birth ◽

Group Classification ◽

Birth Rates ◽

Cross Sectional ◽

Group Iii ◽

Live Births ◽

Bologna Criteria ◽

Live Birth Rates ◽

Poor Ovarian Responders

Abstract Background Recently, some studies evaluated the live births rates (LBRs) in two poor ovarian responders (POR) classification methods separately, but present study was designed to compare the LBRs among different groups of patients on the basis of Bologna criteria or POSIEDON group classifications and find the important predictive factors for LBR in patients with POR. Methods In this cross-sectional study, the database containing clinical and laboratory information on infertility treatment cycles were evaluated from December 2015 to December 2017 and all the patients with at least one POR after standard controlled ovarian stimulation (COH) during IVF/ICSI cycles were evaluated. The eligible patients were enrolled and divided into five and four groups according to the Bologna criteria and POSEIDON groups’ classifications, respectively. Results 812 patients with POR diagnosis were investigated which in overall 517 of them had embryo transfer in the last treatment cycle (63.6%) and total clinical pregnancy rate 19.3% (100 cases) and live birth rates 16.1% (86 cases) were found. When the patients were grouped on the Basis of the POSEIDON classification, the highest LBR was observed in the POSEIDON group III. On the other hand, according to the Bologna criteria, 41 patients were not included in any group, and in the analysis of cycle outcome, the LBR in the Bologna group II was more than other groups. The multivariable regression analysis revealed that the significant independent variables remained in the model as important predictive factor for live births in the study population were the number and quality of the transferred embryos transmission (good and excellent quality), and the POSSIDON classification group (POSSIDON group III). Conclusions On the basis of present results, the POSEIDON group classification could be more comprehensive and practical than Bologna criteria for diagnosing and categorizing POR patients. In addition, it was found the number and quality of transferred embryos were the most important prognostic factor for live birth in POR patients; therefore we suggest to consider COH protocols with a freezing embryos strategy, and the collection of more good quality embryos to improve the probability of a live birth.

Download Full-text

Live birth rates in the different combinations of the Bologna criteria poor ovarian responders: a validation study

Journal of Assisted Reproduction and Genetics ◽

10.1007/s10815-015-0476-4 ◽

2015 ◽

Vol 32 (6) ◽

pp. 931-937 ◽

Cited By ~ 47

Author(s):

Antonio La Marca ◽

Valentina Grisendi ◽

Simone Giulini ◽

Giovanna Sighinolfi ◽

Alessandra Tirelli ◽

...

Keyword(s):

Live Birth ◽

Validation Study ◽

Birth Rates ◽

Bologna Criteria ◽

Live Birth Rates ◽

Poor Ovarian Responders

Download Full-text

Cumulative Live Birth Rates Following Stimulation With Corifollitropin Alfa Compared With hp-hMG in a GnRH Antagonist Protocol in Poor Ovarian Responders

Frontiers in Endocrinology ◽

10.3389/fendo.2019.00175 ◽

2019 ◽

Vol 10 ◽

Cited By ~ 7

Author(s):

Joaquín Errázuriz ◽

Alessia Romito ◽

Panagiotis Drakopoulos ◽

Billie Frederix ◽

Analissa Racca ◽

...

Keyword(s):

Live Birth ◽

Gnrh Antagonist ◽

Birth Rates ◽

Live Birth Rates ◽

Cumulative Live Birth ◽

Corifollitropin Alfa ◽

Poor Ovarian Responders ◽

Gnrh Antagonist Protocol ◽

Antagonist Protocol

Download Full-text

Live birth rates in various subgroups of poor ovarian responders fulfilling the Bologna criteria

Reproductive BioMedicine Online ◽

10.1016/j.rbmo.2017.03.009 ◽

2017 ◽

Vol 34 (6) ◽

pp. 639-644 ◽

Cited By ~ 25

Author(s):

Gurkan Bozdag ◽

Mehtap Polat ◽

Irem Yarali ◽

Hakan Yarali

Keyword(s):

Live Birth ◽

Birth Rates ◽

Bologna Criteria ◽

Live Birth Rates ◽

Poor Ovarian Responders

Download Full-text

Cumulative live birth rates in in-vitro fertilization

Minerva Ginecologica ◽

10.23736/s0026-4784.18.04347-2 ◽

2019 ◽

Vol 71 (3) ◽

Cited By ~ 5

Author(s):

Panagiotis Drakopoulos ◽

Joaquín Errázuriz ◽

Samuel Santos-Ribeiro ◽

Herman Tournaye ◽

Alberto Vaiarelli ◽

...

Keyword(s):

In Vitro Fertilization ◽

Live Birth ◽

Birth Rates ◽

Vitro Fertilization ◽

Live Birth Rates ◽

Cumulative Live Birth

Download Full-text

Sperm Selection by Magnetic-Activated Cell Sorting Before Microinjection of Autologous Oocytes Increases Cumulative Live Birth Rates with Limited Clinical Impact: A Retrospective Study in Unselected Males

Biology ◽

10.3390/biology10050430 ◽

2021 ◽

Vol 10 (5) ◽

pp. 430

Author(s):

María Gil Juliá ◽

Irene Hervás ◽

Ana Navarro-Gómez Lechón ◽

Fernando Quintana ◽

David Amorós ◽

...

Keyword(s):

Live Birth ◽

Clinical Impact ◽

Sperm Selection ◽

Reproductive Outcomes ◽

Birth Rates ◽

Multicenter Observational Study ◽

Live Birth Rates ◽

Cumulative Live Birth ◽

The Impact ◽

Autologous Oocytes

The application of MACS non-apoptotic sperm selection in infertility clinics is controversial since the published literature does not agree on its effect on reproductive outcomes. Therefore, it is not part of the routine clinical practice. Classical measures of reproductive success (pregnancy or live birth rates per ovarian stimulation) introduce a bias in the evaluation of a technique’s effect, since only the best embryo is transferred. This retrospective, multicenter, observational study evaluated the impact of MACS on reproductive outcomes, measuring results in classical parameters and cumulative live birth rates (CLBR). Data from ICSI cycles using autologous oocyte in Spanish IVIRMA fertility clinics from January 2008 to February 2020 were divided into two groups according to their semen processing: standard practice (reference: 46,807 patients) versus an added MACS sperm selection (1779 patients). Only when measured as CLBR per embryo transferred and per MII oocyte used was the difference between groups statistically significant. There were no significant differences between MACS and reference groups on pregnancy and live birth rates. In conclusion, results suggest that non-apoptotic sperm selection by MACS on unselected males prior to ICSI with autologous oocytes has limited clinical impact, showing a subtle increase in CLBR per embryo transferred.

Download Full-text