scholarly journals Cardiovascular Implications in Idiopathic and Syndromic Obesity in Childhood: An Update

2020 ◽  
Vol 11 ◽  
Author(s):  
Maurizio Delvecchio ◽  
Carmela Pastore ◽  
Federica Valente ◽  
Paola Giordano
Keyword(s):  
Syndromic Obesity

scholarly journals MIR137 is the key gene mediator of the syndromic obesity phenotype of patients with 1p21.3 microdeletions

2016 ◽  
Vol 9 (1) ◽  
Author(s):  
Arianna Tucci ◽  
Claudia Ciaccio ◽  
Giulietta Scuvera ◽  
Susanna Esposito ◽  
Donatella Milani
Keyword(s):  
Syndromic Obesity ◽  
Obesity Phenotype

scholarly journals Clinical, molecular genetics and therapeutic aspects of syndromic obesity

2018 ◽  
Vol 95 (1) ◽  
pp. 23-40 ◽  
Author(s):  
E. Geets ◽  
M.E.C. Meuwissen ◽  
W. Van Hul
Keyword(s):  
Molecular Genetics ◽  
Syndromic Obesity ◽  
Clinical Molecular Genetics

Liraglutide for weight management in syndromic obesity: effects in overgrowth adult Beckwith–Wiedemann syndrome

2021 ◽  
Author(s):  
Marina Caputo ◽  
Tommaso Daffara ◽  
Simonetta Bellone ◽  
Valentina Mancioppi ◽  
Paolo Marzullo ◽  
...  
Keyword(s):  
Weight Management ◽  
Syndromic Obesity

Genomic study via chromosomal microarray analysis in a group of Romanian patients with obesity and developmental disability/intellectual disability

2019 ◽  
Vol 32 (7) ◽  
pp. 667-674 ◽  
Author(s):  
Diana Micleaa ◽  
Camelia Al-Khzouza ◽  
Sergiu Osan ◽  
Simona Bucerzan ◽  
Victoria Cret ◽  
...  
Keyword(s):  
Intellectual Disability ◽  
Developmental Disability ◽  
Snp Array ◽  
Uniparental Disomy ◽  
Genomic Analysis ◽  
Chromosomal Microarray ◽  
Chromosomal Microarray Analysis ◽  
Syndromic Obesity ◽  
Genomic Study ◽  
Array Technology

Abstract Background Obesity with developmental disability/intellectual disability (DD/ID) is the most common association in syndromic obesity. Genomic analysis studies have allowed the decipherment of disease aetiology, both in cases of syndromic obesity as well as in cases of isolated or syndromic DD/ID. However, more data are needed to further elucidate the link between the two. The aim of this pangenomic study was to use single nucleotide polymorphism (SNP) array technology to determine the copy number variant (CNV) type and frequency associated with both obesity and DD/ID. Methods Thirty-six patients were recruited from the Clinical Emergency Hospital for Children, in Cluj-Napoca, Romania during the period 2015–2017. The main inclusion criterion was a diagnosis that included both obesity and DD/ID. Genomic analysis via SNP array technology was performed. Results Out of the 36 patients, 12 (33%) presented CNVs with a higher degree of pathogenicity (A group) and 24 (66%) presented benign CNVs (B group). The SNP array results for the A group were as follows: pathogenic CNVs in 8/12 patients (67%); variants of unknown significance (VOUS) in 2/12 patients (16%); and uniparental disomy (UPD) in 2/12 patients (16%). Conclusions Some of these CNVs have already been observed in patients with both obesity and DD/ID, but the others were noticed only in DD/ID patients and have not been described until now in association with obesity.

scholarly journals Chromosomal microarray analysis in the genetic evaluation of 279 patients with syndromic obesity

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Carla Sustek D’Angelo ◽  
Monica Castro Varela ◽  
Claudia Irene Emílio de Castro ◽  
Paulo Alberto Otto ◽  
Ana Beatriz Alvarez Perez ◽  
...  
Keyword(s):  
Microarray Analysis ◽  
Genetic Evaluation ◽  
Chromosomal Microarray ◽  
Chromosomal Microarray Analysis ◽  
Syndromic Obesity

Cytokine Responses to Acute Intermittent Aerobic Exercise in Children with Prader-Willi Syndrome and Nonsyndromic Obesity

2015 ◽  
Vol 27 (4) ◽  
pp. 525-534 ◽  
Author(s):  
Andrea T. Duran ◽  
Erik Gertz ◽  
Daniel A. Judelson ◽  
Andrea M. Haqq ◽  
Susan J. Clark ◽  
...  
Keyword(s):  
Aerobic Exercise ◽  
Body Fat ◽  
Acute Exercise ◽  
Area Under The Curve ◽  
Low Grade ◽  
Prader Willi Syndrome ◽  
Cytokine Responses ◽  
Syndromic Obesity ◽  
Tnf Α ◽  
Children Obesity

Prader-Willi Syndrome (PWS), the best characterized form of syndromic obesity, presents with abnormally high fat mass. In children, obesity presents with low-grade systemic inflammation. This study evaluated if PWS and/or nonsyndromic obesity affected cytokine responses to intermittent aerobic exercise in children. Eleven children with PWS (11 ± 2 y, 45.4 ± 9.5% body fat), 12 children with obesity (OB) (9 ± 1 y, 39.9 ± 6.8% body fat), and 12 lean (LN) children (9 ± 1 y, 17.5 ± 4.6% body fat) participated. Children completed 10 2-min cycling bouts of vigorous intensity, separated by 1-min rest. Blood samples were collected preexercise (PRE), immediately postexercise (IP), and 15, 30, and 60 min into recovery to analyze possible changes in cytokines. In all groups, IL-6 and IL-8 concentrations were greater during recovery compared with PRE. PWS and OB exhibited higher IL-6 area under the curve (AUC) than LN (p < .01 for both). PWS demonstrated higher IL-8 AUC than LN (p < .04). IL-10, TNF-α, and IFN-γ did not change with exercise (p > .05 for all). Results indicate that children with PWS respond with increased Il-6 and IL-8 concentrations to acute exercise similarly to controls. Excess adiposity and epigenetic modifications may explain the greater integrated IL-6 and IL-8 responses in PWS compared with controls.

scholarly journals Laparoscopic sleeve gastrectomy in adolescents with or without syndromic obesity: two years follow-up

2017 ◽  
Vol 23 (4) ◽  
pp. 479-486 ◽  
Author(s):  
Angelo Iossa ◽  
Francesco De Peppo ◽  
Romina Caccamo ◽  
Brad Michael Watkins ◽  
Francesca Abbatini ◽  
...  
Keyword(s):  
Sleeve Gastrectomy ◽  
Laparoscopic Sleeve Gastrectomy ◽  
Syndromic Obesity
Sign in / Sign up

Export Citation Format

Share Document