Corrigendum: MiR-29a Knockout Aggravates Neurological Damage by Pre-polarizing M1 Microglia in Experimental Rat Models of Acute Stroke

ObjectiveBy exploring the effects of miR-29a-5p knockout on neurological damage after acute ischemic stroke, we aim to deepen understanding of the molecular mechanisms of post-ischemic injury and thus provide new ideas for the treatment of ischemic brain injury.MethodsmiR-29a-5p knockout rats and wild-type SD rats were subjected to transient middle cerebral artery occlusion (MCAO). miR-29a levels in plasma, cortex, and basal ganglia of ischemic rats, and in plasma and neutrophils of ischemic stroke patients, as well as hypoxic glial cells were detected by real-time PCR. The infarct volume was detected by TTC staining and the activation of astrocytes and microglia was detected by western blotting.ResultsThe expression of miR-29a-5p was decreased in parallel in blood and brain tissue of rat MCAO models. Besides, miR-29a-5p levels were reduced in the peripheral blood of acute stroke patients. Knockout of miR-29a enhanced infarct volume of the MCAO rat model, and miR-29a knockout showed M1 polarization of microglia in the MCAO rat brain. miR-29a knockout in rats after MCAO promoted astrocyte proliferation and increased glutamate release.ConclusionKnockout of miR-29a in rats promoted M1 microglial polarization and increased glutamate release, thereby aggravating neurological damage in experimental stroke rat models.

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Changes in Functional Independence of Patients with Acute Stroke during Treatment

Reabilitacijos mokslai slauga kineziterapija ergoterapija ◽

10.33607/rmske.v1i14.700 ◽

2019 ◽

Vol 1 (14) ◽

Author(s):

Lina Samuolienė ◽

Vida Mockienė

Keyword(s):

Ischemic Stroke ◽

Acute Stroke ◽

Older Patients ◽

Intravenous Thrombolysis ◽

Functional Independence ◽

The State ◽

High Morbidity ◽

Index Test ◽

Neurological Damage ◽

Neurological State

Background. Ischemic stroke (IS) is one of the most topical medical and social problems because of high morbidity and severe residual disability. The goal of the research was to analyze inﬂuencing changes in the independence of patients with acute stroke during treatment. Methods included the retrospective research, carried out in September 2015– November, 2015, using Barthel Index test (BI), National Institute of Health Stroke Scale (NIHSS) and modifed Rankin scale (mRS). The research sample was 104 respondents, 48 of which underwent treatment with intravenous thrombolysis (IVT), and 56 of them – not. Research fndings were processed using statistical “SPSS 17 for Windows” package. The research was carried out complying with the ethical principles. Results. Treatment by intravenous thrombolysis was applied to approximately half of IS patients. The majority of IS patients were of average severity state by neurological damage. There neurological state after the thrombolysis improved the state of 50% of patients on average in seven days. Half of IS patients were completely dependent before treatment and after the treatment the number of absolutely dependent patients decreased by 21.3%. The independence of patients treated by intravenous thrombolysis and non-treated did not vary signifcantly at the beginning and the end of the treatment, however, its change was insignifcantly higher for the patients to whom this treatment was applied than for the patients to whom this treatment was not applied. The independence before the treatment was higher of men than of women, and of the patients under 65 years old than of older patients. The change of independence was higher for patients under 65 years old than for the older ones, and there was no signifcant difference between men and women. Conclusions. The treatment by intravenous thrombolysis was applied to approximately half of the patients. The neurological damage was more severe for those who were 65 years old. After the treatment the state recovered for 9.6% and those were only men, the number of absolutely dependent persons decreased by 21.3%. Keywords: ischemic stroke, during treatment patients, independence.

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The role of nursing in the rehabilitation of acute stroke patients: Toward a unified theoretical perspective

Pflege ◽

10.1024/1012-5302.12.1.21 ◽

1999 ◽

Vol 12 (1) ◽

pp. 21-27

Author(s):

Marit Kirkevold

Keyword(s):

Acute Stroke ◽

Theoretical Perspective ◽

Stroke Patients ◽

Role Of Nursing ◽

Rolle Der Pflegenden

Eine Übersicht der bestehenden Literatur weist auf Unsicherheiten bezüglich der spezifischen Rolle der Pflegenden in der Rehabilitation von Hirnschlagpatientinnen und -patienten hin. Es existieren zwei unterschiedliche Begrifflichkeiten für die Rolle der Pflegenden, keine davon bezieht sich auf spezifische Rehabilitationsziele oder Patientenergebnisse. Ein anfänglicher theoretischer Beitrag der Rolle der Pflege in der Genesung vom Hirnschlag wird als Struktur unterbreitet, um die therapeutischen Aspekte der Pflege im Koordinieren, Erhalten und Üben zu vereinen. Bestehende Literatur untermauert diesen Beitrag. Weitere Forschung ist jedoch notwendig, um den spezifischen Inhalt und Fokus der Pflege in der Genesung bei Hirnschlag zu entwickeln.

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