scholarly journals Vasculature-Associated Lymphoid Tissue: A Unique Tertiary Lymphoid Tissue Correlates With Renal Lesions in Lupus Nephritis Mouse Model

2020 ◽  
Vol 11 ◽  
Author(s):  
Md. Abdul Masum ◽  
Osamu Ichii ◽  
Yaser Hosny Ali Elewa ◽  
Yuki Otani ◽  
Takashi Namba ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Immune Cells ◽  
Lymphoid Tissue ◽  
Young Patients ◽  
Chemokine Production ◽  
Tertiary Lymphoid Tissue ◽  
Renal Lesions ◽  
Tissue Organization ◽  
Lymphocyte Activity ◽  
Center Activity

Lupus nephritis (LN) is a common complication in young patients and the most predominant cause of glomerulonephritis. Infiltrating immune cells and presence of immunocomplexes in the kidney are hallmarks of LN, which is closely associated with renal lesions (RLs). However, their regulatory mechanism in the kidney remains unclear, which is valuable for prevention of RL development. Here, we show the development of vasculature-associated lymphoid tissue (VALT) in LN, which is related to renal inflammatory cytokines, indicating that VALT is a unique tertiary lymphoid tissue. Transcriptomic analysis revealed different chemokines and costimulatory molecules for VALT induction and organization. Vascular and perivascular structures showed lymphoid tissue organization through lymphorganogenic chemokine production. Transcriptional profile and intracellular interaction also demonstrated antigen presentation, lymphocyte activity, clonal expansion, follicular, and germinal center activity in VALT. Importantly, VALT size was correlated with infiltrating immune cells in kidney and RLs, indicating its direct correlation with the development of RLs. In addition, dexamethasone administration reduced VALT size. Therefore, inhibition of VALT formation would be a novel therapeutic strategy against LN.

scholarly journals Developmental stages of tertiary lymphoid tissue reflect local injury and inflammation in mouse and human kidneys

2020 ◽  
Vol 98 (2) ◽  
pp. 448-463 ◽  
Author(s):  
Yuki Sato ◽  
Peter Boor ◽  
Shingo Fukuma ◽  
Barbara M. Klinkhammer ◽  
Hironori Haga ◽  
...  
Keyword(s):  
Lymphoid Tissue ◽  
Developmental Stages ◽  
Tertiary Lymphoid Tissue ◽  
Local Injury

Effects of Plasmapheresis on Renal Lesions in Lupus Nephritis

2015 ◽  
pp. 384-389
Author(s):  
V. Bonomini ◽  
A. Vangelista ◽  
G. Frasc� ◽  
A. Bonifati ◽  
A. Buscaroli ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Renal Lesions

scholarly journals P189 Antiphospholipid antibodies and vascular renal lesions as prognostic factors in lupus nephritis

2020 ◽  
Author(s):  
Annamaria Paglionico ◽  
Valentina Varriano ◽  
Luca Petricca ◽  
Clara Di Marioa ◽  
Maria Rita Gigante ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lupus Nephritis ◽  
Antiphospholipid Antibodies ◽  
Renal Lesions

scholarly journals Enhancement of immune response against Bordetella spp. by disrupting immunomodulation

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Monica C. Gestal ◽  
Laura K. Howard ◽  
Kalyan Dewan ◽  
Hannah M. Johnson ◽  
Mariette Barbier ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Immune Cells ◽  
Lymphoid Tissue ◽  
Protective Immunity ◽  
Inflammatory Cells ◽  
Host Immune System ◽  
Initial Growth ◽  
Wild Type ◽  
Sterilizing Immunity

AbstractWell-adapted pathogens must evade clearance by the host immune system and the study of how they do this has revealed myriad complex strategies and mechanisms. Classical bordetellae are very closely related subspecies that are known to modulate adaptive immunity in a variety of ways, permitting them to either persist for life or repeatedly infect the same host. Exploring the hypothesis that exposure to immune cells would cause bordetellae to induce expression of important immunomodulatory mechanisms, we identified a putative regulator of an immunomodulatory pathway. The deletion of btrS in B. bronchiseptica did not affect colonization or initial growth in the respiratory tract of mice, its natural host, but did increase activation of the inflammasome pathway, and recruitment of inflammatory cells. The mutant lacking btrS recruited many more B and T cells into the lungs, where they rapidly formed highly organized and distinctive Bronchial Associated Lymphoid Tissue (BALT) not induced by any wild type Bordetella species, and a much more rapid and strong antibody response than observed with any of these species. Immunity induced by the mutant was measurably more robust in all respiratory organs, providing completely sterilizing immunity that protected against challenge infections for many months. Moreover, the mutant induced sterilizing immunity against infection with other classical bordetellae, including B. pertussis and B. parapertussis, something the current vaccines do not provide. These findings reveal profound immunomodulation by bordetellae and demonstrate that by disrupting it much more robust protective immunity can be generated, providing a pathway to greatly improve vaccines and preventive treatments against these important pathogens.

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