scholarly journals Phenotyping of Adaptive Immune Responses in Inflammatory Diseases

2020 ◽  
Vol 11 ◽  
Author(s):  
Jens Y. Humrich ◽  
Joana P. Bernardes ◽  
Ralf J. Ludwig ◽  
David Klatzmann ◽  
Alexander Scheffold
Keyword(s):  
Immune Responses ◽  
Precision Medicine ◽  
Inflammatory Diseases ◽  
Treatment Strategies ◽  
Cellular Level ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Challenges And Opportunities ◽  
Recent Developments

Immunophenotyping on the molecular and cellular level is a central aspect for characterization of patients with inflammatory diseases, both to better understand disease etiopathogenesis and based on this to develop diagnostic and prognostic biomarkers which allow patient stratification and tailor-made treatment strategies. Technology-driven developments have considerably expanded the range of analysis tools. Especially the analysis of adaptive immune responses, often regarded as central though mostly poorly characterized disease drivers, is a major focus of personalized medicine. The identification of the disease-relevant antigens and characterization of corresponding antigen-specific lymphocytes in individual patients benefits significantly from recent developments in cytometry by sequencing and proteomics. The aim of this workshop was to identify the important developments for state-of-the-art immunophenotyping for clinical application and precision medicine. We focused here on recent key developments in analysis of antigen-specific lymphocytes, sequencing, and proteomics approaches, their relevance in precision medicine and the discussion of the major challenges and opportunities for the future.

scholarly journals Characterization of Human Antiviral Adaptive Immune Responses during Hepatotropic Virus Infection in HLA-Transgenic Human Immune System Mice

2013 ◽  
Vol 191 (4) ◽  
pp. 1753-1764 ◽  
Author(s):  
Eva Billerbeck ◽  
Joshua A. Horwitz ◽  
Rachael N. Labitt ◽  
Bridget M. Donovan ◽  
Kevin Vega ◽  
...  
Keyword(s):  
Immune System ◽  
Virus Infection ◽  
Immune Responses ◽  
Human Immune System ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Human Immune

Characterization of main cytokine sources from the innate and adaptive immune responses following primary 17DD yellow fever vaccination in adults

Vaccine ◽  
2011 ◽  
Vol 29 (3) ◽  
pp. 583-592 ◽  
Author(s):  
Maria Luiza Silva ◽  
Marina Angela Martins ◽  
Luçandra Ramos Espírito-Santo ◽  
Ana Carolina Campi-Azevedo ◽  
Denise Silveira-Lemos ◽  
...  
Keyword(s):  
Immune Responses ◽  
Yellow Fever ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Yellow Fever Vaccination

scholarly journals Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Young-Su Yi ◽  
Young-Jin Son ◽  
Chongsuk Ryou ◽  
Gi-Ho Sung ◽  
Jong-Hoon Kim ◽  
...  
Keyword(s):  
Immune Responses ◽  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Adaptive Immune Responses ◽  
Functional Roles ◽  
Pathogen Invasion ◽  
Adaptive Immune ◽  
Biological Responses

Inflammation is a series of complex biological responses to protect the host from pathogen invasion. Chronic inflammation is considered a major cause of diseases, such as various types of inflammatory/autoimmune diseases and cancers. Spleen tyrosine kinase (Syk) was initially found to be highly expressed in hematopoietic cells and has been known to play crucial roles in adaptive immune responses. However, recent studies have reported that Syk is also involved in other biological functions, especially in innate immune responses. Although Syk has been extensively studied in adaptive immune responses, numerous studies have recently presented evidence that Syk has critical functions in macrophage-mediated inflammatory responses and is closely related to innate immune response. This review describes the characteristics of Syk-mediated signaling pathways, summarizes the recent findings supporting the crucial roles of Syk in macrophage-mediated inflammatory responses and diseases, and discusses Syk-targeted drug development for the therapy of inflammatory diseases.

scholarly journals Characterization of Innate and Adaptive Immune Responses in PYNOD-Deficient Mice

2018 ◽  
Vol 2 (4) ◽  
pp. 129-141
Author(s):  
Shinsuke Nakajima ◽  
Ryu Imamura ◽  
Miya Yoshino ◽  
Mayumi Sakurai ◽  
Kohsuke Tsuchiya ◽  
...  
Keyword(s):  
Immune Responses ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Deficient Mice

scholarly journals Signaling Through Nucleic Acid Sensors and Their Roles in Inflammatory Diseases

2021 ◽  
Vol 11 ◽  
Author(s):  
Haruna Okude ◽  
Daisuke Ori ◽  
Taro Kawai
Keyword(s):  
Nucleic Acid ◽  
Immune Responses ◽  
Nucleic Acids ◽  
Inflammatory Diseases ◽  
Host Cells ◽  
Type I Interferons ◽  
Type I ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Sensor Molecules

Recognition of pathogen-derived nucleic acids by pattern-recognition receptors (PRRs) is essential for eliciting antiviral immune responses by inducing the production of type I interferons (IFNs) and proinflammatory cytokines. Such responses are a prerequisite for mounting innate and pathogen-specific adaptive immune responses. However, host cells also use nucleic acids as carriers of genetic information, and the aberrant recognition of self-nucleic acids by PRRs is associated with the onset of autoimmune or autoinflammatory diseases. In this review, we describe the mechanisms of nucleic acid sensing by PRRs, including Toll-like receptors, RIG-I-like receptors, and DNA sensor molecules, and their signaling pathways as well as the disorders caused by uncontrolled or unnecessary activation of these PRRs.

scholarly journals Characterization of homologous and heterologous adaptive immune responses in porcine reproductive and respiratory syndrome virus infection

2012 ◽  
Vol 43 (1) ◽  
pp. 30 ◽  
Author(s):  
Ivan Díaz ◽  
Mariona Gimeno ◽  
Laila Darwich ◽  
Nuria Navarro ◽  
Liudmila Kuzemtseva ◽  
...  
Keyword(s):  
Virus Infection ◽  
Immune Responses ◽  
Respiratory Syndrome Virus ◽  
Adaptive Immune Responses ◽  
Adaptive Immune
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