scholarly journals A Comprehensive Analysis of the Current Status and Unmet Needs in Kidney Transplantation in Southeast Asia

2017 ◽  
Vol 4 ◽  
Author(s):  
Chitranon Chan-on ◽  
Minnie M. Sarwal
Author(s):  
Goh Kim Chuan ◽  
Avijit Gupta

Southeast Asia, with most of its area receiving an annual rainfall of more than 2000 mm, is a region of positive water balance. It is also an area where unfulfilled demand for water is not unknown. Such a contradiction happens at times in its towns and cities. Several Malaysian urban settlements, for example, suffer occasionally from water shortage in a country with an average annual rainfall of about 3000 mm. Kuala Lumpur went through a prolonged period of water shortage in 1998 (Hamirdin 1998) in spite of large allocations made earlier in various five-year plans towards developing water supply infrastructure. Such shortages are common during long dry periods associated with El Niño. Regional water shortages may become more common in future, especially with the rising population and economic expansion. The shortages are the result of an inability to meet the rising demand of water in cities driven by both increasing population and progressive prosperity. Serious shortage occurs in large cities such as Jakarta, Bangkok, and Manila where a significant proportion of their population has no immediate access to municipal potable water. Even where piped connection exists, supplies are not available round the clock and often do not meet the required water quality standards. In many cities the local sources are inadequate and water has to be brought in from rural areas. The demand for water in a city has to be met on both quantitative and qualitative terms. For example, drinking water supplied to households by a municipal administration has to meet a given standard (WHO 1993). Ideally a city should have enough water to drink, to meet industrial demand, and to be able to store an adequate volume under pressure for firefighting and street cleansing. Supplying a city with water requires water sources, a treatment system, a distribution system, and arrangements for treating waste water and its disposal. In this chapter we review the current status of water supply in urban Southeast Asia and the sources that are available, concentrating on the major cities. We indicate the success stories as well as the shortcomings.


Pathogens ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 405 ◽  
Author(s):  
Hany M. Elsheikha ◽  
Ruqaiyyah Siddiqui ◽  
Naveed Ahmed Khan

Although major strides have been made in developing and testing various anti-acanthamoebic drugs, recurrent infections, inadequate treatment outcomes, health complications, and side effects associated with the use of currently available drugs necessitate the development of more effective and safe therapeutic regimens. For any new anti-acanthamoebic drugs to be more effective, they must have either superior potency and safety or at least comparable potency and an improved safety profile compared to the existing drugs. The development of the so-called ‘next-generation’ anti-acanthamoebic agents to address this challenge is an active area of research. Here, we review the current status of anti-acanthamoebic drugs and discuss recent progress in identifying novel pharmacological targets and new approaches, such as drug repurposing, development of small interfering RNA (siRNA)-based therapies and testing natural products and their derivatives. Some of the discussed approaches have the potential to change the therapeutic landscape of Acanthamoeba infections.


Author(s):  
Felicia U. Eke ◽  
Taiwo A. Ladapo ◽  
Augustina N. Okpere ◽  
Olalekan Olatise ◽  
Ifeoma Anochie ◽  
...  

2019 ◽  
Vol 34 (8) ◽  
pp. 1254-1261 ◽  
Author(s):  
Raymond Vanholder ◽  
Vianda S Stel ◽  
Kitty J Jager ◽  
Norbert Lameire ◽  
Fiona Loud ◽  
...  

Abstract Kidney transplantation offers better outcomes and quality of life at lower societal costs compared with other options of renal replacement therapy. In this review of the European Kidney Health Alliance, the current status of kidney transplantation throughout Europe and suggestions for improvement of transplantation rates are reported. Although the European Union (EU) has made considerable efforts in the previous decade to stimulate transplantation activity, the discrepancies among European countries suggest that there is still room for improvement. The EU efforts have partially been neutralized by external factors such as economic crises or legal issues, especially the illicit manipulation of waiting lists. Hence, growth in the application of transplantation throughout Europe virtually remained unchanged over the last few years. Continued efforts are warranted to further stimulate transplantation rates, along with the current registration and data analysis efforts supported by the EU in the Effect of Differing Kidney Disease Treatment Modalities and Organ Donation and Transplantation Practices on Health Expenditure and Patient Outcomes project. Future actions should concentrate on organization, harmonization and improvement of the legal consent framework, population education and financial stimuli.


2016 ◽  
Vol 38 ◽  
pp. e2016026 ◽  
Author(s):  
Viroj Wiwanitkit

2017 ◽  
Vol 34 (6) ◽  
pp. 1270-1282 ◽  
Author(s):  
Nikolaos Dervenis ◽  
Athanasia Maria Mikropoulou ◽  
Paris Tranos ◽  
Panagiotis Dervenis

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