scholarly journals The current status of Zika virus in Southeast Asia

2016 ◽  
Vol 38 ◽  
pp. e2016026 ◽  
Author(s):  
Viroj Wiwanitkit
Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 266 ◽  
Author(s):  
Aryamav Pattnaik ◽  
Bikash R. Sahoo ◽  
Asit K. Pattnaik

The recently emerged Zika virus (ZIKV) spread to the Americas, causing a spectrum of congenital diseases including microcephaly in newborn and Guillain-Barré syndrome (GBS) in adults. The unprecedented nature of the epidemic and serious diseases associated with the viral infections prompted the global research community to understand the immunopathogenic mechanisms of the virus and rapidly develop safe and efficacious vaccines. This has led to a number of ZIKV vaccine candidates that have shown significant promise in human clinical trials. These candidates include nucleic acid vaccines, inactivated vaccines, viral-vectored vaccines, and attenuated vaccines. Additionally, a number of vaccine candidates have been shown to protect animals in preclinical studies. However, as the epidemic has waned in the last three years, further development of the most promising vaccine candidates faces challenges in clinical efficacy trials, which is needed before a vaccine is brought to licensure. It is important that a coalition of government funding agencies and private sector companies is established to move forward with a safe and effective vaccine ready for deployment when the next ZIKV epidemic occurs.


Author(s):  
Goh Kim Chuan ◽  
Avijit Gupta

Southeast Asia, with most of its area receiving an annual rainfall of more than 2000 mm, is a region of positive water balance. It is also an area where unfulfilled demand for water is not unknown. Such a contradiction happens at times in its towns and cities. Several Malaysian urban settlements, for example, suffer occasionally from water shortage in a country with an average annual rainfall of about 3000 mm. Kuala Lumpur went through a prolonged period of water shortage in 1998 (Hamirdin 1998) in spite of large allocations made earlier in various five-year plans towards developing water supply infrastructure. Such shortages are common during long dry periods associated with El Niño. Regional water shortages may become more common in future, especially with the rising population and economic expansion. The shortages are the result of an inability to meet the rising demand of water in cities driven by both increasing population and progressive prosperity. Serious shortage occurs in large cities such as Jakarta, Bangkok, and Manila where a significant proportion of their population has no immediate access to municipal potable water. Even where piped connection exists, supplies are not available round the clock and often do not meet the required water quality standards. In many cities the local sources are inadequate and water has to be brought in from rural areas. The demand for water in a city has to be met on both quantitative and qualitative terms. For example, drinking water supplied to households by a municipal administration has to meet a given standard (WHO 1993). Ideally a city should have enough water to drink, to meet industrial demand, and to be able to store an adequate volume under pressure for firefighting and street cleansing. Supplying a city with water requires water sources, a treatment system, a distribution system, and arrangements for treating waste water and its disposal. In this chapter we review the current status of water supply in urban Southeast Asia and the sources that are available, concentrating on the major cities. We indicate the success stories as well as the shortcomings.


2020 ◽  
Vol 8 ◽  
pp. 251513552092388
Author(s):  
Edwin David G. McIntosh

The success in preventing hepatitis B virus and human papillomavirus infections by means of vaccination paves the way for the development of other vaccines to prevent sexually transmitted infections (STIs) such as gonorrhoea, syphilis, chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus. The current status of vaccine development for these infections will be explored in this review. The general principles for success include the need for prevention of latency, persistence and repeat infections. A reduction in transmission of STIs would reduce the global burden of disease. Therapeutic activity of vaccines against STIs would be advantageous over preventative activity alone, and prevention of congenital and neonatal infections would be an added benefit. There would be an added value in the prevention of long-term consequences of STIs. It may be possible to re-purpose ‘old’ vaccines for new indications. One of the major challenges is the determination of the target populations for STI vaccination.


Author(s):  
Maria Fernanda Rios Grassi ◽  
Antônio Carlos Albuquerque Bandeira ◽  
Luana Leandro Gois ◽  
Geraldo Gileno de Sá Oliveira

Since isolation of Zika virus (ZIKV) in Uganda from Zika forest in the 1947, for sixty years the virus has caused only scattered human cases in Africa and Southeast Asia. From 2007, outbreaks with an increasing number of cases, including cases with neurological manifestations, have been occurring in Pacific islands. In 2015, ZIKV reached Brazil with an explosive number of cases and a severe neurological impact on fetuses and newborns. The natural history and several immunological aspects of ZIKV infection need to be characterized. In this review it is summarized the spread of ZIKV around the world and pointed out some gaps on the immunological knowledge related to the infection. The characterization of the immunodominant/protective immune response would contribute to vaccine and diagnosis tests development.


2021 ◽  
Vol 12 ◽  
Author(s):  
Paulene S. Pineda ◽  
Ester B. Flores ◽  
Jesus Rommel V. Herrera ◽  
Wai Yee Low

The swamp buffalo is a domesticated animal commonly found in Southeast Asia. It is a highly valued agricultural animal for smallholders, but the production of this species has unfortunately declined in recent decades due to rising farm mechanization. While swamp buffalo still plays a role in farmland cultivation, this species’ purposes has shifted from draft power to meat, milk, and hide production. The current status of swamp buffaloes in Southeast Asia is still understudied compared to its counterparts such as the riverine buffaloes and cattle. This review discusses the background of swamp buffalo, with an emphasis on recent work on this species in Southeast Asia, and associated genetics and genomics work such as cytogenetic studies, phylogeny, domestication and migration, genetic sequences and resources. Recent challenges to realize the potential of this species in the agriculture industry are also discussed. Limited genetic resource for swamp buffalo has called for more genomics work to be done on this species including decoding its genome. As the economy progresses and farm mechanization increases, research and development for swamp buffaloes are focused on enhancing its productivity through understanding the genetics of agriculturally important traits. The use of genomic markers is a powerful tool to efficiently utilize the potential of this animal for food security and animal conservation. Understanding its genetics and retaining and maximizing its adaptability to harsher environments are a strategic move for food security in poorer nations in Southeast Asia in the face of climate change.


2019 ◽  
Author(s):  
Mohammad Rachmat Sule ◽  
Wawan Gunawan A. Kadir ◽  
Toshifumi Matsuoka ◽  
Harris Prabowo ◽  
Gusti Suarnaya Sidemen

Sign in / Sign up

Export Citation Format

Share Document