The creation of scientific facilities of the “megascience” class is a complex and lengthy process, for the implementation of which the resources of several states are usually attracted.At the same time, there are a number of organizational and legal models that make it possible to use not only the resources of the state, but also attract private investors for the implementation of megascience research projects. In this regard, the article reveals the features of applying the mechanism of public-private partnership in the scientific field, and also offers an analysis of the organizational and legal models for creating scientific projects of the "mega-science" class using public-private partnership, possible taking into account the current legislation of the Russian Federation.