Successful Spontaneous Pregnancy and Live Birth in a Woman With Premature Ovarian Insufficiency and 10 Years of Amenorrhea: A Case Report

Objective The purpose of this study was to compare the pregnancy outcomes among young patients with occult premature ovarian insufficiency (OPOI), advanced-age patients with diminished ovarian reserve (DOR), and advanced-age patients with normal ovarian reserve. Methods We retrospectively reviewed 324 women who underwent their first cycles of in vitro fertilization/intracytoplasmic sperm injection. The women were divided into the following groups: young women with OPOI, advanced-age women with DOR, and advanced-age women with normal ovarian reserve. The outcomes were compared among the different groups: Results The rates of live birth and embryo implantation in the young OPOI group were significantly higher than in the advanced-age DOR group, but comparable to those in the advanced-age normal ovarian reserve group. Moreover, the abortion rate was significantly lower in young OPOI patients compared with advanced-age patients with or without DOR. Conclusion Higher embryo implantation and live birth rates and a lower abortion rate can be achieved in young patients with OPOI compared with older patients. The better outcomes in advanced-age patients with normal ovarian reserve compared with DOR may be related to egg quantity rather than quality.

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Spontaneous pregnancy in a patient with premature ovarian insufficiency after a failed attempt of ovulation induction

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20213488 ◽

2021 ◽

Vol 10 (9) ◽

pp. 3584

Author(s):

Nasuha Yaacob ◽

Fadzlin M. Adzlan ◽

Siti Nabillah Ab Rahman

Keyword(s):

Hormone Replacement Therapy ◽

Menstrual Cycle ◽

Caesarean Section ◽

Ovulation Induction ◽

Hormone Replacement ◽

Premature Ovarian Insufficiency ◽

Ovarian Insufficiency ◽

Healthy Baby ◽

Spontaneous Pregnancy ◽

Failed Attempt

Premature ovarian insufficiency (POI) is defined as intermittent or permanent gonadal insufficiency before age of 40 years. POI causes female infertility hence pregnancies are uncommon but not impossible. Ovarian failure is not permanent, unlike menopause. There could be intermittent ovulation and spontaneous pregnancy. Many protocols aimed to restore ovarian functions have been described in the recent years. This is a case of POI women who conceived spontaneously in the immediate menstrual cycle after a failed attempt at ovarian stimulation following many years on hormone replacement therapy (HRT). She had an unremarkable pregnancy and delivered a healthy baby via caesarean section.

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Triple X and premature ovarian insufficiency - case report

Endocrine Abstracts ◽

10.1530/endoabs.41.gp63 ◽

2016 ◽

Author(s):

Catarina Roque ◽

Catarina Moniz ◽

Carlos Vasconcelos

Keyword(s):

Case Report ◽

Premature Ovarian Insufficiency ◽

Ovarian Insufficiency

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Premature Ovarian Insufficiency After Bone Marrow Transplantation for Thalassemia Major in a Patient With Primary Amenorrhea and 46, XY Karyotype: a Case Report and Literature Review

10.21203/rs.3.rs-154411/v1 ◽

2021 ◽

Author(s):

Hui Li ◽

Jin Li ◽

Xiaohong Li ◽

Hong Yi ◽

Qixiu Ren ◽

...

Keyword(s):

Bone Marrow ◽

Case Report ◽

Bone Marrow Transplant ◽

Marrow Transplant ◽

Premature Ovarian Insufficiency ◽

Sex Characteristics ◽

Primary Amenorrhea ◽

Thalassaemia Major ◽

Ovarian Insufficiency ◽

Detailed Medical History

Abstract Background: Iatrogenic factor is one of the recognized causes for premature ovarian insufficiency. The aim of this case report was to present a rare case with premature ovarian insufficiency and 46, XY karyotype after bone marrow transplant for thalassaemia major at childhood. We also reviewed some relevant literature in this report.Case presentation: A 17-year-old girl was presented with primary amenorrhea and premature ovarian insufficiency after receiving chemotherapy and bone marrow therapy from her brother due to thalassaemia major at childhood. She had poor secondary sex characteristics, assessed as stage I for the development of breasts and external genitalia based on the Tanner scale. Transabdominal ultrasound showed small uterus with visible endometrial lining and small ovaries. Laboratory data showed hypergonadotropic hypogonadism profile with low level of estrogen and high level of follicular-stimulating hormone (FSH). Patient’s peripheral lymphocytes karyotype was 46, XY. Conclusions: A correct diagnosis is not only dependent on clinical manifestations, but also the detailed medical history. In light of the relatively high prevalence of thalassemia, fertility preservation should be considered for young girls before they receive chemotherapy, radiation treatment and bone marrow transplant.

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