scholarly journals MTHFR rs1801133 Polymorphism Is Associated With Liver Fibrosis Progression in Chronic Hepatitis C: A Retrospective Study

2020 ◽  
Vol 7 ◽  
Author(s):  
Daniel Pineda-Tenor ◽  
Ana Zaida Gómez-Moreno ◽  
Juan José Sánchez-Ruano ◽  
Tomas Artaza-Varasa ◽  
Ana Virseda-Berdices ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Retrospective Study ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Fibrosis Progression

Factors accelerating liver fibrosis progression in renal transplant patients receiving ribavirin monotherapy for chronic hepatitis C

2005 ◽  
Vol 76 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Nassim Kamar ◽  
Anne Boulestin ◽  
Janick Selves ◽  
Laure Esposito ◽  
Karine Sandres-Saune ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Renal Transplant ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Fibrosis Progression ◽  
Transplant Patients ◽  
Renal Transplant Patients

Role of polymorphic markers for the genes of hemostasis and platelet receptors in liver fibrosis progression in patients with chronic hepatitis C

2016 ◽  
Vol 88 (8) ◽  
pp. 93-98
Author(s):  
E E Starostina ◽  
L M Samokhodskaya ◽  
T P Rozina ◽  
T N Krasnova ◽  
E B Yarovaya ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Melting Curve ◽  
Integral Model ◽  
Melting Curve Analysis ◽  
Progression Rate ◽  
Platelet Receptors ◽  
Fibrosis Progression

Aim. To estimate the clinical and prognostic value of the carriage of different allele variants of the gene polymorphisms of the coagulation system and platelet receptors in the progression of liver fibrosis (LF) in patient with chronic hepatitis C (CHC). Subjects and methods. The investigation enrolled 177 patients with CHC and liver cirrhosis at its outcome who were divided into 2 groups according to the rate of LF progression: 1) 89 patients with rapid (rapid fibrosis) and 2) 88 patients with slow (slow fibrosis) progression. The polymorphism of the study genes was studied using a real-time polymerase chain reaction and a melting curve analysis. Results. In CHC patients, the FV 1691G/A genotype was more often in the rapid progressors than that in the slow progressors (10.11% vs 1.14%; p=0.011). The A allele of the 1691 G/A FV gene was more common in the rapid fibrosis group than that in the slow fibrosis group (1.7% vs 5.56%, odd ratio 9.787; p=0.139). In our investigation, the polymorphic marker GA in the FII 20210 G/A gene, as well as the 4G allele (5G4G + 4G4G genotypes) and the 4G allele of PAI-I -675 5G/4G were more often seen in the rapid fibrosis group than that in the slow fibrosis group; the detection rate was only at the trend level (p=0.118, p=0.112, and p=0.117 respectively). There were no significant differences between the groups in the spread of variant genotypes and alleles of other study genes. Integral model construction by coding «profibrogenic» genotypes (FV 1691 G/A, FII 20210 G/A, PAI-I -675 5G/4G) showed that the fibrosis progression rate expressed as fibrosis units annually also increased with higher total scores (p=0.039), indicating the combined effect of these genes. Conclusion. The carriage of mutant genotypes of FV 1691 G/A, FII 20210 G/A, and PAI-I -675 5G/4G genes is a prognostic factor for rapid CHC progression.

Sa1065 Higher Rate of Liver Fibrosis Progression in Untreated Chronic Hepatitis C With High Baseline FIB-4 ≥1.45: A Prospective Study

2013 ◽  
Vol 144 (5) ◽  
pp. S-987
Author(s):  
Suparat Khemnark ◽  
Anchalee Avihingsanon ◽  
Pisit Tangkijvanich ◽  
Pinit Kullavanijaya ◽  
Sombat Treeprasertsuk
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Prospective Study ◽  
Chronic Hepatitis C ◽  
High Baseline ◽  
Fibrosis Progression ◽  
A Prospective Study

Natural history of liver fibrosis progression in patients with chronic hepatitis C

The Lancet ◽  
1997 ◽  
Vol 349 (9055) ◽  
pp. 825-832 ◽  
Author(s):  
Thierry Poynard ◽  
Pierre Bedossa ◽  
Pierre Opolon
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Natural History ◽  
Chronic Hepatitis C ◽  
Fibrosis Progression ◽  
History Of

scholarly journals Mathematic Model for Prediction of Liver Fibrosis Progression Rate in Patients with Chronic Hepatitis C Based on Combination of Genomic Markers

2015 ◽  
Vol 70 (6) ◽  
pp. 651-661 ◽  
Author(s):  
Larisa Mikhaylovna Samokhodskaia ◽  
Ekaterina Evgen'evna Starostina ◽  
Elena Borisovna Yarovaya ◽  
Tat'yana Nikolaevna Krasnova ◽  
Nikolay Alekseevich Mukhin ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Gene Polymorphisms ◽  
Mathematic Model ◽  
Genetic Profile ◽  
Progression Rate ◽  
Virus Genotype ◽  
Fibrosis Progression

Aim of study. To evaluate clinical significance of different combinations of gene polymorphisms IL-1b, IL-6, IL-10, TNF, HFE, TGF-b, ATR1, NOS3894, CYBA, AGT, MTHFR, FII, FV, FVII, FXIII, ITGA2, ITGB3, FBG, PAI and their prognostic value for prediction of liver fibrosis progression rate in patients with chronic hepatitis C (CHC).Subjects and methods: 118 patients with CHC were divided into «fast» and «slow» (fibrosis rate progression ≥0,13 and 0,13 fibrosis units/yr; n =64 and n =54) fibrosis groups. Gene polymorphisms were determined. Statistical analysis was performed using Statistica 10.Results. A allele (p =0,012) and genotype AA (p =0,024) of AGT G-6T gene, as well as T allele (p =0,013) and MT+TT genotypes (p =0,005) of AGT 235 M/T gene were significantly more common in «fast fibrosers» than in «slow fibrosers». Patients with genotype TT of CYBA 242 C/T had a higher fibrosis progression rate than patients with CC+CT genotype (p =0,02). Our analysis showed a protective effect of TT genotype of ITGA2 807 C/T on fibrosis progression rate (p =0,03). There was a trend (p 0,15) to higher fibrosis progression rate in patients with mutant alleles and genotypes of TGFb +915 G/C, FXIII 103 G/T, PAI -675 5G/4G genes. Other gene polymorphisms were not associated with enhanced liver fibrosis. To build a mathematical model for prediction of liver fibrosis progression rate we performed coding with scores for genotypes and virus genotype. Total score correlated with the fibrosis progression rate (R =0,39, p =0,000).Conclusion: Determination of genetic profile of the patient and virus genotype allows to predict the course of CHC. 

scholarly journals A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Rasha El Sharkawy ◽  
◽  
Ali Bayoumi ◽  
Mayada Metwally ◽  
Alessandra Mangia ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Fibrosis Progression ◽  
Mica Gene ◽  
Tgf Β1
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