scholarly journals Change of Retinal Vessels in Different Sectors of the Parapapillary Area in Primary Open-Angle Glaucoma

2021 ◽  
Vol 8 ◽  
Author(s):  
Jingyi Cheng ◽  
Hongmei Zhao ◽  
Chunhui Jiang ◽  
Xiangmei Kong ◽  
Xinghuai Sun
Keyword(s):  
Visual Field ◽  
Healthy Subjects ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Visual Field Defects ◽  
Mean Deviation ◽  
Retinal Vessels ◽  
Open Angle ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness

Purpose: To investigate the changes in the retinal vessels (RVs) in different sectors in patients with primary open-angle glaucoma (POAG), and their possible correlations with retinal nerve fiber layer thickness (RNFLT) and visual-field defects in the temporal parapapillary region.Methods: The RV diameters, RNFLTs, and visual-field parameters were measured. The temporal parapapillary region was divided into the temporal (T, 315°-45°), temporal superior (TS, 45°-90°), and temporal inferior sectors (TI, 270°-315°). The changes in the RV diameters in each sector were determined, and their relationships with RNFLT, the mean deviation (MD), and visual field sensitivity (VFS) were examined.Results: Fifty POAG patients (50 eyes) and 50 healthy subjects (50 eyes) were included. Compared with the healthy subjects, the POAG group had a significantly smaller accumulated parapapillary RV diameter (P < 0.001), which was positively correlated with the MD and RNFLT. When the different temporal sectors were examined, the accumulated RV diameters were significantly smaller in the POAG group than in the healthy controls in the TI and T sectors, but not in the TS sector. The accumulated diameters in the TI and T sectors were correlated with the corresponding RNFLTs (all P < 0.05), but only the accumulated diameter in the TI sector was correlated with the VFS.Conclusions: In POAG, the changes in the RVs differed between different temporal sectors, with the most prominent changes occurring in the TI and T sectors.

scholarly journals Early Primary Open-Angle Glaucoma

2018 ◽  
Vol 80 (4) ◽  
pp. 25-31
Author(s):  
Austin R. Lifferth
Keyword(s):  
Visual Field ◽  
Primary Open Angle Glaucoma ◽  
Population Studies ◽  
Open Angle Glaucoma ◽  
Visual Field Defects ◽  
Open Angle ◽  
Fiber Layer ◽  
Advanced Stages ◽  
Early Primary ◽  
Field Defects

Glaucoma is the leading cause of irreversible blindness worldwide and is projected to affect more than 79.6 million people by 2020, over 10% of whom will be bilaterally blind.1 This multifactorial progressive optic neuropathy causes characteristic retinal nerve fiber layer damage that will eventually lead to associated glaucomatous visual field defects if left untreated. Unfortunately, these visual field defects are difficult for the patient to detect until more advanced stages and, as a result, early glaucoma is usually asymptomatic.2 This paper presents a case that is consistent with population studies that suggest that as many as half of people with glaucoma are unaware that they have the disease.3

Visual Field Defects and Normal Nerve Fiber Layer: May They Coexist in Primary Open-Angle Glaucoma?

2000 ◽  
Vol 214 (2) ◽  
pp. 119-121 ◽  
Author(s):  
Renato De Natale ◽  
Michele Marraffa ◽  
Roberta Morbio ◽  
Laura Tomazzoli ◽  
Luciano Bonomi
Keyword(s):  
Visual Field ◽  
Nerve Fiber ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Visual Field Defects ◽  
Open Angle ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Field Defects

scholarly journals Diagnostic capability of different morphological parameters for primary open‐angle glaucoma in the Chinese population

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ruoshi Li ◽  
Xia Wang ◽  
Yahui Wei ◽  
Yuan Fang ◽  
Tian Tian ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Chinese Population ◽  
Primary Open Angle Glaucoma ◽  
Early Stage ◽  
Open Angle Glaucoma ◽  
Structural Parameters ◽  
Open Angle ◽  
Fiber Layer ◽  
Diagnostic Capability ◽  
Diagnostic Power

Abstract Background To assess the diagnostic capability of novel Bruch’s membrane opening (BMO)-based disc parameters, the BMO-minimum rim width (BMO-MRW) and the BMO-minimum rim area (BMO-MRA) in the Chinese population and compare them to the retinal nerve fiber layer (RNFL) from optical coherence tomography (OCT) and the rim area (RA) from the Heidelberg retinal tomograph-III (HRT-III). Methods In total, 200 eyes of 77 healthy and 123 primary open-angle glaucoma (POAG) subjects were included in this cross-sectional study. All participants underwent the visual field test and structural measurements by OCT and HRT-III. The areas under the receiver operating characteristic curves (AUCs) of different structural parameters were calculated to assess their diagnostic power and compared using the DeLong test. Results In populations with different characteristics, the BMO-MRW and BMO-MRA had better diagnostic power than the RA. In discriminating between all POAG subjects and healthy controls and between early-stage patients and controls, the global BMO-MRW had comparable AUCs with the RNFL, but the BMO-MRA had lower AUCs than the RNFL. In healthy subjects with macrodiscs, both the global and sectoral BMO-MRW were thinner than those in healthy subjects with normal disc size. The AUCs of BMO-MRA, BMO-MRW and RNFL in subjects with macrodiscs were comparable. Additionally, in the myopic population, the BMO-MRA and BMO-MRW had comparable AUCs with the RNFL. Conclusions The BMO-MRW had comparable diagnostic power with the RNFL, and compared with BMO-MRW, the BMO-MRA might have advantages in certain populations, such as macrodiscs. All OCT-derived parameters exceeded the RA in diagnostic capability.

Correlation between retinal nerve fiber layer thickness and IOP variation in glaucoma suspects and patients with primary open-angle glaucoma

2020 ◽  
pp. 112067212095758
Author(s):  
Sebastião Cronemberger ◽  
Artur W Veloso ◽  
Christy Veiga ◽  
Gustavo Scarpelli ◽  
Yara C Sasso ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Inferior Quadrant

Purpose: To analyze the relationship between retinal nerve fiber layer thickness (RNFLT) and intraocular pressure (IOP) variation in glaucoma suspects (GS) and patients with primary open-angle glaucoma (POAG). Methods: Thirty-one GS and 34 POAG patients underwent ophthalmologic examination and 24-h IOP measurements. GS had IOPs ranging from 19 to 24 mmHg and/or suspicious appearance of the optic nerve. POAG patients had reproducible abnormal visual fields. We only included patients who presented with short-term IOP fluctuation >6 mm Hg (∆IOP). Only one eye per patient was included through a randomized process. Peripapillary RNFLT was assessed by spectral-domain optical coherence tomography. We correlated RNFLT with IOP parameters. Results: Mean IOP was similar between GS and POAG groups (15.6 ± 3.47 vs 15.6 ± 2.83 mmHg, p = 0.90) as was IOP peak at 6 AM (21.7 ± 3.85 vs 21.3 ± 3.80 mmHg, p = 0.68). Statistically significant negative correlations were found in POAG group between IOP at 6 AM and RNFLT in global ( rs = −0.543; p < 0.001), inferior ( rs = −0.540; p < 0.001), superior ( rs = −0.405; p = 0.009), and nasal quadrants ( rs = −0.561; p < 0.001). Negative correlations were also found between ∆IOP and RNFLT in global ( rs = −0.591; p < 0.001), and all other sectors ( p < 0.05). In GS IOP at 6 AM correlated only with inferior quadrant ( rs = −0.307; p = 0.047). Conclusion: IOP at 6 AM and ∆IOP had negative correlations with RNFLT quadrants in POAG. In GS this correlation occurred between IOP at 6 AM and inferior quadrant. These findings may indicate potential risk factors for glaucoma progression.

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