scholarly journals Genomic and Functional Characterization of qnr-Encoding Plasmids from Municipal Wastewater Biosolid Klebsiella pneumoniae Isolates

2015 ◽  
Vol 6 ◽  
Author(s):  
Ella Kaplan ◽  
Noa Sela ◽  
Adi Doron-Faigenboim ◽  
Shiri Navon-Venezia ◽  
Edouard Jurkevitch ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Municipal Wastewater ◽  
Functional Characterization

Structural and functional characterization of peptidyl-tRNA hydrolase from Klebsiella pneumoniae

2021 ◽  
Vol 1869 (1) ◽  
pp. 140554
Author(s):  
Surbhi Mundra ◽  
Ravi Kant Pal ◽  
Sarita Tripathi ◽  
Anupam Jain ◽  
Ashish Arora
Keyword(s):  
Klebsiella Pneumoniae ◽  
Functional Characterization

scholarly journals Crystal structure and functional characterization of OmpK36, the osmoporin of Klebsiella pneumoniae

Structure ◽  
1999 ◽  
Vol 7 (4) ◽  
pp. 425-434 ◽  
Author(s):  
R Dutzler ◽  
G Rummel ◽  
S Albertí ◽  
S Hernández-Allés ◽  
PS Phale ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Klebsiella Pneumoniae ◽  
Functional Characterization

scholarly journals Genome sequencing and functional characterization of the non-pathogenic Klebsiella pneumoniae KpGe bacteria

2018 ◽  
Vol 20 (5) ◽  
pp. 293-301 ◽  
Author(s):  
Wanessa C. Lima ◽  
Trestan Pillonel ◽  
Claire Bertelli ◽  
Estelle Ifrid ◽  
Gilbert Greub ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Genome Sequencing ◽  
Functional Characterization

scholarly journals Identification and Characterization of a New Porin Gene of Klebsiella pneumoniae: Its Role in β-Lactam Antibiotic Resistance

1999 ◽  
Vol 181 (9) ◽  
pp. 2726-2732 ◽  
Author(s):  
Antonio Doménech-Sánchez ◽  
Santiago Hernández-Allés ◽  
Luis Martínez-Martínez ◽  
Vicente J. Benedí ◽  
Sebastián Albertí
Keyword(s):  
Escherichia Coli ◽  
Klebsiella Pneumoniae ◽  
Blot Analysis ◽  
Southern Blot Analysis ◽  
Functional Characterization ◽  
Standard Laboratory ◽  
Lactam Antibiotic ◽  
Resistant Strains ◽  
Identification And Characterization

ABSTRACT Klebsiella pneumoniae porin genes were analyzed to detect mutations accounting for the porin deficiency observed in many β-lactam-resistant strains. PCR and Southern blot analysis revealed the existence of a third porin gene in addition to the OmpK36 and OmpK35 porin genes previously described. This new porin gene was designated ompK37 and is present in all of the clinical isolates tested. The OmpK37 porin gene was cloned, sequenced, and overexpressed in Escherichia coli. In contrast to that of the major porins, OmpK37 porin expression was only detectable by Western blot analysis in porin-deficient β-lactam-resistant strains, suggesting strong down regulation under standard laboratory conditions. Functional characterization suggested a narrower pore for the OmpK37 porin than for K. pneumoniae porins OmpK36 and OmpK35. This correlated with the susceptibility to certain β-lactam antibiotics, since a K. pneumoniae strain expressing porin OmpK37, but not porin OmpK36 or OmpK35, was less susceptible to β-lactam antibiotics than the same strain expressing either porin OmpK36 or OmpK35.

scholarly journals Functional Characterization of a Novel Outer Membrane Porin KpnO, Regulated by PhoBR Two-Component System in Klebsiella pneumoniae NTUH-K2044

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41505 ◽  
Author(s):  
Vijaya Bharathi Srinivasan ◽  
Manjunath Venkataramaiah ◽  
Amitabha Mondal ◽  
Vasanth Vaidyanathan ◽  
Tanvi Govil ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Outer Membrane ◽  
Functional Characterization ◽  
Two Component System ◽  
Component System ◽  
Outer Membrane Porin ◽  
Two Component

scholarly journals Functional characterization of a novel Mn2+ dependent protein serine/threonine kinase KpnK, produced by Klebsiella pneumoniae strain MGH78578

FEBS Letters ◽  
2012 ◽  
Vol 586 (21) ◽  
pp. 3778-3786 ◽  
Author(s):  
Vijaya Bharathi Srinivasan ◽  
Vasanth Vaidyanathan ◽  
Amitabha Mondal ◽  
Manjunath Venkataramaiah ◽  
Govindan Rajamohan
Keyword(s):  
Klebsiella Pneumoniae ◽  
Functional Characterization ◽  
Serine Threonine Kinase ◽  
Threonine Kinase ◽  
Dependent Protein

Functional characterization of human brown adipose tissue metabolism

2020 ◽  
Vol 477 (7) ◽  
pp. 1261-1286 ◽  
Author(s):  
Marie Anne Richard ◽  
Hannah Pallubinsky ◽  
Denis P. Blondin
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Functional Characterization ◽  
Human Infants ◽  
Positron Emission ◽  
Brown Adipose ◽  
Treatment Of Obesity ◽  
And Function

Brown adipose tissue (BAT) has long been described according to its histological features as a multilocular, lipid-containing tissue, light brown in color, that is also responsive to the cold and found especially in hibernating mammals and human infants. Its presence in both hibernators and human infants, combined with its function as a heat-generating organ, raised many questions about its role in humans. Early characterizations of the tissue in humans focused on its progressive atrophy with age and its apparent importance for cold-exposed workers. However, the use of positron emission tomography (PET) with the glucose tracer [18F]fluorodeoxyglucose ([18F]FDG) made it possible to begin characterizing the possible function of BAT in adult humans, and whether it could play a role in the prevention or treatment of obesity and type 2 diabetes (T2D). This review focuses on the in vivo functional characterization of human BAT, the methodological approaches applied to examine these features and addresses critical gaps that remain in moving the field forward. Specifically, we describe the anatomical and biomolecular features of human BAT, the modalities and applications of non-invasive tools such as PET and magnetic resonance imaging coupled with spectroscopy (MRI/MRS) to study BAT morphology and function in vivo, and finally describe the functional characteristics of human BAT that have only been possible through the development and application of such tools.

Sign in / Sign up

Export Citation Format

Share Document