Pre-stimulus BOLD-network activation modulates EEG spectral activity during working memory retention

Abstract Similar to sleeping after learning, a brief period of wakeful resting after encoding new information supports memory retention in contrast to task-related cognition. Recent evidence suggests that working memory capacity (WMC) is related to sleep-dependent declarative memory consolidation. We tested whether WMC moderates the effect of a brief period of wakeful resting compared to performing a distractor task subsequent to encoding a word list. Participants encoded and immediately recalled a word list followed by either an 8 min wakeful resting period (eyes closed, relaxed) or by performing an adapted version of the d2 test of attention for 8 min. At the end of the experimental session (after 12–24 min) and again, after 7 days, participants were required to complete a surprise free recall test of both word lists. Our results show that interindividual differences in WMC are a central moderating factor for the effect of post-learning activity on memory retention. The difference in word retention between a brief period of wakeful resting versus performing a selective attention task subsequent to encoding increased in higher WMC individuals over a retention interval of 12–24 min, as well as over 7 days. This effect was reversed in lower WMC individuals. Our results extend findings showing that WMC seems not only to moderate sleep-related but also wakeful resting-related memory consolidation.

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Applying brain network activation tool on working memory ERPs in a scopolamine model of Alzheimer's disease

Neuroscience Letters ◽

10.1016/j.neulet.2011.05.198 ◽

2011 ◽

Vol 500 ◽

pp. e44-e45

Author(s):

Revital Shani-Hershkovitch ◽

Amit Reches ◽

Dani Kerem ◽

Noga Pinchuk ◽

Naama Levy-Cooperman ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Working Memory ◽

Brain Network ◽

Network Activation ◽

Model Of Alzheimer’S Disease

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Brain Network Activation (BNA) Reveals Scopolamine-Induced Impairment of Visual Working Memory

Journal of Molecular Neuroscience ◽

10.1007/s12031-014-0250-6 ◽

2014 ◽

Vol 54 (1) ◽

pp. 59-70 ◽

Cited By ~ 10

Author(s):

Amit Reches ◽

Naama Levy-Cooperman ◽

Ilan Laufer ◽

Revital Shani-Hershkovitch ◽

Keren Ziv ◽

...

Keyword(s):

Working Memory ◽

Visual Working Memory ◽

Brain Network ◽

Network Activation

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Comparison of internal recitation and working memory retention cued by the same poetic phrase

NeuroImage ◽

10.1016/s1053-8119(00)91267-9 ◽

2000 ◽

Vol 11 (5) ◽

pp. S335

Author(s):

Kayako Matsuo ◽

Chikako Kato ◽

Masako Matsuzawa ◽

Tomohisa Okada ◽

Tetsuo Moriya ◽

...

Keyword(s):

Working Memory ◽

Memory Retention

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Cognitive Performance, Aerobic Fitness, Motor Proficiency, and Brain Function Among Children Newly Diagnosed With Craniopharyngioma

Journal of the International Neuropsychological Society ◽

10.1017/s1355617718001170 ◽

2019 ◽

Vol 25 (04) ◽

pp. 413-425 ◽

Cited By ~ 1

Author(s):

Heather M. Conklin ◽

Kirsten K. Ness ◽

Jason M. Ashford ◽

Matthew A. Scoggins ◽

Robert J. Ogg ◽

...

Keyword(s):

Working Memory ◽

Executive Functions ◽

Aerobic Fitness ◽

Memory Task ◽

Peak Oxygen Uptake ◽

Neural Activation ◽

Proton Radiation ◽

Cognitive Changes ◽

Motor Proficiency ◽

Network Activation

AbstractObjectives: Craniopharyngioma survivors experience cognitive deficits that negatively impact quality of life. Aerobic fitness is associated with cognitive benefits in typically developing children and physical exercise promotes recovery following brain injury. Accordingly, we investigated cognitive and neural correlates of aerobic fitness in a sample of craniopharyngioma patients. Methods: Patients treated for craniopharyngioma [N=104, 10.0±4.6 years, 48% male] participated in fitness, cognitive and fMRI (n=51) assessments following surgery but before proton radiation therapy. Results: Patients demonstrated impaired aerobic fitness [peak oxygen uptake (PKVO2)=23.9±7.1, 41% impaired (i.e., 1.5 SD<normative mean)], motor proficiency [Bruininks-Oseretsky (BOT2)=38.6±9.0, 28% impaired], and executive functions (e.g., WISC-IV Working Memory Index (WMI)=96.0±15.3, 11% impaired). PKVO2 correlated with better executive functions (e.g., WISC-IV WMI r=.27, p=.02) and academic performance (WJ-III Calculation r=.24, p=.04). BOT2 correlated with better attention (e.g., CPT-II omissions r=.26, p=.04) and executive functions (e.g., WISC-IV WMI r=.32, p=.01). Areas of robust neural activation during an n-back task included superior parietal lobule, dorsolateral prefrontal cortex, and middle and superior frontal gyri (p<.05, corrected). Higher network activation was associated with better working memory task performance and better BOT2 (p<.001). Conclusions: Before adjuvant therapy, children with craniopharyngioma demonstrate significantly reduced aerobic fitness, motor proficiency, and working memory. Better aerobic fitness and motor proficiency are associated with better attention and executive functions, as well as greater activation of a well-established working memory network. These findings may help explain differential risk/resiliency with respect to acute cognitive changes that may portend cognitive late effects. (JINS, 2019, 25, 413–425)

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