scholarly journals Correlation Between Plasma CircRNA-089763 and Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Non-cardiac Surgery

2020 ◽  
Vol 14 ◽  
Author(s):  
Hongli Zhou ◽  
Fuyu Li ◽  
Wanlin Ye ◽  
Maozhou Wang ◽  
Xian Zhou ◽  
...  
BMJ Open ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. e034657 ◽  
Author(s):  
Qianyu Cui ◽  
Dexiang Wang ◽  
Min Zeng ◽  
Jia Dong ◽  
Hailong Jin ◽  
...  

IntroductionThe incidence of covert stroke and cognitive dysfunction has gradually increased due to an ageing population. Recently, a prospective cohort study reported perioperative covert stroke was associated with an increased risk of postoperative cognitive dysfunction (POCD) 1 year after non-cardiac surgery. However, the mechanism remains unclear.Methods and analysisThis is a prospective observational trial aiming to investigate the cumulative incidence of perioperative covert stroke and test the hypothesis that perioperative covert stroke associates with POCD in elderly patients undergoing non-cardiac and non-neurological surgery. Data on risk factors, brain MRI, cognitive function evaluation and serum immune-inflammatory cytokines will be collected and analysed.Ethics and disseminationEthical approval has been granted by the Medical Ethics Committee of Beijing Tiantan Hospital, Capital Medical University (reference number: KY2017-027-02). The results of this study will be disseminated through presentations at scientific conferences and publication in scientific journals.Trial registration numberNCT03081429.


2021 ◽  
Author(s):  
Courtney M. Hrdlicka ◽  
Jeffrey Wang ◽  
Magdy Selim

AbstractNeurological complications after cardiac surgery and percutaneous cardiac interventions are not uncommon. These include periprocedural stroke, postoperative cognitive dysfunction after cardiac surgery, contrast-induced encephalopathy after percutaneous interventions, and seizures. In this article, we review the incidence, pathophysiology, diagnosis, and management of these complications. Improved understanding of these complications could lead to their prevention, faster detection, and facilitation of diagnostic workup and appropriate treatment.


Stroke ◽  
2003 ◽  
Vol 34 (2) ◽  
pp. 508-513 ◽  
Author(s):  
Joseph P. Mathew ◽  
Hilary P. Grocott ◽  
Barbara Phillips-Bute ◽  
Mark Stafford-Smith ◽  
Daniel T. Laskowitz ◽  
...  

2006 ◽  
Vol 23 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Leo A. Bokeriia ◽  
Elena Z. Golukhova ◽  
Nataliya Y. Breskina ◽  
Anna G. Polunina ◽  
Dmitry M. Davydov ◽  
...  

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