scholarly journals Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats

2021 ◽  
Vol 15 ◽  
Author(s):  
Farshid Etaee ◽  
Arezoo Rezvani-Kamran ◽  
Somayeh Komaki ◽  
Masoumeh Asadbegi ◽  
Nafiseh Faraji ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Open Field ◽  
Spatial Learning ◽  
Avoidance Learning ◽  
Field Tests ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Memory And Learning ◽  
Male Wistar Rats ◽  
The Impact

Little is known about the effects of methamphetamine (Meth) and buprenorphine (Bup) on memory and learning in rats. The aim of this investigation was to examine the impact of Meth and Bup on memory and learning. Fourteen male Wistar rats weighing 250–300 g were assigned to four groups: Sham, Meth, Bup, and Meth + Bup and were treated for 1 week. Spatial learning and memory, avoidance learning, and locomotion were assessed using the Morris water maze, passive avoidance learning, and open field tests, respectively. Meth and Bup impaired spatial learning and memory in rats. Co-administration of Meth + Bup did not increase the time spent in the target quadrant compared to Meth alone in the MWM. The Bup and Meh + Bup groups were found with an increase in step-through latency (STLr) and a decrease in the time spent in the dark compartment (TDC). Meth and Bup had no effects on locomotor activity in the open field test. Bup showed a beneficial effect on aversive memory. Since Bup demonstrates fewer side effects than other opioid drugs, it may be preferable for the treatment of avoidance memory deficits in patients with Meth addiction.

scholarly journals Co-administration of Rauwolfia vomitoria with Gongronema latifolium or Vernonia amygdalina on spatial learning, memory, and some bio-molecules

2015 ◽  
Vol 7 (1) ◽  
pp. 82-87 ◽  
Author(s):  
Moses B Ekong ◽  
Aniekan I Peter ◽  
Ubong U Ekpene
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Psychotic Disorders ◽  
Acute Effect ◽  
Tween 20 ◽  
Spatial Learning And Memory ◽  
Vernonia Amygdalina ◽  
Male Wistar Rats ◽  
Gongronema Latifolium ◽  
Rauwolfia Vomitoria

Background: Rauwolfia vomitoria is a plant with sedative properties found useful in the management of psychotic disorders, with adverse effects being reported on its use in different brain areas.Aims and Objectives: To investigate the acute effect of combination of Rauwolfia vomitoria with either Gongronema latifolium or Vernonia amygdalina on spatial learning and memory, and some bio-molecules in rats.Materials and Methods: 24 adult male Wistar rats weighing between 220 g - 300 g were equally divided into four groups (1-4). Group 1 animals were the control treated with 0.5 ml of Tween 20. Groups 2, 3 and 4 animals were administered respectively; 150 mg/kg of R. vomitoria, a combination of 150 mg/kg of R. vomitoria and 200 mg/kg of G. latifolium, and a combination of 150 mg/kg of R. vomitoria and 200 mg/kg of V. amygdalina for seven days. On days 4-7 concurrent with treatment, spatial learning and memory test was carried out using the Morris water maze, and the animals were sacrificed twelve hours after the last treatment. Their sera were used for enzyme and other bio-molecules analysis.Results: There was no difference in spatial learning and memory. The activities of aspartate aminotrans­ferase, alanine aminotrans­ferase and alkaline phos­phatase, and the serum cholesterol and triglycerides levels were also not different compared to the control group.Conclusion: The dose and duration of administration of the extract of R. vomitoria either alone, or in combination with G. latifolium or V. amygdalina may not affect spatial learning or memory, or alter serum biomolecules.Asian Journal of Medical Sciences Vol.7(1) 2015 82-87

scholarly journals Effects of testosterone on spatial learning and memory in adult male rats

2011 ◽  
Vol 59 (4) ◽  
pp. 484-496 ◽  
Author(s):  
Mark D. Spritzer ◽  
Emily D. Daviau ◽  
Meagan K. Coneeny ◽  
Shannon M. Engelman ◽  
W. Tyler Prince ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Adult Male ◽  
Male Rats ◽  
Spatial Learning And Memory

scholarly journals Genistein improves spatial learning and memory in male rats with elevated glucose level during memory consolidation

2015 ◽  
Vol 140 ◽  
pp. 15-22 ◽  
Author(s):  
Yumi Kohara ◽  
Shinichiro Kawaguchi ◽  
Rika Kuwahara ◽  
Yutaro Uchida ◽  
Yushi Oku ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Glucose Level ◽  
Spatial Learning ◽  
Memory Consolidation ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Elevated Glucose

scholarly journals Naloxone Ameliorates Spatial Memory Deficits and Hyperthermia Induced by a Neurotoxic Methamphetamine Regimen in Male Rats

2019 ◽  
Vol 8 ◽  
pp. 1182 ◽  
Author(s):  
Solmaz Khalifeh ◽  
Mehdi Khodamoradi ◽  
Vahid Hajali ◽  
Hamed Ghazvini ◽  
Lelia Eliasy ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Spatial Memory ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Impairment ◽  
Memory Performance ◽  
Poor Performance ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Opiate Antagonist

Background: Methamphetamine (METH) as a synthetic psychostimulant is being increasingly recognized as a worldwide problem, which may induce memory impairment. On the other hand, it is well established that naloxone, an opiate antagonist, has some beneficial effects on learning and memory. The present research aimed at evaluating naloxone effects on spatial learning and memory impairment triggered by a neurotoxic regimen of METH in male rats. Materials and Methods: The animals received the subcutaneous (sc) regimen of METH (4×6 mg/kg at 2-h intervals), intraperitoneal (ip) naloxone (4×1 mg/kg at 2-h intervals), or normal saline at four events. The Nal-METH group of rats received four naloxone injections (1 mg/kg, ip) 30 min before each METH injection (6 mg/kg, sc) at 2-h intervals. Seven days later, they were evaluated for spatial learning and memory in the Morris Water Maze (MWM) task. Result: METH regimen induced hyperthermia, as well as a poor performance, in the acquisition and retention phases of the task, indicating spatial learning and memory impairment compared to the controls. Naloxone administration (1 mg/kg, ip) before each METH injection led to significant attenuations of both hyperthermia and METH adverse effects on the rat performance in the MWM task. Conclusion: The results revealed that pretreatment with the opiate antagonist naloxone could prevent METH adverse effects on body temperature and memory performance. It seems that the opioidergic system and hyperthermia may, at least partially, be involved in METH effects on spatial memory. [GMJ. 2019;8:e1182]

scholarly journals Protective effect of fennel, and its major component trans-anethole against social isolation induced behavioral deficits in rats

2020 ◽  
Vol 107 (1) ◽  
pp. 30-39 ◽  
Author(s):  
S. Raman ◽  
M. Asle-Rousta ◽  
M. Rahnema
Keyword(s):  
Learning And Memory ◽  
Social Isolation ◽  
Spatial Learning ◽  
Male Rats ◽  
Anxiety And Depression ◽  
Control Group ◽  
Spatial Learning And Memory ◽  
Foeniculum Vulgare ◽  
Behavioral Deficits ◽  
Swimming Test

AbstractSocial isolation damages the nervous system by weakening the antioxidant system and leading to behavioral disorders. Fennel (Foeniculum vulgare Mill.) is an herbal plant that has antioxidant and neuroprotective properties. The objective of this study was to evaluate the effect of fennel methanol extract and its major component trans-anethole on spatial learning and memory, anxiety and depression in male rats exposed to social isolation stress.Rats were divided into six groups of Control (C), Fennel (F), trans-Anethole (A), Isolation, Isolation-F and Isolation-A. The rats were kept in the cage alone for 30 days to induce isolation. Fennel extract (150 mg/kg) and trans-anethole (80 mg/kg) were also gavaged during this period. At the end of the course, spatial learning and memory, anxiety and depression were measured by Morris water maze (MWM), elevated plus maze (EPM) and forced swimming test (FST), respectively.Learning and memory were impaired in isolated rats. Swimming time and distance to reach the hidden platform in these animals increased compared with controls (P < 0.05). In the EPM test, the percentage of open arm entries and open arm time also decreased significantly in the Isolation group (P < 0.01). The immobilization time in FST also increased significantly in these animals compared with the Control group (P < 0.001). Fennel and trans-anethole were both able to eliminate these changes in isolated rats.It is concluded that fennel and its major component, trans-anethole are suitable candidates for the prevention and treatment of stress-induced neurological disorders.

scholarly journals The effect of intra-nucleus accumbens shell injection of ascorbic acid on spatial learning and memory in adult male rats

2015 ◽  
Vol 2 (1) ◽  
pp. 73-81
Author(s):  
Fateme Shahsavari ◽  
Mahdi Abbasnejhad ◽  
Reihane Naderi ◽  
Saeed Esmaeeli Mahani ◽  
◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Nucleus Accumbens ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Adult Male ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Nucleus Accumbens Shell
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