scholarly journals The effect of intra-nucleus accumbens shell injection of ascorbic acid on spatial learning and memory in adult male rats

2015 ◽  
Vol 2 (1) ◽  
pp. 73-81
Author(s):  
Fateme Shahsavari ◽  
Mahdi Abbasnejhad ◽  
Reihane Naderi ◽  
Saeed Esmaeeli Mahani ◽  
◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Nucleus Accumbens ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Adult Male ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Nucleus Accumbens Shell

scholarly journals Effects of testosterone on spatial learning and memory in adult male rats

2011 ◽  
Vol 59 (4) ◽  
pp. 484-496 ◽  
Author(s):  
Mark D. Spritzer ◽  
Emily D. Daviau ◽  
Meagan K. Coneeny ◽  
Shannon M. Engelman ◽  
W. Tyler Prince ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Adult Male ◽  
Male Rats ◽  
Spatial Learning And Memory

scholarly journals Genistein improves spatial learning and memory in male rats with elevated glucose level during memory consolidation

2015 ◽  
Vol 140 ◽  
pp. 15-22 ◽  
Author(s):  
Yumi Kohara ◽  
Shinichiro Kawaguchi ◽  
Rika Kuwahara ◽  
Yutaro Uchida ◽  
Yushi Oku ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Glucose Level ◽  
Spatial Learning ◽  
Memory Consolidation ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Elevated Glucose

scholarly journals Naloxone Ameliorates Spatial Memory Deficits and Hyperthermia Induced by a Neurotoxic Methamphetamine Regimen in Male Rats

2019 ◽  
Vol 8 ◽  
pp. 1182 ◽  
Author(s):  
Solmaz Khalifeh ◽  
Mehdi Khodamoradi ◽  
Vahid Hajali ◽  
Hamed Ghazvini ◽  
Lelia Eliasy ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Spatial Memory ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Impairment ◽  
Memory Performance ◽  
Poor Performance ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Opiate Antagonist

Background: Methamphetamine (METH) as a synthetic psychostimulant is being increasingly recognized as a worldwide problem, which may induce memory impairment. On the other hand, it is well established that naloxone, an opiate antagonist, has some beneficial effects on learning and memory. The present research aimed at evaluating naloxone effects on spatial learning and memory impairment triggered by a neurotoxic regimen of METH in male rats. Materials and Methods: The animals received the subcutaneous (sc) regimen of METH (4×6 mg/kg at 2-h intervals), intraperitoneal (ip) naloxone (4×1 mg/kg at 2-h intervals), or normal saline at four events. The Nal-METH group of rats received four naloxone injections (1 mg/kg, ip) 30 min before each METH injection (6 mg/kg, sc) at 2-h intervals. Seven days later, they were evaluated for spatial learning and memory in the Morris Water Maze (MWM) task. Result: METH regimen induced hyperthermia, as well as a poor performance, in the acquisition and retention phases of the task, indicating spatial learning and memory impairment compared to the controls. Naloxone administration (1 mg/kg, ip) before each METH injection led to significant attenuations of both hyperthermia and METH adverse effects on the rat performance in the MWM task. Conclusion: The results revealed that pretreatment with the opiate antagonist naloxone could prevent METH adverse effects on body temperature and memory performance. It seems that the opioidergic system and hyperthermia may, at least partially, be involved in METH effects on spatial memory. [GMJ. 2019;8:e1182]

scholarly journals Protective effect of fennel, and its major component trans-anethole against social isolation induced behavioral deficits in rats

2020 ◽  
Vol 107 (1) ◽  
pp. 30-39 ◽  
Author(s):  
S. Raman ◽  
M. Asle-Rousta ◽  
M. Rahnema
Keyword(s):  
Learning And Memory ◽  
Social Isolation ◽  
Spatial Learning ◽  
Male Rats ◽  
Anxiety And Depression ◽  
Control Group ◽  
Spatial Learning And Memory ◽  
Foeniculum Vulgare ◽  
Behavioral Deficits ◽  
Swimming Test

AbstractSocial isolation damages the nervous system by weakening the antioxidant system and leading to behavioral disorders. Fennel (Foeniculum vulgare Mill.) is an herbal plant that has antioxidant and neuroprotective properties. The objective of this study was to evaluate the effect of fennel methanol extract and its major component trans-anethole on spatial learning and memory, anxiety and depression in male rats exposed to social isolation stress.Rats were divided into six groups of Control (C), Fennel (F), trans-Anethole (A), Isolation, Isolation-F and Isolation-A. The rats were kept in the cage alone for 30 days to induce isolation. Fennel extract (150 mg/kg) and trans-anethole (80 mg/kg) were also gavaged during this period. At the end of the course, spatial learning and memory, anxiety and depression were measured by Morris water maze (MWM), elevated plus maze (EPM) and forced swimming test (FST), respectively.Learning and memory were impaired in isolated rats. Swimming time and distance to reach the hidden platform in these animals increased compared with controls (P < 0.05). In the EPM test, the percentage of open arm entries and open arm time also decreased significantly in the Isolation group (P < 0.01). The immobilization time in FST also increased significantly in these animals compared with the Control group (P < 0.001). Fennel and trans-anethole were both able to eliminate these changes in isolated rats.It is concluded that fennel and its major component, trans-anethole are suitable candidates for the prevention and treatment of stress-induced neurological disorders.

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