scholarly journals Microstructural Changes in Patients With Parkinson's Disease Comorbid With REM Sleep Behaviour Disorder and Depressive Symptoms

2018 ◽  
Vol 9 ◽  
Author(s):  
Farzaneh Ghazi Sherbaf ◽  
Yasna Rostam Abadi ◽  
Mahtab Mojtahed Zadeh ◽  
Amir Ashraf-Ganjouei ◽  
Hossein Sanjari Moghaddam ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Depressive Symptoms ◽  
Rem Sleep ◽  
Behaviour Disorder ◽  
Microstructural Changes ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder

scholarly journals Parkinson’s Disease with and without REM Sleep Behaviour Disorder: Are There Any Clinical Differences?

2009 ◽  
Vol 61 (3) ◽  
pp. 164-170 ◽  
Author(s):  
Asako Yoritaka ◽  
Hideki Ohizumi ◽  
Shigeki Tanaka ◽  
Nobutaka Hattori
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rem Sleep ◽  
Behaviour Disorder ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder

scholarly journals Evolution of prodromal Parkinson’s disease and dementia with Lewy bodies: a prospective study

Brain ◽  
2019 ◽  
Vol 142 (7) ◽  
pp. 2051-2067 ◽  
Author(s):  
Seyed-Mohammad Fereshtehnejad ◽  
Chun Yao ◽  
Amelie Pelletier ◽  
Jacques Y Montplaisir ◽  
Jean-François Gagnon ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rem Sleep ◽  
Colour Vision ◽  
Rating Scale ◽  
Lewy Bodies ◽  
Behaviour Disorder ◽  
Mixed Effect ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder

Abstract Parkinson’s disease has a long prodromal stage with various subclinical motor and non-motor manifestations; however, their evolution in the years before Parkinson’s disease is diagnosed is unclear. We traced the evolution of early motor and non-motor manifestations of synucleinopathy from the stage of idiopathic rapid eye movement (REM) sleep behaviour disorder until defined neurodegenerative disease. During 2004–16, we recruited and then annually followed 154 polysomnography-proven patients with idiopathic REM sleep behaviour disorder, of whom 55 phenoconverted to defined parkinsonism or dementia. Longitudinal data on multiple prodromal features, including the Unified Parkinson’s Disease Rating Scale parts I–III, quantitative motor tests, olfaction, colour vision, cognition, and autonomic functions were gathered annually (average = five follow-up visits, range: 2–12 years). The same measures were also assessed in 102 age- and sex-matched healthy control subjects. By looking backward from the time of dementia or parkinsonism diagnosis, we examined trajectories of each prodromal feature using mixed effect models. Based on analysis, olfactory loss was first to develop, with predicted onset >20 years before phenoconversion. This was followed by impaired colour vision, constipation, and erectile dysfunction, starting 10–16 years prior to phenoconversion. At 7–9 years before phenoconversion, slight urinary dysfunction and subtle cognitive decline could be detected. Among motor symptoms altered handwriting, turning in bed, walking, salivation, speech, and facial expression began to be disrupted starting 7–11 years prior to parkinsonism diagnosis, but remained mild until soon before phenoconversion. Motor examination abnormalities began 5–7 years before phenoconversion, with the alternate tap test having the longest interval (8 years before phenoconversion). Among cardinal motor phenotypes, bradykinesia appeared first, ∼5–6 years prior to phenoconversion, followed by rigidity (Year −3) and tremor (Year −2). With direct prospective evaluation of an idiopathic REM sleep behaviour disorder cohort during phenoconversion, we documented an evolution of prodromal manifestations similar to that predicted by pathological staging models, with predicted prodromal intervals as long as 20 years.

Probable REM sleep behaviour disorder and STN-DBS outcome in Parkinson's Disease

2010 ◽  
Vol 16 (4) ◽  
pp. 265-269 ◽  
Author(s):  
M. Zibetti ◽  
L. Rizzi ◽  
L. Colloca ◽  
A. Cinquepalmi ◽  
S. Angrisano ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rem Sleep ◽  
Behaviour Disorder ◽  
Sleep Behaviour ◽  
Rem Sleep Behaviour Disorder ◽  
Stn Dbs
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