scholarly journals Serum Metabolites Differentiate Amnestic Mild Cognitive Impairment From Healthy Controls and Predict Early Alzheimer's Disease via Untargeted Lipidomics Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Lumi Zhang ◽  
Lingxiao Li ◽  
Fanxia Meng ◽  
Jie Yu ◽  
Fangping He ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cholesteryl Ester ◽  
Serum Lipid ◽  
Amnestic Mild Cognitive Impairment ◽  
Healthy Controls ◽  
Ganglioside Gm3 ◽  
Serum Metabolites ◽  
Neuromedin B ◽  
Lipid Metabolites

Background and Aim: Alzheimer's disease (AD) is the most common type of dementia and presents with metabolic perturbations early in the disease process. In order to explore biomarkers useful in predicting early AD, we compared serum metabolites among patients suffering different stages of AD.Methods: We recruited 107 participants including 23 healthy controls (HC), 21 amnestic mild cognitive impairment (aMCI), 24 non-amnestic mild cognitive impairment (naMCI) and 39 AD patients. Via liquid chromatography-mass spectrometry based serum untargeted lipidomics analysis, we compared differences in serum lipid metabolites among these patient groups and further elucidated biomarkers that differentiate aMCI from HC.Results: There were significant differences of serum lipid metabolites among the groups, and 20 metabolites were obtained under negative ion mode from HC and aMCI comparison. Notably, 16:3 cholesteryl ester, ganglioside GM3 (d18:1/9z-18:1) and neuromedin B were associated with cognition and increased the predictive effect of aMCI to 0.98 as revealed by random forest classifier. The prediction model composed of MoCA score, 16:3 cholesteryl ester and ganglioside GM3 (d18:1/9z-18:1) had good predictive performance for aMCI. Glycerophospholipid metabolism was a pathway common among HC/aMCI and aMCI/AD groups.Conclusion: This study provides preliminary evidence highlighting that 16:3 cholesteryl ester were useful for AD disease monitoring while ganglioside GM3 (d18:1/9z-18:1) and neuromedin B discriminated aMCI from HC, which can probably be applied in clinic for early predicting of AD.

[P2-447]: A COMPARISON OF AFFECTIVE THEORY OF MIND ABILITIES BETWEEN PARTICIPANTS WITH AMNESTIC MILD COGNITIVE IMPAIRMENT AND HEALTHY CONTROLS

2017 ◽  
Vol 13 (7S_Part_16) ◽  
pp. P808-P809
Author(s):  
Elif Yildirim ◽  
Ezgi Soncu Buyukiscan ◽  
Asli Demirtas Tatlidede ◽  
Başar Bilgiç ◽  
Hasmet Hanagasi ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Theory Of Mind ◽  
Amnestic Mild Cognitive Impairment ◽  
Healthy Controls

Reaction time intra-individual variability reveals inhibitory deficits in single- and multiple-domain amnestic mild cognitive impairment

2021 ◽  
Author(s):  
Ricky Chow ◽  
Rahel Rabi ◽  
Shahier Paracha ◽  
Brandon P Vasquez ◽  
Lynn Hasher ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Response Inhibition ◽  
Individual Variability ◽  
Amnestic Mild Cognitive Impairment ◽  
Healthy Controls ◽  
Interference Control ◽  
Inhibitory Deficits ◽  
Report Data ◽  
Multiple Domain

Abstract Objectives Amnestic mild cognitive impairment (aMCI), a prodromal stage of Alzheimer’s disease and other dementias, is characterized by episodic memory impairment. Recent evidence has shown inhibitory control deficits in aMCI, but the extent of these deficits across inhibitory domains (i.e., response inhibition and interference control) and aMCI subtypes (i.e., single- versus multiple-domain) remains unclear. Few studies have included response time intra-individual variability (RT IIV) in these efforts. The aim of this study was to compare response inhibition and interference control between aMCI subtypes using measures of accuracy, mean RT, and RT IIV. Method We report data from 34 individuals with single-domain aMCI (sdaMCI, 66–86 years), 20 individuals with multiple-domain aMCI (mdaMCI, 68–88 years), and 52 healthy controls (64–88 years) who completed tasks of response inhibition (Go-NoGo) and interference control (Flanker). Group differences in accuracy, mean RT, and RT IIV were examined for both tasks. Results Individuals with mdaMCI had higher RT IIV than the other groups on both tasks. In RT IIV, we observed an interference control deficit in mdaMCI and sdaMCI relative to healthy controls, a finding not observed through accuracy or mean RT. Discussion RT IIV may detect subtle differences in inhibition deficits between aMCI subtypes that may not be evident with conventional behavioral measures. Findings support the supplementary use of RT IIV when assessing early executive function deficits.

scholarly journals Errors on the MoCA's animal-naming: findings from Parkinson's disease patients

2017 ◽  
Vol 29 (7) ◽  
pp. 1227-1228
Author(s):  
Yassar Alamri ◽  
Tim Anderson ◽  
John Dalrymple-Alford ◽  
Michael Macaskill
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Assessment ◽  
Amnestic Mild Cognitive Impairment ◽  
Original Version ◽  
Montreal Cognitive Assessment ◽  
Healthy Controls

We read the findings by Cecato et al. (2016) with great interest. In their study, naming the rhinoceros discriminated between patients with amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) but not healthy controls (HC). Of note, HC participants were significantly younger than aMCI and AD patients. All participants were administered the original version of the Montreal Cognitive Assessment (MoCA) instrument.

scholarly journals P4-613: SEMANTIC INTRUSION ERRORS DIFFERENTIATE AMYLOID POSITIVE AMNESTIC MILD COGNITIVE IMPAIRMENT FROM COGNITIVELY HEALTHY CONTROLS

2019 ◽  
Vol 15 ◽  
pp. P1560-P1560
Author(s):  
Jessica Garcia ◽  
Gabriella Amy Grau ◽  
Giselle Leal ◽  
Marcela Kitaigorodsky ◽  
Rosie E. Curiel ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
Healthy Controls ◽  
Intrusion Errors

Association of the LRP1 gene and cognitive performance with amnestic mild cognitive impairment in elderly Chinese

2009 ◽  
Vol 21 (6) ◽  
pp. 1072-1080 ◽  
Author(s):  
Yong M. Shi ◽  
Hong Zhou ◽  
Zhi J. Zhang ◽  
Hui Yu ◽  
Feng Bai ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Episodic Memory ◽  
Cognitive Performance ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Poor Performance ◽  
Amnestic Mild Cognitive Impairment ◽  
Healthy Controls

ABSTRACTBackground: The genetic region coding for low-density lipoprotein receptor-related protein1 (LRP1) is considered an intriguing susceptibility locus for Alzheimer's disease (AD). Amnestic mild cognitive impairment (aMCI) is characterized by episodic memory impairment and represents the prodromal stage of AD. Our aim in this study is to investigate the relationship between LRP1 genetic variation and aMCI, and the influence of LRP1 on cognitive performance.Methods: We performed a case-control association study analyzing five polymorphisms in LRP1 gene by TaqMan Assays-on-Demand SNP Genotyping. All samples were derived from Chinese subjects (109 cases, 104 healthy controls) and assessed using multi-dimension neuropsychological instruments.Results: We identified haplotypes within the region containing the LRP1 gene. Of these, haplotype TAA (T: rs1800194; A: rs11837145; A: rs10876967) was significantly associated with aMCI, being over-represented in aMCI versus healthy controls. Haplotype TAA was associated with poor performance on episodic memory in all subjects.Conclusions: This study confirms the association between genetic variants in LRP1 and aMCI. Moreover, we have identified a relationship between LRP1 genetic variation and specific aspects of neurocognitive function. Our convergent results suggest that LRP1 plays an important role in cognitive function and possibly in the pathogenesis of aMCI.

scholarly journals The FNAME yields equivalent results differentiating amnestic mild cognitive impairment from subjective cognitive decline and healthy controls in Mexico and the Netherlands

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Juan Francisco Flores‐Vazquez ◽  
Iris Van der Kolk ◽  
José Juan Contreras‐López ◽  
Cecilia Cruz‐Contreras ◽  
Rutger A. Stegeman ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
The Netherlands ◽  
Cognitive Decline ◽  
Amnestic Mild Cognitive Impairment ◽  
Subjective Cognitive Decline ◽  
Healthy Controls
Sign in / Sign up

Export Citation Format

Share Document