scholarly journals Associations of Monocytes and the Monocyte/High-Density Lipoprotein Ratio With Extracranial and Intracranial Atherosclerotic Stenosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhu Liu ◽  
Qingli Fan ◽  
Shizheng Wu ◽  
Yancheng Lei
Keyword(s):  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diagnostic Value ◽  
High Density ◽  
Artery Stenosis ◽  
Severe Stenosis ◽  
Intracranial Atherosclerotic Stenosis ◽  
Potential Marker ◽  
Atherosclerotic Stenosis ◽  
Stenosis Rate

Background: Although the monocyte/high-density lipoprotein ratio (MHR) has been shown to be a potential marker of inflammatory of cardiovascular and cerebrovascular diseases, there are few studies on its relationships with the degree of intracranial and extracranial atherosclerotic stenosis and the stenosis distribution.Methods: In total, 271 patients were admitted for digital subtraction angiography (DSA) examination and were classified into a non-stenosis group and a stenosis group. (1) The two groups were compared and the arteries were categorized according to the degree of intracranial or extracranial atherosclerotic stenosis (if ≥two branches were stenotic, the artery with the most severe stenosis was used). (2) Clinical baseline data and laboratory indexes of patients grouped according to stenosis location (intracranial vs. extracranial) were collected.Results: (1) MHR × 102 [odds ratio (OR) = 1.119, p < 0.001], age (OR = 1.057, p = 0.007), and lymphocyte count (OR = 0.273, p = 0.002) significantly affected the presence of cerebral atherosclerotic stenosis, with an MHR area of 0.82 under the receiver operating characteristic (ROC) curve (AUC) and an optimal diagnostic value of 0.486. Analyses of the moderate, mild, and severe stenosis groups showed that MHR × 102 (OR = 1.07, p < 0.001) significantly affected the severity of stenosis in patients. (2) In the analysis of stenosis at different sites, the rate of extracranial artery stenosis in patients who smoked (OR = 3.86, p = 0.023) and had a reduced lymphocyte level (OR = 0.202, p = 0.001) was remarkably greater than that in patients who smoked (OR = 3.86, p = 0.023). With increasing age, the rate of extracranial artery stenosis raised sharply. With the increase in the MHR level, the stenosis rate of each group was highly greater than that of the non-stenosis group.Conclusion: The MHR has a predictive value for the diagnosis of extracranial and intracranial atherosclerotic stenosis and is correlated with the degree and distribution of stenosis.Trial Registration: Clinical Medical Research Center Project of Qinghai Province (2017-SF-L1). Qinghai Provincial Health Commission Project (Grant #2020-wjzdx-29).

scholarly journals Association of Monocytes and the Monocyte/high-density Lipoprotein Ratio With Intracranial and Extracranial Atherosclerotic Stenosis

2020 ◽  
Author(s):  
Zhu Liu ◽  
Qingli Fan ◽  
Shizheng Wu ◽  
Yancheng Lei ◽  
Wenfang Yang
Keyword(s):  
High Density Lipoprotein ◽  
Inflammatory Marker ◽  
Density Lipoprotein ◽  
Diagnostic Value ◽  
Cerebrovascular Diseases ◽  
High Density ◽  
Artery Stenosis ◽  
Severe Stenosis ◽  
Atherosclerotic Stenosis ◽  
Stenosis Rate

Abstract Background and aims: Although the monocyte/high-density lipoprotein ratio (MHR) has been shown to be a potential inflammatory marker of cardiovascular and cerebrovascular diseases, there are few studies on the relationship between intracranial and extracranial atherosclerotic stenosis degree and its distribution.Methods: A total of 271 patients were admitted for digital subtraction angiography (DSA) examination. (1) The non-stenosis group and the stenosis group were compared, and the artery was grouped according to the degree of intracranial and extracranial atherosclerotic stenosis (if ≥2 branches were stenotic, the artery with the most severe stenosis was used). (2) According to the locations of the intracranial and extracranial artery stenosis groups.clinical baseline data and laboratory indexes of each group of patients were collected.Results: (1) MHR (odds ratio (OR)=1.119, P<0.001), age (OR=1.057, P=0.007), and lymphocyte (OR=0.273, P=0.002) could significantly affect cerebral atherosclerotic stenosis, the AUC (area under the ROC curve) of MHR was 0.82, and the optimal diagnostic value was 0.486. Further analysis of the mild, moderate, and severe stenosis groups showed that MHR (OR=1.07, P<0.001) significantly affected the severity of stenosis in patients. (2) According to the analysis of stenosis at different sites, the rate of extracranial artery stenosis in patients who smoked (OR=3.86, P=0.023) and had a reduced lymphocyte level (OR=0.202, P=0.001) was significantly higher than that in patients who smoked (OR=3.86, P=0.023). With increasing age, the rate of extracranial and extracranial artery stenosis increased significantly. With the increase in MHR level, the stenosis rate of each group was significantly higher than that of the non-stenosis group.Conclusion: MHR has predictive value for the diagnosis of intracranial and extracranial atherosclerotic stenosis and is correlated with the degree and distribution of stenosis.

scholarly journals Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

2020 ◽  
Author(s):  
Wen-Song Yang ◽  
Rui Li ◽  
Yi-Qing Shen ◽  
Xing-Chen Wang ◽  
Qing-Jun Liu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Apo B ◽  
Lipid Ratios ◽  
Intracranial Atherosclerotic Stenosis ◽  
Atherosclerotic Stenosis

Abstract Background: This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population.Methods: This cross-sectional study included 658 consecutive patients with ischemic stroke. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated.Results: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I ratios (all P <0.05) were significantly associated with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Receiver operating characteristic (ROC) curves analyses revealed that the apo B/apo A-I ratio had the largest area under the ROC curve (AUC) among lipid levels alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for lipid levels alone for the identification of ICAS.Conclusion: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C, and apo B/apo A-I ratios were significantly related to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be a better discriminator for identifying ICAS risk in stroke patients.

scholarly journals Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

2020 ◽  
Author(s):  
Wen-Song Yang ◽  
Rui Li ◽  
Yi-Qing Shen ◽  
Xing-Chen Wang ◽  
Qing-Jun Liu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Lipid Level ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Apo B ◽  
Lipid Ratios ◽  
Intracranial Atherosclerotic Stenosis ◽  
Atherosclerotic Stenosis

Abstract Background: We wished to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population. Methods: We included 658 consecutive patients with ischemic stroke in our cross-sectional study. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated. Results : Ratios of TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I were associated significantly with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Analyses of receiver operating characteristic (ROC) curves revealed the apo B/apo A-I ratio have the highest area under the ROC curve (AUC) value for a lipid level alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for a lipid level alone for identifying ICAS. Conclusion : The ratios of TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C and apo B/apo A-I were related significantly to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be better discriminator for identifying ICAS risk.

scholarly journals Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

2020 ◽  
Author(s):  
Wen-Song Yang ◽  
Rui Li ◽  
Yi-Qing Shen ◽  
Xing-Chen Wang ◽  
Qing-Jun Liu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Stroke Patients ◽  
Apo B ◽  
Lipid Ratios ◽  
Atherosclerotic Stenosis

Abstract Background: This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population.Methods: This cross-sectional study included 658 consecutive patients with ischemic stroke. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated.Results: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I ratios (all P <0.05) were significantly associated with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Receiver operating characteristic (ROC) curves analyses revealed that the apo B/apo A-I ratio had the largest area under the ROC curve (AUC) among lipid levels alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for lipid levels alone for the identification of ICAS.Conclusion: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C, and apo B/apo A-I ratios were significantly related to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be a better discriminator for identifying ICAS risk in stroke patients. Take home message: Several lipid ratios were significantly related to ICAS risk and have several differences between men and women in stroke patients.

scholarly journals Evaluation of monocyte-to-high-density lipoprotein cholesterol ratio and monocyte-to-lymphocyte ratio in ischemic stroke

2020 ◽  
Vol 48 (7) ◽  
pp. 030006052093380
Author(s):  
Huiling Liu ◽  
Feng Zhan ◽  
Yazhou Wang
Keyword(s):  
Ischemic Stroke ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Diagnostic Value ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Stroke Patients ◽  
Cholesterol Ratio ◽  
Lymphocyte Ratio

Objectives We aimed to evaluate the diagnostic value of the combination of the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) with the monocyte-to-lymphocyte ratio (MLR) in ischemic stroke patients. Methods There were 253 patients who were diagnosed with ischemic stroke and 211 healthy subjects enrolled into this retrospective study. Result MHR and MLR were significantly higher in ischemic stroke patients compared with controls. MHR and MLR remained as independent variables for the presence of ischemic stroke. In receiver operating characteristic analyses, the optimal cut-off values for MHR and MLR were 0.28 and 0.19, respectively. The area under the curve for MHR was 0.777 (sensitivity, 66.01%; specificity, 77.25%), and that for MLR was 0.742 (sensitivity, 70.36%; specificity, 67.77%) in ischemic stroke patients. Moreover, the combination MHR and MLR increased the sensitivity compared with MHR or MLR alone. Conclusion The present study shows that a high MHR and MLR are each predictive for the risk of ischemic stroke, and together, they exhibit a better diagnostic value compared with each ratio alone.

scholarly journals Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

2020 ◽  
Author(s):  
Wen-Song Yang ◽  
Rui Li ◽  
Yi-Qing Shen ◽  
Xing-Chen Wang ◽  
Qing-Jun Liu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Stroke Patients ◽  
Apo B ◽  
Lipid Ratios ◽  
Atherosclerotic Stenosis

Abstract Background: This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population.Methods: This cross-sectional study included 658 consecutive patients with ischemic stroke. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated.Results: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I ratios were significantly associated with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Receiver operating characteristic (ROC) curves analyses revealed that the apo B/apo A-I ratio had the largest area under the ROC curve (AUC) among lipid levels alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for lipid levels alone for identification of ICAS.Conclusion: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C, and apo B/apo A-I ratios were significantly related to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be a better discriminator for identifying ICAS risk in stroke patients. Take home message: Variables that were significantly related to ICAS risk included the TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C, and apo B/apo A-I ratios. Among the variables tested, the apo B/apo A-I ratio showed the best performance in identifying ICAS risk in stroke patients. Besides, several gender differences were observed with regard to other lipid ratios.

Sign in / Sign up

Export Citation Format

Share Document