scholarly journals Effects of Synergism of Mindfulness Practice Associated With Transcranial Direct-Current Stimulation in Chronic Migraine: Pilot, Randomized, Controlled, Double-Blind Clinical Trial

2021 ◽  
Vol 15 ◽  
Author(s):  
Luana Dias Santiago Pimenta ◽  
Elidianne Layanne Medeiros de Araújo ◽  
Joyce Poláine dos Santos Silva ◽  
Jamyson Júnior França ◽  
Pedro Nascimento Araújo Brito ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Chronic Migraine ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Mindfulness Practice ◽  
Treatment Result ◽  
Double Blind ◽  
Direct Current Stimulation ◽  
Randomized Controlled ◽  
Double Blind Clinical Trial

Chronic migraine is a difficult disease to diagnose, and its pathophysiology remains undefined. Its symptoms affect the quality of life and daily living tasks of the affected person, leading to momentary disability. This is a pilot, randomized, controlled, double-blind clinical trial study with female patients between 18 and 65 years old with chronic migraine. The patients underwent twelve mindfulness sessions paired with anodal transcranial direct-current stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC), with current intensity of 2 mA applied for 20 min, three times a week for 4 weeks. In addition, 20 min of mindfulness home practices were performed by guided meditation audio files. A total of 30 participants were evaluated after the treatment, and these were subdivided into two groups—active tDCS and sham tDCS, both set to mindfulness practice. The FFMQ-BR (Five Facet of Mindfulness Questionnaire), MIDAS (Migraine Disability Assessment), and HIT-6 (Headache Impact Test) questionnaires were used to evaluate the outcomes. After the treatment, the active mindfulness and tDCS group showed better results in all outcomes. The sham group also showed improvements, but with smaller effect sizes compared to the active group. The only significant difference in the intergroup analysis was the outcome evaluated by HIT-6 in the post treatment result. Our results provide the first therapeutic evidence of mindfulness practices associated with left DLPFC anodal tDCS with a consequent increase in the level of full attention and analgesic benefits in the clinical symptoms of patients with chronic migraine.

scholarly journals Effects of transcranial direct current stimulation on the rehabilitation of painful shoulder following a stroke: protocol for a randomized, controlled, double-blind, clinical trial

Trials ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Janaina Andressa de Souza ◽  
João Carlos Ferrari Corrêa ◽  
Letizzia Dall’ Agnol ◽  
Filipe Ribeiro dos Santos ◽  
Márcia Rafaella Pereira Gomes ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Double Blind ◽  
Painful Shoulder ◽  
Direct Current Stimulation ◽  
Randomized Controlled ◽  
Double Blind Clinical Trial

scholarly journals Effects of transcranial direct current stimulation on patients with post stroke fatigue: A study protocol for a double-blind randomized controlled trial

2021 ◽  
Author(s):  
Weiming Sun ◽  
Xing Sun ◽  
Xiangli Dong ◽  
Guohua Yu ◽  
Lang Shuai ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Controlled Trial ◽  
Double Blind ◽  
Direct Current Stimulation ◽  
Post Stroke ◽  
Randomized Controlled

Abstract Introduction Post stroke fatigue (PSF) is an abnormal, persistent, and unexplained physical and psychological tiredness in patients after stroke. It is a common symptom of stroke patients with poor quality of life and bleak prognosis, and the incidence rate is up to 39–72%. It has been widely reported that medicine treatments achieved a lot of progress, there still needs to develop more powerful new strategies to more powerful effect. The transcranial direct-current stimulation (tDCS) shows great potential for the treatment of PSF. This study proposes to apply a double-blind randomized controlled clinical trial to explore the effect and safety of tDCS combined with routine rehabilitation for PSF. Methods and analysis One hundred patients with PSF will be randomly divided into two groups. One of the groups will receive conventional rehabilitation therapy and active tDCS, whereas another group will receive conventional rehabilitation treatment and sham tDCS. Both groups will receive the intervention for 4 weeks, during which time they will undergo either active or sham tDCS 20 minutes a day, 6 days a week. Primary outcome: Fatigue Severity Scale (FSS) will be measured at baseline every weekend during the intervention period. Secondary results: Fatigue Impact Scale (FIS), Functional Assessment Chronic Illness Therapy (Fatigue) (FACIT-F), Specialized Quality of Life Scale in Stroke (SS-QOL) will be measured at baseline and at the end of the intervention time of 4 weeks. Throughout the study, adverse events and adverse reactions will be measured during every treatment. The research study”Effects of transcranial direct current stimulation on patients with post stroke fatigue” has been approved by the Ethics Committee of the First Affiliated Hospital of Nanchang University: Clinical Medicine Ethics Review [2015]043 in Nov, 2015. Discussion This study will provide insight on the efficacy of transcranial direct-current stimulation for post stroke fatigue. This is a double-blind randomized controlled trial whose aim is to assess the effects of tDCS on PSF.This study can provide more information about the treatment of PSF. This study has a period of follow-up, which allows for greater accuracy. It is a single-center trial and this may be a limitation. The other limitation of this study is a relatively small number of participants; thus, the influence of chance on experimental results cannot be completely ruled out. Trial registration number Chinese Clinical Trial Registry,ChiCTR2000031120. Registered on March 22, 2020. This protocol version number is V1.1.

scholarly journals Effects of transcranial direct current stimulation on patients with disorders of consciousness after traumatic brain injury: study protocol for a randomized, double-blind controlled trial

Trials ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Shilin Li ◽  
Xiangli Dong ◽  
Weiming Sun ◽  
Na Zhao ◽  
Guohua Yu ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Controlled Trial ◽  
Disorders Of Consciousness ◽  
Double Blind ◽  
Direct Current Stimulation ◽  
Randomized Controlled

Abstract Background Disorders of consciousness (DOC) after traumatic brain injury (TBI) raise the mortality of patients, restrict the rehabilitation of patients with TBI, and increase the physical and economic burden that TBI imposes on patients and their families. Thus, treatment to promote early awakening in DOC after TBI is of vital importance. Various treatments have been reported, but there is no advanced evidence base to support them. Transcranial direct current stimulation (tDCS) has shown great potential in promoting neuroelectrochemical effects. This protocol is for a double-blind, randomized, controlled, clinical trial aiming to research the effects and safety of conventional rehabilitation combined with tDCS therapy in patients with DOC after TBI. Methods/design Eighty patients with DOC after TBI will be randomized into one of two groups receiving conventional rehabilitation combined with sham tDCS or conventional rehabilitation combined with active tDCS. The intervention period in each of the two groups will last 4 weeks (20 min per day, 6 days per week). Primary outcomes (Glasgow Outcome Scale (GOS)) will be measured at baseline and the end of every week from the first to the fourth week. Secondary outcomes will be measured at baseline and the end of the fourth week. Adverse events and untoward effects will be measured during each treatment. Discussion Patients with central nervous system lesions have received tDCS as a painless, non-invasive, easily applied and effective therapy for several decades, and there has been some evidence in recent years showing partial improvement on the level of consciousness of partial patients with DOC. However, reports mainly focus on the patients in a minimally conscious state (MCS), and there is a lack of large-sample clinical trials. This protocol presents an objective design for a randomized controlled trial that aims to study the effectiveness of conventional rehabilitation combined with tDCS therapy for DOC after TBI, to evaluate its safety, and to explore effective and economical therapeutic methods. Trial registration Chinese Clinical Trial Registry, ChiCTR1800014808. Registered on 7 February 2018.

scholarly journals Transcranial direct current stimulation in the treatment of pain in women with fibromyalgia: Randomized double-blind clinical trial

2021 ◽  
Author(s):  
Eduardo Henrique Loreti ◽  
Viviane Cristina Tomaz Correa ◽  
Elaine Kakuta ◽  
Renan Gama de Oliveira ◽  
Elisabete Castelon Konkiewitz
Keyword(s):  
Clinical Trial ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Primary Motor Cortex ◽  
Double Blind ◽  
Direct Current Stimulation ◽  
Double Blind Clinical Trial ◽  
Structural Networks ◽  
The Right ◽  
Orbital Region

Background: Among the diseases that encompass chronic pain is fibromyalgia (FM), a syndrome characterized by changes in the functional, chemical and structural networks of the brain. Objectives: To analyze the effects of anodic Transcranial Direct Current Stimulation (tDCS) on the Primary Motor Cortex (M1) for 26 minutes for 10 sessions in the treatment of pain in patients with FM. Design and setting: Randomized double-blind clinical trial to be carried out at the Municipal Physiotherapy Clinic of Fátima do Sul - MS, Brazil. Methods: This is a Research protocol that is in progress. Forty women aged between 18 and 60 years with a medical diagnosis of FM will be selected. Participants will be randomly assigned to two groups (active tDCS and tDCS sham). There will be 10 consecutive sessions. The anode will be positioned at M1 and the cathode in the right sub-orbital region. The intensity will be 2mA applied for 13 minutes, a break of 20 minutes followed by another 13 minutes of stimulation. In the tDCS sham group, the device stays on for 30 seconds and turns off automatically. Participants will be evaluated at the beginning, after 10 sessions and after 30 and 90 days with the visual analogue scale, inventory of attitudes towards pain (primary outcome). Results: this will be the first clinical trial to use this prochotole. Potential limitations include patient compliance. Conclusions: we hope to demonstrate the effects of tDCS on FM and direct further studies.

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