Changes in the Resting-State Cortical Oscillatory Activity 6 Months After Modified Tinnitus Retraining Therapy

AbstractSchizophrenia is among the most debilitating neuropsychiatric disorders. However, clear neurophysiological markers that would identify at-risk individuals represent still an unknown. The aim of this study was to investigate possible alterations in the resting alpha oscillatory activity in normal population high on schizotypy trait, a physiological condition known to be severely altered in patients with schizophrenia. Direct comparison of resting-state EEG oscillatory activity between Low and High Schizotypy Group (LSG and HSG) has revealed a clear right hemisphere alteration in alpha activity of the HSG. Specifically, HSG shows a significant slowing down of right hemisphere posterior alpha frequency and an altered distribution of its amplitude, with a tendency towards a reduction in the right hemisphere in comparison to LSG. Furthermore, altered and reduced connectivity in the right fronto-parietal network within the alpha range was found in the HSG. Crucially, a trained pattern classifier based on these indices of alpha activity was able to successfully differentiate HSG from LSG on tested participants further confirming the specific importance of right hemispheric alpha activity and intrahemispheric functional connectivity. By combining alpha activity and connectivity measures with a machine learning predictive model optimized in a nested stratified cross-validation loop, current research offers a promising clinical tool able to identify individuals at-risk of developing psychosis (i.e., high schizotypy individuals).

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Publisher Correction: Resting state alpha oscillatory activity is a valid and reliable marker of schizotypy

Scientific Reports ◽

10.1038/s41598-021-92571-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Jelena Trajkovic ◽

Francesco Di Gregorio ◽

Francesca Ferri ◽

Chiara Marzi ◽

Stefano Diciotti ◽

...

Keyword(s):

Resting State ◽

Oscillatory Activity ◽

Reliable Marker

AbstractAn amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Efficacy of tinnitus retraining therapy in the treatment of tinnitus: A meta-analysis and systematic review

American Journal of Otolaryngology ◽

10.1016/j.amjoto.2021.103151 ◽

2021 ◽

pp. 103151

Author(s):

Mingkun Han ◽

Yang Xue ◽

Jing Lv

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Tinnitus Retraining Therapy ◽

Retraining Therapy

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Comparison of Tinnitus Masking and Tinnitus Retraining Therapy

Journal of the American Academy of Audiology ◽

10.1055/s-0040-1716016 ◽

2002 ◽

Vol 13 (10) ◽

pp. 559-581 ◽

Cited By ~ 13

Author(s):

James A. Henry ◽

Martin A. Schechter ◽

Stephen M. Nagler ◽

Stephen A. Fausti

Keyword(s):

Clinical Application ◽

Basic Component ◽

Tinnitus Retraining Therapy ◽

Basic Approach ◽

Sound Therapy ◽

The World ◽

Considerable Confusion ◽

International Attention ◽

Retraining Therapy ◽

Tinnitus Masking

Two methods for treating tinnitus are compared. Tinnitus masking has been used for over 25 years, and although this method is used in clinics around the world, there are many misconceptions regarding the proper protocol for its clinical application. Tinnitus retraining therapy has been used clinically for over 12 years and has received considerable international attention. Although these methods are distinctive in their basic approach to tinnitus management, certain aspects of treatment appear similar. These aspects of treatment have created considerable confusion and controversy, especially regarding the use of "sound therapy" as a basic component of treatment. It is the objective of this article to clarify the major differences that exist between these two forms of treatment.

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Three Years Later: Report on the State of Well-Being of Patients with Chronic Tinnitus Who Underwent Modified Tinnitus Retraining Therapy

Audiology and Neurotology ◽

10.1159/000363728 ◽

2014 ◽

Vol 20 (1) ◽

pp. 26-38 ◽

Cited By ~ 18

Author(s):

Claudia Seydel ◽

Heidemarie Haupt ◽

Agnieszka J. Szczepek ◽

Anne Hartmann ◽

Matthias Rose ◽

...

Keyword(s):

Management Strategies ◽

Well Being ◽

The State ◽

Chronic Tinnitus ◽

Tinnitus Retraining Therapy ◽

Psychometric Instruments ◽

Important Health ◽

Retraining Therapy ◽

Treatment Onset ◽

A Minor

Successful management of patients with chronic tinnitus is an important health issue. One of the tinnitus management strategies used at our Tinnitus Center is a combination of tinnitus retraining therapy (TRT) with physiotherapy and psychological management [called modified TRT (MTRT)]. We have used this type of management for over a decade and have described the protocol in detail elsewhere. In the present study, we wanted to determine the effect of MTRT on the well-being of tinnitus patients 3 years after treatment onset. One hundred and thirty patients with chronic tinnitus were assessed using psychometric instruments immediately before 7-day MTRT, immediately after the therapy and 3 years later. Patients with very severe tinnitus-related distress associated with major depression and a risk of suicide were excluded from this study. MTRT resulted in a sustained reduction of tinnitus-related distress. Moreover, the quality of life of patients had increased, as assessed by a separate questionnaire. The effect of MTRT was influenced by the degree of tinnitus-related distress and by the patients' age, the latter being gender dependent. Hearing loss and tinnitus duration had only a minor influence on the therapeutic effect. Taken together, we report a positive change in the state of well-being of patients with chronic tinnitus measurable with various psychometric instruments 3 years after the onset of MTRT. i 2014 S. Karger AG, Basel

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Assessment of Patients for Treatment with Tinnitus Retraining Therapy

Journal of the American Academy of Audiology ◽

10.1055/s-0040-1716014 ◽

2002 ◽

Vol 13 (10) ◽

pp. 523-544 ◽

Cited By ~ 12

Author(s):

James A. Henry ◽

Margaret M. Jastreboff ◽

Pawel J. Jastreboff ◽

Martin A. Schechter ◽

Stephen A. Fausti

Keyword(s):

Clinical Data ◽

Clinical Management ◽

Tinnitus Retraining Therapy ◽

Initial Interview ◽

Retraining Therapy ◽

Methods Of Treatment ◽

Severe Tinnitus

Clinical management for patients complaining of severe tinnitus has improved dramatically in the last 25 years. During that period of time, various methods of treatment have been introduced and are being used with varying degrees of success. One method that has received considerable attention is tinnitus retraining therapy (TRT). This method is being practiced by hundreds of clinicians worldwide, and retrospective clinical data indicate that TRT has been effective for the majority of patients. This article provides a guide for clinicians to evaluate their patients for treatment with TRT. Included in this guide is the expanded version of the TRT initial interview and specific instructions for the clinician administering the interview.

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A consideration of the effect of ear canal resonance and hearing loss upon white noise generators for tinnitus retraining therapy

The Journal of Laryngology & Otology ◽

10.1017/s0022215100138708 ◽

1997 ◽

Vol 111 (9) ◽

pp. 810-813 ◽

Cited By ~ 4

Author(s):

David M. Baguley ◽

Graham J. Beynon ◽

Frances Thornton

Keyword(s):

Hearing Loss ◽

White Noise ◽

Noise Generator ◽

Major Advance ◽

Ear Canal ◽

Tinnitus Retraining Therapy ◽

Hearing Sensitivity ◽

Actual Spectrum ◽

Retraining Therapy ◽

White Noise Generator

AbstractTinnitus retraining therapy has been heralded as a major advance in the alleviation of tinnitus perception. A cornerstone of this technique is to use white noise produced by a white noise generator (WNG) over a period of several months in order to assist the patient to habituate to their tinnitus. There are three factors which influence the frequency spectrum of the perceived noise such that the perception of white noise from a WNG is unlikely. These factors are the actual spectrum of the emitted noise, the ear canal resonance of the patient and the hearing sensitivity of the patient.Advocates of tinnitus retraining therapy state that white noise is the optimal stimulation to assist habituation of tinnitus. This paper demonstrates that this optimal situation is unlikely to be achieved and that this may account for the long periods needed for patients to achieve benefit from the technique. The development of devices that allow for the above factors to be countered is suggested.

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