scholarly journals Unilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex

2021 ◽  
Vol 15 ◽  
Author(s):  
Jing Liu ◽  
Xinyi Huang ◽  
Jiping Zhang
Keyword(s):  
Hearing Loss ◽  
Auditory Cortex ◽  
Conductive Hearing Loss ◽  
Spatial Perception ◽  
Primary Auditory Cortex ◽  
Binaural Hearing ◽  
Adult Rats ◽  
Binaural Processing ◽  
Binaural Interaction ◽  
Conductive Hearing

Binaural hearing is critically important for the perception of sound spatial locations. The primary auditory cortex (AI) has been demonstrated to be necessary for sound localization. However, after hearing onset, how the processing of binaural cues by AI neurons develops, and how the binaural processing of AI neurons is affected by reversible unilateral conductive hearing loss (RUCHL), are not fully elucidated. Here, we determined the binaural processing of AI neurons in four groups of rats: postnatal day (P) 14–18 rats, P19–30 rats, P57–70 adult rats, and RUCHL rats (P57–70) with RUCHL during P14–30. We recorded the responses of AI neurons to both monaural and binaural stimuli with variations in interaural level differences (ILDs) and average binaural levels. We found that the monaural response types, the binaural interaction types, and the distributions of the best ILDs of AI neurons in P14–18 rats are already adult-like. However, after hearing onset, there exist developmental refinements in the binaural processing of AI neurons, which are exhibited by the increase in the degree of binaural interaction, and the increase in the sensitivity and selectivity to ILDs. RUCHL during early hearing development affects monaural response types, decreases the degree of binaural interactions, and decreases both the selectivity and sensitivity to ILDs of AI neurons in adulthood. These new evidences help us to understand the refinements and plasticity in the binaural processing of AI neurons during hearing development, and might enhance our understanding in the neuronal mechanism of developmental changes in auditory spatial perception.

Consequences of Early Conductive Hearing Loss on Long-Term Binaural Processing

2017 ◽  
Vol 38 (5) ◽  
pp. 621-627 ◽  
Author(s):  
Kelley Graydon ◽  
Gary Rance ◽  
Richard Dowell ◽  
Bram Van Dun
Keyword(s):  
Hearing Loss ◽  
Conductive Hearing Loss ◽  
Binaural Processing ◽  
Conductive Hearing

scholarly journals Audiological Performance of ADHEAR Systems in Simulated Conductive Hearing Loss: A Case Series with a Review of the Existing Literature

2021 ◽  
Vol 11 (4) ◽  
pp. 537-546
Author(s):  
Enrico Muzzi ◽  
Valeria Gambacorta ◽  
Ruggero Lapenna ◽  
Giulia Pizzamiglio ◽  
Sara Ghiselli ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Conductive Hearing Loss ◽  
Bone Conduction ◽  
Free Field ◽  
Hearing Threshold ◽  
Case Series ◽  
Binaural Hearing ◽  
Bone Conduction Implant ◽  
Conductive Hearing ◽  
Loudness Summation

A new non-invasive adhesive bone conduction hearing device (ABCD) has been proposed as an alternative solution for reversible bilateral conductive hearing loss in recurrent or long-lasting forms of otitis media with effusion (OME) in children that cannot undergo surgical treatment. Our aim was to assess the effectiveness of ABCD in children with OME. Twelve normal-hearing Italian-speaking volunteers, in whom a conductive hearing loss was simulated, participated in the study. The free-field average hearing threshold was determined and, to evaluate binaural hearing skills, loudness summation and the squelch effect were assessed. Five conditions were tested: (1) unaided without earplugs, (2) unaided with bilateral earplugs, (3) aided right ear with bilateral earplugs, (4) aided left ear with bilateral earplugs, and (5) bilateral aid with bilateral earplugs. Post-hoc analysis showed a significant statistical difference between plugged, unplugged, and each aided condition. The main results were a better loudness summation and a substantial improvement of the squelch effect in the bilaterally aided. Our results suggest that ABCD is a valid treatment for patients with conductive hearing loss that cannot undergo bone conduction implant surgery. It is also important to consider bilateral aids in order to deal with situations in which binaural hearing is fundamental.

Binaural processing after corrected congenital unilateral conductive hearing loss

1994 ◽  
Vol 74 (1-2) ◽  
pp. 99-114 ◽  
Author(s):  
Debra Wilmington ◽  
Lincoln Gray ◽  
Robert Jahrsdoerfer
Keyword(s):  
Hearing Loss ◽  
Conductive Hearing Loss ◽  
Binaural Processing ◽  
Conductive Hearing

Effect of Conductive Hearing Loss and Middle Ear Surgery on Binaural Hearing

1986 ◽  
Vol 95 (5) ◽  
pp. 525-530 ◽  
Author(s):  
Joseph W. Hall ◽  
Eugene L. Derlacki
Keyword(s):  
Hearing Loss ◽  
Middle Ear ◽  
Auditory Processing ◽  
Conductive Hearing Loss ◽  
Binaural Hearing ◽  
Middle Ear Surgery ◽  
Ear Surgery ◽  
Hearing Thresholds ◽  
Masking Level Difference ◽  
Conductive Hearing

This study investigated whether conductive hearing loss reduces normal binaural hearing advantages and whether binaural hearing advantages are normal in patients who have had hearing thresholds improved by middle ear surgery. Binaural hearing was assessed at a test frequency of 500 Hz using the masking level difference and interaural time discrimination thresholds. Results indicated that binaural hearing is often poor in conductive lesion patients and that the reduction in binaural hearing is not always consistent with a simple attenuation of the acoustic signal. Poor binaural hearing sometimes occurs even when middle ear surgery has resulted in bilaterally normal hearing thresholds. Our preliminary results are consistent with the interpretation that auditory deprivation due to conductive hearing loss may result in poor binaural auditory processing.

Conductive Hearing Loss During Infancy

1991 ◽  
Vol 34 (5) ◽  
pp. 1207-1215 ◽  
Author(s):  
Adele D. Gunnarson ◽  
Terese Finitzo
Keyword(s):  
Hearing Loss ◽  
Brain Stem ◽  
Conductive Hearing Loss ◽  
Long Term Effects ◽  
Binaural Interaction ◽  
Auditory Brain Stem ◽  
Significant Difference ◽  
Group B ◽  
Conductive Hearing ◽  
Fluctuating Hearing Loss

Long-term effects on auditory electrophysiology from early fluctuating hearing loss were studied in 27 children, aged 5 to 7 years, who had been evaluated originally in infancy. For controls (Group A), infant auditory brain stem responses (ABRs) were normal from birth to age 2 years. A second group (Group B) had intermittent conductive hearing loss. A third group (Group C) had more abnormal ABRs during infancy than Group B and more severe and frequent conductive hearing loss. For this follow-up study, all children had normal peripheral hearing at test. ABRs were obtained to monaural and binaural stimuli. Binaural interaction (BI) in the ABR was assessed in difference traces, derived by subtracting summed binaural from summed monaural waveforms.Controls differed from both groups with early hearing loss for wave III and wave V latencies and interpeak I–III and I–V latencies. There was a significant difference in the presence of BI. Eight of 9 A subjects and 8 of 9 B subjects, but only 4 of 9 C subjects, had demonstrable BI. Findings suggest that early fluctuating hearing loss disrupts later auditory brain stem electrophysiology.

scholarly journals Hearing loss promotes schizophrenia-relevant brain and behavioral abnormalities in a mouse model of human 22q11.2 Deletion Syndrome

2019 ◽  
Author(s):  
Fhatarah A. Zinnamon ◽  
Freya G. Harrison ◽  
Sandra S. Wenas ◽  
Arne F. Meyer ◽  
Qing Liu ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Mouse Model ◽  
Auditory Cortex ◽  
Conductive Hearing Loss ◽  
Sensorimotor Gating ◽  
22Q11.2 Deletion Syndrome ◽  
Deletion Syndrome ◽  
22Q11.2 Deletion ◽  
Behavioral Abnormalities ◽  
Conductive Hearing

ABSTRACTHearing loss has been implicated as a risk factor for schizophrenia, but it is not known whether this association arises from common etiology, top-down influences (e.g., social isolation), bottom-up neurobiological mechanisms, or combinations of these factors. Patients with 22q11.2 Deletion Syndrome (22q11.2DS) have a 25-30% risk of developing schizophrenia, and also suffer frequent hearing loss. Here, we used the Df1/+ mouse model of 22q11.2DS to investigate the relationship between hearing loss and susceptibility to schizophrenia-relevant brain and behavioral abnormalities. Df1/+ mice have a multi-gene deletion analogous to the chromosomal microdeletion that causes human 22q11.2DS, and like human 22q11.2DS patients exhibit high rates of hearing loss arising primarily from susceptibility to middle ear inflammation. We found that hearing loss in Df1/+ mice affected schizophrenia-relevant endophenotypes, including electrophysiological measures of central auditory gain and behavioral measures of auditory sensorimotor gating. Moreover, PV+ inhibitory interneurons, another marker for schizophrenia pathology, were significantly reduced in density in auditory cortex but not secondary motor cortex of Df1/+ mice with hearing loss. These results reveal bottom-up neurobiological mechanisms through which peripheral hearing loss arising from the 22q11.2 deletion may promote the emergence of schizophrenia-relevant auditory brain and behavioral abnormalities, and also suggest a link between conductive hearing loss and reduced PV+ interneuron density in the auditory cortex.SIGNIFICANCE STATEMENTHearing loss is a known risk factor for schizophrenia. Deletion of chromosomal locus 22q11.2 is associated with both schizophrenia and hearing loss in humans. In the Df1/+ mouse model of human 22q11.2 Deletion Syndrome, we find that hearing loss shapes measures that are considered schizophrenia-relevant endophenotypes, such as central auditory gain and auditory sensorimotor gating. Moreover, we report a reduction in density of PV+ inhibitory interneurons in the auditory cortex, but not secondary motor cortex, of Df1/+ mice with hearing loss. These results suggest mechanisms through which hearing loss associated with the 22q11.2 deletion may promote emergence of schizophrenia-relevant auditory brain and behavioral abnormalities and indicate that conductive hearing loss may influence PV+ interneuron density in the auditory cortex.

Behavioral and Electrophysiologic Binaural Processing in Persons with Symmetric Hearing Loss

2011 ◽  
Vol 22 (03) ◽  
pp. 181-193 ◽  
Author(s):  
Elizabeth D. Leigh-Paffenroth ◽  
Christina M. Roup ◽  
Colleen M. Noe
Keyword(s):  
Hearing Loss ◽  
Hearing Aids ◽  
Auditory Processing ◽  
Repeated Measures ◽  
Pure Tone ◽  
Binaural Hearing ◽  
Behavioral Tests ◽  
Binaural Processing ◽  
Binaural Interaction ◽  
Noise Test

Background: Binaural hearing improves our ability to understand speech and to localize sounds. Hearing loss can interfere with binaural cues, and despite the success of amplification, ˜25% of people with bilateral hearing loss fit with two hearing aids choose to wear only one (e.g., Brooks and Bulmer, 1981). One explanation is reduced binaural processing, which occurs when the signal presented to one ear interferes with the perception of the signal presented to the other ear (e.g., Jerger et al, 1993). Typical clinical measures, however, are insensitive to binaural processing deficits. Purpose: The purpose of this study was to determine the extent to which behavioral measures of binaural performance were related to electrophysiological measures of binaural processing in subjects with symmetrical pure-tone sensitivity. Research Design: The relationship between middle latency responses (MLRs) and behavioral performance on binaural listening tasks was assessed by Spearman's rho correlation analyses. Separate repeated measures analyses of variance (RMANOVAs) were performed for MLR latency and MLR amplitude. Study Sample: Nineteen subjects were recruited for the present study based on a clinical presentation of symmetrical pure-tone sensitivity with asymmetrical performance on a word-recognition in noise test. This subpopulation of patients included both subjects with and subjects without hearing loss. Data Collection and Analysis: Monaural and binaural auditory processing was measured behaviorally and electrophysiologically in right-handed subjects. The behavioral tests included the Words-in-Noise test (WIN), the dichotic digits test (DDT), and the 500 Hz masking level difference (MLD). Electrophysiologic responses were measured by the binaural interaction component (BIC) of the MLR. The electrophysiological responses were analyzed to examine the effects of peak (Na, Pa, and Nb) and condition (monaural left, monaural right, binaural, and BIC) on MLR amplitude and latency. Results: Significant correlations were found among electrophysiological measures of binaural hearing and behavioral tests of binaural hearing. A strong correlation between the MLD and the binaural Na-Pa amplitude was found (r = .816). Conclusions: The behavioral and electrophysiological measures used in the present study clearly showed evidence of reduced binaural processing in ˜10 of the subjects in the present study who had symmetrical pure-tone sensitivity. These results underscore the importance of understanding binaural auditory processing and how these measures may or may not identify functional auditory problems.

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