Association of Red Meat and Poultry Consumption With the Risk of Metabolic Syndrome: A Meta-Analysis of Prospective Cohort Studies

Objective: This study aims to investigate the association of red meat (processed and unprocessed) and poultry consumption with the risk of metabolic syndrome (MetS).Methods: Prospective cohort studies on the association of red meat (processed and unprocessed) and poultry consumption with the risk of MetS were identified by comprehensive literature search in the PubMed, Web of Science, and Embase databases up to March 2021. The pooled relative risk (RR) of MetS with 95% CIs for the highest vs. lowest category of red meat or poultry consumption was extracted for meta-analysis.Results: A total of nine prospective cohort studies were included in this study. Among them, eight studies were identified for red meat consumption. The overall multi-variable adjusted RR demonstrated that red meat consumption was associated with a higher risk of MetS (RR = 1.35, 95% CI: 1.13–1.62; P = 0.001). Moreover, four and three studies were specifically related to processed and unprocessed red meat consumption, respectively. Both processed (RR = 1.48, 95% CI: 1.11–1.97; P = 0.007) and unprocessed red meat (RR = 1.32, 95% CI: 1.14–1.54; P = 0.0003) consumption was associated with a higher risk of MetS. With regard to poultry consumption, three studies were included. The overall multi-variable adjusted RR suggested that poultry consumption was associated with lower risk of MetS (RR = 0.85, 95% CI: 0.75–0.97; P = 0.02).Conclusions: The current evidence indicates that red meat (processed and unprocessed) consumption is associated with a higher risk of MetS, whereas, poultry consumption is associated with a lower risk of MetS. More well-designed randomized controlled trials are still needed to address the issues further.

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Red Meat Consumption and the Risk of Stroke: A Dose–Response Meta-analysis of Prospective Cohort Studies

Journal of Stroke and Cerebrovascular Diseases ◽

10.1016/j.jstrokecerebrovasdis.2016.01.040 ◽

2016 ◽

Vol 25 (5) ◽

pp. 1177-1186 ◽

Cited By ~ 38

Author(s):

Cuili Yang ◽

Lei Pan ◽

Chengcao Sun ◽

Yongyong Xi ◽

Liang Wang ◽

...

Keyword(s):

Cohort Studies ◽

Dose Response ◽

Prospective Cohort ◽

Meta Analysis ◽

Meat Consumption ◽

Red Meat ◽

Prospective Cohort Studies

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Faculty Opinions recommendation of Effects of cyclophosphamide on pulmonary function in patients with scleroderma and interstitial lung disease: a systematic review and meta-analysis of randomized controlled trials and observational prospective cohort studies.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1158170.618084 ◽

2009 ◽

Author(s):

Ladislav Senolt ◽

Michal Tomcikq

Keyword(s):

Systematic Review ◽

Interstitial Lung Disease ◽

Pulmonary Function ◽

Cohort Studies ◽

Randomized Controlled Trials ◽

Prospective Cohort ◽

Meta Analysis ◽

Controlled Trials ◽

Prospective Cohort Studies ◽

Randomized Controlled

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Metabolic syndrome and the risk of bone fractures: A Meta-analysis of prospective cohort studies

Bone ◽

10.1016/j.bone.2015.12.008 ◽

2016 ◽

Vol 84 ◽

pp. 52-56 ◽

Cited By ~ 10

Author(s):

Libo Yang ◽

Xiaohong Lv ◽

Dailin Wei ◽

Feng Yue ◽

Jinying Guo ◽

...

Keyword(s):

Metabolic Syndrome ◽

Cohort Studies ◽

Prospective Cohort ◽

Bone Fractures ◽

Meta Analysis ◽

Prospective Cohort Studies

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ENDOCRINOLOGY IN PREGNANCY: Thyroid antibodies and risk of preterm delivery: a meta-analysis of prospective cohort studies

Acta Endocrinologica ◽

10.1530/eje-12-0379 ◽

2012 ◽

Vol 167 (4) ◽

pp. 455-464 ◽

Cited By ~ 51

Author(s):

Xiaoyan He ◽

Pingping Wang ◽

Zengfang Wang ◽

Xiaoqin He ◽

Donghua Xu ◽

...

Keyword(s):

Cohort Studies ◽

Pregnant Women ◽

Preterm Delivery ◽

Prospective Cohort ◽

Thyroid Dysfunction ◽

Reference Group ◽

Meta Analysis ◽

Current Evidence ◽

Thyroid Antibodies ◽

Prospective Cohort Studies

BackgroundObservational studies suggest possible associations between thyroid antibodies and risk of preterm delivery. However, whether thyroid antibodies are risk factors of preterm labor remains controversial. Our goal was to evaluate the associations between thyroid antibodies and risk of preterm delivery by conducting a meta-analysis of prospective cohort studies.MethodsPubMed, Embase, and Wangfang databases were searched through January 2012 to identify studies that met pre-stated inclusion criteria. Data were extracted using standardized forms. Either a fixed- or a random-effects model was used to calculate the overall combined relative ratio (RR) with its corresponding 95% confidence interval (95% CI) to evaluate the relationship between thyroid antibodies and preterm delivery risk. Subgroup analyses were mainly performed by type of thyroid antibodies including thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibody (TG-Ab).ResultsEleven prospective cohort studies involving 35 467 participants were included. The combined RR of preterm delivery for pregnant women with thyroid antibodies compared with the reference group was 1.41 (95% CI 1.08–1.84, P=0.011). Subgroup analysis yielded the combined RR of preterm delivery for pregnant women with TPO-Ab compared with the reference group was 1.69 (95% CI 1.19–2.41, P=0.003), whereas pregnant women with positive TG-Ab had no obvious risk of preterm delivery compared with the reference group (RR=0.88, 95% CI 0.60–1.29, P=0.513). Sensitivity analysis restricted to studies excluding women with thyroid dysfunction yielded similar results. Meta-regression analysis suggested that the status of exclusion or inclusion of women with thyroid dysfunction was the major source of heterogeneity in this meta-analysis. No evidence of publication bias was observed.ConclusionsCurrent evidence suggests that the presence of TPO-Ab in pregnant women significantly increases the risk of preterm delivery.

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Associations of Whole Grain and Refined Grain Consumption With Metabolic Syndrome. A Meta-Analysis of Observational Studies

Frontiers in Nutrition ◽

10.3389/fnut.2021.695620 ◽

2021 ◽

Vol 8 ◽

Author(s):

Hongbin Guo ◽

Jun Ding ◽

Jieyu Liang ◽

Yi Zhang

Keyword(s):

Metabolic Syndrome ◽

Cohort Studies ◽

Prospective Cohort ◽

Observational Studies ◽

Meta Analysis ◽

Epidemiological Studies ◽

Whole Grain ◽

Cross Sectional ◽

Prospective Cohort Studies ◽

Embase Database

Background: The associations of whole grain and refined grain consumption with metabolic syndrome (MetS) has been evaluated in several epidemiological studies with conflicting results. This meta-analysis was therefore employed to further investigate the above associations.Method: We searched the PubMed, Web of Science and Embase database until March 2021 (without restriction for inclusion time), for observational studies on the associations of whole grain and refined grain consumption with MetS. The pooled relative risk (RR) of MetS for the highest vs. lowest category of whole grain and refined grain consumption, as well as their corresponding 95% confidence interval (CI) were calculated.Results: A total of 14 observational studies, which involved seven cross-sectional and seven prospective cohort studies, were identified. Specifically, nine studies were related to whole grain consumption, and the overall multi-variable adjusted RR demonstrated that the whole grain consumption was inversely associated with MetS (RR = 0.80, 95%CI: 0.67–0.97; P = 0.021). With regard to refined grain consumption, 13 studies were included. The overall multi-variable adjusted RR indicated that refined grain consumption was positively associated with MetS (RR = 1.37, 95%CI: 1.02–1.84; P = 0.036).Conclusions: The existing evidence suggests that whole grain consumption is negatively associated with MetS, whereas refined grain consumption is positively associated with MetS. Our result might be helpful to better consider the diet effect on MetS. However, more well-designed prospective cohort studies are needed to elaborate the concerned issues further.

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Faculty Opinions recommendation of Red meat consumption and mortality: results from 2 prospective cohort studies.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14141956.15635056 ◽

2012 ◽

Author(s):

Mikael Fogelholm

Keyword(s):

Cohort Studies ◽

Prospective Cohort ◽

Meat Consumption ◽

Red Meat ◽

Prospective Cohort Studies

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Faculty Opinions recommendation of Association of changes in red meat consumption with total and cause specific mortality among US women and men: two prospective cohort studies.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735974161.793561324 ◽

2019 ◽

Author(s):

Michael Symonds

Keyword(s):

Cohort Studies ◽

Prospective Cohort ◽

Meat Consumption ◽

Red Meat ◽

Prospective Cohort Studies ◽

Specific Mortality

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Abstract P225: The Associations of Dietary and Biomarkers of Linoleic Acid Intake and All-cause and Cardiovascular Mortality: A Systematic Review and Meta-analysis

Circulation ◽

10.1161/circ.137.suppl_1.p225 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Jun Li ◽

Marta Guasch-Ferré ◽

Yanping Li ◽

Frank Hu

Keyword(s):

Systematic Review ◽

Linoleic Acid ◽

Cohort Studies ◽

Prospective Cohort ◽

Lower Risk ◽

Meta Analysis ◽

Dietary Survey ◽

Prospective Cohort Studies ◽

All Cause Mortality ◽

Cvd Mortality

Background: Previous studies on intake of linoleic acid (LA), a predominant n-6 fatty acid, and risk of mortality from all-cause and cardiovascular disease (CVD) have generated inconsistent results. We performed a systematic review and meta-analysis of prospective cohort studies to summarize the evidence regarding the relation of LA and all-cause and CVD mortality. Methods: We searched MEDLINE and EMBASE databases through June 2017 for prospective cohort studies reporting association of LA (assessed by dietary survey or biomarker in blood or adipose tissue) with all-cause and CVD mortality. In addition, unpublished data from pooling projects were included. We pooled the multivariate-adjusted Hazards ratios (HRs) using random-effect meta-analysis, which allowed for between-study heterogeneity. Results: 27 studies covering 37 prospective cohorts were identified; these included 274,565 individuals with dietary assessment (34,597 all-cause and 10,636 CVD deaths) and 54,794 individuals with biomarker measurements (6,767 all-cause and 5,311 CVD deaths). Comparing the highest category with the lowest, dietary LA intake was associated with a 14% lower risk of all-cause mortality (95% confidence interval [CI], 2%-25%, I 2 =71%) and a 20% lower risk of CVD mortality (95% CI, 13%-26%, I 2 =0). Baseline health status (i.e. general population, CVD/high risk for CVD, or cancer) might be a main source of heterogeneity for the association of dietary LA intake with all-cause mortality. As for biomarkers, 1 SD increment in LA was associated with a 9% lower risk of all-cause mortality (95% CI, 4%-14%, I 2 =61%) and a 10% lower risk of CVD mortality (95% CI, 5%-14%, I 2 =13%). Heterogeneity was presented across tissue types and between genders. Conclusions: In prospective cohort studies, LA intake, assessed by either dietary survey or biomarkers, was inversely associated with all-cause and CVD mortality in a dose-response manner. These data support the current recommendations on polyunsaturated fat intake for prevention of CVD and early death.

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