Children Conceived by Assisted Reproductive Technology Prone to Low Birth Weight, Preterm Birth, and Birth Defects: A Cohort Review of More Than 50,000 Live Births During 2011–2017 in Taiwan

AbstractObjectivesThe purpose of this study was to compare the rate of preterm birth, low birth weight, and foetal growth restriction in assisted reproductive technology (ART) singleton pregnancies diagnosed with vanishing twin (VT) syndrome to those of ART pregnancies that were originally singleton pregnancies.MethodsIn this retrospective study, 177 pregnancies diagnosed with VT syndrome were matched and compared with 218 primary singleton pregnancies. The preterm birth and low birth weight rates of these two groups were evaluated. All pregnancies were conceived through ART and delivered at Peking University First Hospital and Hebei Xingtai Infertility Hospital from 2014 to 2016.ResultsThe preterm delivery rate (20.90 vs. 8.72%, p<0.05) was significantly higher in the ART singletons with VT syndrome than in the control singleton group. The proportion of low-birth-weight (<2500 g) infants was also higher in the VT group than in the primary singleton group (10.73 vs. 3.67%, p<0.05). In addition, the preterm birth rate of the naturally conceived singletons was significantly lower than that of the ART singletons (6.00 vs. 14.18%, p<0.05).ConclusionsART singleton pregnancies with VT syndrome have higher rates of preterm birth and low-birth-weight new-borns than ART pregnancies that were originally singleton pregnancies.

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Preterm birth and low birth weight after assisted reproductive technology-related pregnancy in Australia between 1996 and 2000

Fertility and Sterility ◽

10.1016/j.fertnstert.2004.12.033 ◽

2005 ◽

Vol 83 (6) ◽

pp. 1650-1658 ◽

Cited By ~ 116

Author(s):

Yueping Alex Wang ◽

Elizabeth A. Sullivan ◽

Deborah Black ◽

Jishan Dean ◽

Joanne Bryant ◽

...

Keyword(s):

Birth Weight ◽

Preterm Birth ◽

Low Birth Weight ◽

Assisted Reproductive Technology ◽

Reproductive Technology

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Pregnancy Outcome during the First COVID 19 Lockdown in Vienna, Austria

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18073782 ◽

2021 ◽

Vol 18 (7) ◽

pp. 3782

Author(s):

Sylvia Kirchengast ◽

Beda Hartmann

Keyword(s):

Birth Weight ◽

Preterm Birth ◽

Low Birth Weight ◽

Pregnancy Outcome ◽

Gestational Age ◽

Very Low Birth Weight ◽

Extremely Low Birth Weight ◽

Negative Effects ◽

Gestational Length ◽

Live Births

The COVID 19 pandemic represents a major stress factor for non-infected pregnant women. Although maternal stress during pregnancy increases the risk of preterm birth and intrauterine growth restriction, an increasing number of studies yielded no negative effects of COVID 19 lockdowns on pregnancy outcome. The present study focused on pregnancy outcome during the first COVID 19 lockdown phase in Austria. In particular, it was hypothesized that the national lockdown had no negative effects on birth weight, low birth weight rate and preterm birth rate. In a retrospective medical record-based single center study, the outcome of 669 singleton live births in Vienna Austria during the lockdown phase between March and July 2020 was compared with the pregnancy outcome of 277 live births at the same hospital during the pre-lockdown months of January and February 2020 and, in addition, with the outcome of 28,807 live births between 2005 and 2019. The rate of very low gestational age was significantly lower during the lockdown phase than during the pre-lockdown phase. The rate of low gestational age, however, was slightly higher during the lockdown phase. Mean birth weight was significantly higher during the lockdown phase; the rates of low birth weight, very low birth weight and extremely low birth weight were significantly lower during the lockdown phase. In contrast, maternal gestational weight gain was significantly higher during the lockdown phase. The stressful lockdown phase in Austria seems to have no negative affect on gestational length and newborn weight among non-infected mothers.

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Low and Very Low Birth Weight in Infants Conceived with Use of Assisted Reproductive Technology

New England Journal of Medicine ◽

10.1056/nejmoa010806 ◽

2002 ◽

Vol 346 (10) ◽

pp. 731-737 ◽

Cited By ~ 621

Author(s):

Laura A. Schieve ◽

Susan F. Meikle ◽

Cynthia Ferre ◽

Herbert B. Peterson ◽

Gary Jeng ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Assisted Reproductive Technology ◽

Very Low Birth Weight ◽

Reproductive Technology

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High-risk of preterm birth and low birth weight after oocyte donation IVF: analysis of 133,785 live births

Reproductive BioMedicine Online ◽

10.1016/j.rbmo.2017.06.013 ◽

2017 ◽

Vol 35 (3) ◽

pp. 318-324 ◽

Cited By ~ 8

Author(s):

Mohan Shashikant Kamath ◽

Belavendra Antonisamy ◽

Mariano Mascarenhas ◽

Sesh Kamal Sunkara

Keyword(s):

Birth Weight ◽

Preterm Birth ◽

High Risk ◽

Low Birth Weight ◽

Oocyte Donation ◽

Live Births

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Changes in live births, preterm birth, low birth weight, and cesarean deliveries in the United States during the SARS-CoV-2 pandemic

10.1101/2021.03.20.21253990 ◽

2021 ◽

Author(s):

Alison Gemmill ◽

Joan A. Casey ◽

Ralph Catalano ◽

Deborah Karasek ◽

Tim-Allen Bruckner

Keyword(s):

Time Series ◽

Birth Weight ◽

Preterm Birth ◽

Low Birth Weight ◽

Cesarean Delivery ◽

Very Low Birth Weight ◽

National Level ◽

Health Indicators ◽

The United States ◽

Live Births

Background: The SARS-CoV-2 pandemic and associated social, economic, and clinical disruption have been widely speculated to affect pregnancy decision-making and outcomes. While a few US-based studies have examined subnational changes in fertility, preterm birth, and stillbirth, there remains limited knowledge of how the pandemic impacted childbearing and a broader set of perinatal health indicators at the national-level throughout 2020. Here, we use recently released national-level data to fill this gap. Importantly, we, unlike earlier work, use time-series methods to account for strong temporal patterning (e.g., seasonality, trend) that could otherwise lead to spurious findings. Methods: For the years 2015 to 2020, we obtained national monthly counts of births and rates (per 100 births) for six perinatal indicators: preterm birth (<37 weeks gestation), early preterm birth (<34 weeks gestation), late preterm birth (34-36 weeks gestation), low birth weight birth (<2500 g), very low birth weight birth (<1500 g), and cesarean delivery. We use an interrupted time-series approach to compare the outcomes observed after the pandemic began (March 2020) to those expected had the pandemic not occurred. Results: For total births as well as five of the six indicators (i.e., all but the rate of cesarean delivery), observed values fall well below expected levels (p<.0001 for each test) during the entire pandemic period. Declines in preterm birth and low birth weight were largest in magnitude in both early and later stages of the 2020 pandemic, while those for live births occurred at the end of the year. Discussion: Our findings provide some of the first national evidence of substantial reductions in live births and adverse perinatal outcomes during the SARS-CoV-2 pandemic. Only cesarean delivery appeared unaffected. These declines were not uniform across the pandemic, suggesting that several mechanisms, which require further study, may explain these patterns.

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Contribution of assisted reproductive technology (ART) to multiple births, preterm, and low birth weight infants, U.S., 2010

Fertility and Sterility ◽

10.1016/j.fertnstert.2013.07.1740 ◽

2013 ◽

Vol 100 (3) ◽

pp. S91

Author(s):

S. Sunderam ◽

D.M. Kissin ◽

S. Crawford ◽

J. Anderson ◽

D.J. Jamieson ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Assisted Reproductive Technology ◽

Reproductive Technology ◽

Multiple Births ◽

Low Birth Weight Infants

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The association between endometriosis and the risk of LBW: A meta-analysis

Journal of Endometriosis and Pelvic Pain Disorders ◽

10.1177/2284026518774997 ◽

2018 ◽

Vol 10 (2) ◽

pp. 72-78 ◽

Cited By ~ 2

Author(s):

Ensiyeh Jenabi ◽

Bita Fereidooni

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Cohort Studies ◽

Assisted Reproductive Technology ◽

Subgroup Analysis ◽

Odds Ratio ◽

Web Of Science ◽

Meta Analysis ◽

Reproductive Technology ◽

Random Effects Model

Background: Many observational services have been conducted to evaluate the risk factors of low birth weight, but the results showed no consistency. Therefore, we conducted this meta-analysis to investigate the association between endometriosis (body mass index) and the risk of low birth weight. Methods: Relevant works that were published in major international electronic databases such as PubMed, Scopus, Web of Science, LILACS, SciELO, and Cochrane were systematically searched until February 2018. Begg’s and Egger’s tests were used to determine publication bias in included studies. The random-effects model was carried out to determine the odds ratio. Results: A meta-analysis of the 12 studies proposed a significant association between endometriosis and the risk of low birth weight (odds ratio = 1.34, 95% confidence interval = 1.08–1.60). The subgroup analysis was carried out based on the design, adjusted form, and use of assisted reproductive technology in studies. The pooled results based on subgroup analysis in case–control and cohort studies were 1.46 (0.79–2.12) and 1.32 (1.02–1.62), respectively. There was significant correlation between endometriosis and low birth weight in cohort studies. Also, heterogeneity was not reported among studies in the subgroup based on adjusted form. There was no significant correlation between endometriosis and low birth weight in studies using assisted reproductive technology methods Conclusion: The systematic review and meta-analysis showed that endometriosis increases the risk of low birth weight. Therefore, it is a risk factor for low birth weight.

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Prevention of Preterm Births: A Perinatal Study in Haguenau, France

PEDIATRICS ◽

10.1542/peds.76.2.154 ◽

1985 ◽

Vol 76 (2) ◽

pp. 154-158

Author(s):

E. Papiernik ◽

J. Bouyer ◽

J. Dreyfus ◽

D. Collin ◽

G. Winisdorffer ◽

...

Keyword(s):

Birth Weight ◽

Preterm Birth ◽

Low Birth Weight ◽

Direct Relationship ◽

Intervention Study ◽

Total Duration ◽

Preterm Births ◽

Birth Rates ◽

Live Births ◽

Mother’S Age

A reduction in preterm births has been observed in Haguenau (Eastern France) during a 12-year intervention study with a program for prevention of preterm deliveries. The Perinatal Study of Haguenau was an observation tool used in a stable population, and it allowed measurement of the way women have progressively responded to the new proposals in prenatal care. It also allowed measurement of the results of the interventions: low birth weight (less than 2,500 g) and preterm birth rates (less than 37 weeks of gestation) among single live births. The total duration of the study was divided into three periods of four years (1971 through 1974, 1975 through 1978, and 1979 through 1982), for which the numbers of single live births are 5,763, 4,957, and 5,919, respectively. For the same periods, the low-birth-weight rates, 4.6%, 4.0%, and 3.8%, respectively, showed a significant decrease (P < .001). Following a similar pattern, the rates of preterm birth were 5.4%, 4.1%, and 3.7% (a significant reduction with P < .001). These improvements in pregnancy outcome do not disappear after standardization of mother's age, high blood pressure, or social class distribution. These findings, which concur with the results of others, enhance the hypothesis of a direct relationship between a prevention program and a reduction in preterm birth rates.

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