Case Report: 18F-FDG PET-CT for Diagnosing Prosthetic Device-Related Infection in an Infant With CHD

Patients who have undergone cardiac surgery using prosthetic devices have an increased risk of developing prosthetic device-related infection and mediastinitis. However, accurate diagnosis of prosthetic device-related infection can be difficult to evaluate and treat with antibiotic therapy alone. In recent years, 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) has made promising contributions to detect infective endocarditis, pacemaker infections, or other inflammations. Nevertheless, 18F-FDG PET-CT for congenital heart disease (CHD) with device infection has been sparsely reported. We present an infantile girl diagnosed with pulmonary atresia with a ventricular septal defect who underwent replacement of the right ventricle-to-pulmonary artery (RV-PA) conduit for improvement cyanosis. She developed high fever and was diagnosed with mediastinitis and bacteremia by Pseudomonas aeruginosa (P. aeruginosa) on postoperative day 4. Mediastinal drainage and 6 weeks of antibiotic therapy improved her condition, but bacteremia flared up on postoperative day 56. Despite a long course of antibiotic therapy, she had two more recurrences of bacteremia with the detection of P. aeruginosa. Echocardiography and chest contrast CT showed no evidence of vegetation and mediastinitis. On postoperative day 115, 18F-FDG PET-CT revealed an accumulation on the RV-PA conduit (SUV max 3.4). Finally, she developed an infectious ventricular pseudo-aneurysm on postoperative day 129 and underwent aneurysm removal and RV-PA conduit replacement on postoperative day 136. Our case showed the importance of 18F-FDG PET-CT for diagnosing specific localization of prosthetic device-related infection which is hard to detect using other imaging techniques. It can be a useful diagnostic tool for infantile patients with CHD with cardiac prosthetic devices and improve subsequent clinical treatments.

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The utility of FDG-PET/CT and other imaging techniques in the evaluation of IgG4-related disease

Joint Bone Spine ◽

10.1016/j.jbspin.2014.01.010 ◽

2014 ◽

Vol 81 (4) ◽

pp. 331-336 ◽

Cited By ~ 31

Author(s):

Hiroyuki Takahashi ◽

Hiroyuki Yamashita ◽

Miyako Morooka ◽

Kazuo Kubota ◽

Yuko Takahashi ◽

...

Keyword(s):

Fdg Pet ◽

Imaging Techniques ◽

Related Disease ◽

Igg4 Related Disease ◽

Pet Ct ◽

Fdg Pet Ct

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[68Ga] Ga-DOTA-FAPI-04 And [18F] FDG PET / CT For Diagnosis of Metastatic Lesions In Patients With Recurrent Papillary Thyroid Carcinoma

10.21203/rs.3.rs-742144/v1 ◽

2021 ◽

Author(s):

Umut Elboğa ◽

Zeynel Abidin Sayiner ◽

Ertan Şahin ◽

Saadettin Öztürk ◽

Yusuf Burak Çayırlı ◽

...

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Fdg Pet ◽

Imaging Techniques ◽

Statistical Significance ◽

Ct Imaging ◽

Papillary Thyroid ◽

Metastatic Focus ◽

Pet Ct ◽

Fdg Pet Ct

Abstract Context: PET CT imaging methods based on fibroblast activation protein inhibitors (FAPIs) have recently demonstrated promising clinical results. Objective: We aimed to evaluate the use of 68Ga-FAPI PET / CT and 18FDG PET / CT imaging techniques to detect the metastatic foci in recurrent papillary thyroid carcinoma.Design and Patients: This is a prospective study. Patients who were diagnosed with papillary thyroid carcinoma, achieved biochemical recovery after the first operation and having recurrence for papillary thyroid carcinoma on the follow up were included in the study. [68Ga] Ga-DOTA-FAPI-04 and [18F] FDG PET / CT were performed for comparative purpose and detection of recurrence localization.Results: [18F] FDG PET / CT detected the metastatic foci in 21 of 29 patients (72.4%), [68Ga] Ga-DOTA-FAPI-04 was able to detect the metastatic foci in 25 of 29 patients (86.2%). When the two imaging techniques were used together, the metastatic foci in 27 of the 29 patients could be detected (93.1%.). Also between the [18F] FDG PET / CT SUVmax values and [68Ga] Ga-DOTA-FAPI-04 SUVmax values, a statistical significance was found in favor of 68Ga-FAPI PET (p = 0,002).Conclusion: In conclusion, 68Ga-FAPI PET imaging technique can be used as an alternative method to detect the metastatic focus or foci in patients with recurrent papillary thyroid carcinoma. It can also increase the chance of metastatic focus or foci detection when used in conjunction with the 18 FDG PET.

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Nuclear Imaging in Infective Endocarditis

Pharmaceuticals ◽

10.3390/ph15010014 ◽

2021 ◽

Vol 15 (1) ◽

pp. 14

Author(s):

Nidaa Mikail ◽

Fabien Hyafil

Keyword(s):

Computed Tomography ◽

Infective Endocarditis ◽

Fdg Pet ◽

Imaging Techniques ◽

Nuclear Imaging ◽

Emission Tomography ◽

Cardiac Devices ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Infective endocarditis (IE) is a life-threatening disease with stable prevalence despite prophylactic, diagnostic, and therapeutic advances. In parallel to the growing number of cardiac devices implanted, the number of patients developing IE on prosthetic valves and cardiac implanted electronic device (CIED) is increasing at a rapid pace. The diagnosis of IE is particularly challenging, and currently relies on the Duke-Li modified classification, which include clinical, microbiological, and imaging criteria. While echocardiography remains the first line imaging technique, especially in native valve endocarditis, the incremental value of two nuclear imaging techniques, 18F-fluorodeoxyglucose positron emission tomography with computed tomography (18F-FDG-PET/CT) and white blood cells single photon emission tomography with computed tomography (WBC-SPECT), has emerged for the management of prosthetic valve and CIED IE. In this review, we will summarize the procedures for image acquisition, discuss the role of 18F-FDG-PET/CT and WBC-SPECT imaging in different clinical situations of IE, and review the respective diagnostic performance of these nuclear imaging techniques and their integration into the diagnostic algorithm for patients with a suspicion of IE.

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The role of FDG PET/CT in patients with locoregional breast cancer recurrence: A comparison to conventional imaging techniques

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2009.11.009 ◽

2010 ◽

Vol 36 (4) ◽

pp. 387-392 ◽

Cited By ~ 61

Author(s):

T.S. Aukema ◽

E.J.Th. Rutgers ◽

W.V. Vogel ◽

H.J. Teertstra ◽

H.S. Oldenburg ◽

...

Keyword(s):

Breast Cancer ◽

Fdg Pet ◽

Imaging Techniques ◽

Cancer Recurrence ◽

Breast Cancer Recurrence ◽

Conventional Imaging ◽

Pet Ct ◽

Fdg Pet Ct

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The usefulness of repeated CMR and FDG PET/CT in the diagnosis of patients with initial possible cardiac sarcoidosis

EJNMMI Research ◽

10.1186/s13550-021-00870-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

H. Mathijssen ◽

T. W. H. Tjoeng ◽

R. G. M. Keijsers ◽

A. L. M. Bakker ◽

F. Akdim ◽

...

Keyword(s):

Fdg Pet ◽

Cardiac Sarcoidosis ◽

Imaging Techniques ◽

Immunosuppressive Treatment ◽

Imaging Modalities ◽

Fdg Uptake ◽

Positron Emission ◽

Pet Ct ◽

Fdg Pet Ct ◽

Lge Cmr

Abstract Background Cardiac sarcoidosis (CS) diagnosis is usually based on advanced imaging techniques and multidisciplinary evaluation. Diagnosis is classified as definite, probable, possible or unlikely. If diagnostic confidence remains uncertain, cardiac imaging can be repeated. The objective is to evaluate the usefulness of repeated cardiac magnetic resonance imaging (CMR) and fluorodeoxyglucose positron emission tomography (FDG PET/CT) for CS diagnosis in patients with an initial “possible” CS diagnosis. Methods We performed a retrospective cohort study in 35 patients diagnosed with possible CS by our multidisciplinary team (MDT), who received repeated CMR and FDG PET/CT within 12 months after diagnosis. Imaging modalities were scored on abnormalities suggestive for CS and classified as CMR+/PET+, CMR+/PET−, CMR−/PET+ and CMR−/PET−. Primary endpoint was final MDT diagnosis of CS. Results After re-evaluation, nine patients (25.7%) were reclassified as probable CS and 16 patients (45.7%) as unlikely CS. Two patients started immunosuppressive treatment after re-evaluation. At baseline, eleven patients (31.4%) showed late gadolinium enhancement (LGE) on CMR (CMR+) and 26 (74.3%) patients showed myocardial FDG-uptake (PET+). At re-evaluation, nine patients (25.7%) showed LGE (CMR+), while 16 patients (45.7%) showed myocardial FDG-uptake (PET+). When considering both imaging modalities together, 82.6% of patients with CMR−/PET+ at baseline were reclassified as possible or unlikely CS, while 36.4% of patients with CMR+ at baseline were reclassified as probable CS. Three patients with initial CMR−/PET+ showed LGE at re-evaluation. Conclusion Repeated CMR and FDG PET/CT may be useful in establishing or rejecting CS diagnosis, when initial diagnosis is uncertain. However, clinical relevance has to be further determined.

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Incremental diagnostic value of [18F]tetrafluoroborate PET-CT compared to [131I]iodine scintigraphy in recurrent differentiated thyroid cancer

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-020-04727-9 ◽

2020 ◽

Vol 47 (11) ◽

pp. 2639-2646 ◽

Cited By ~ 2

Author(s):

Matthias Dittmann ◽

José Manuel Gonzalez Carvalho ◽

Kambiz Rahbar ◽

Michael Schäfers ◽

Michael Claesener ◽

...

Keyword(s):

Thyroid Cancer ◽

Fdg Pet ◽

Differentiated Thyroid Cancer ◽

Imaging Techniques ◽

Diagnostic Value ◽

Whole Body ◽

Sodium Iodide Symporter ◽

Cervical Lymph Nodes ◽

Pet Ct ◽

Fdg Pet Ct

Abstract Introduction Efficient therapy of recurrent differentiated thyroid cancer (DTC) is dependent on precise molecular imaging techniques targeting the human sodium iodide symporter (hNIS), which is a marker both of thyroid and DTC cells. Various iodine isotopes have been utilized for detecting DTC; however, these come with unfavorable radiation exposure and image quality ([131I]iodine) or limited availability ([124I]iodine). In contrast, [18F]tetrafluoroborate (TFB) is a novel radiolabeled PET substrate of hNIS, results in PET images with high-quality and low radiation doses, and should therefore be suited for imaging of DTC. The aim of the present study was to compare the diagnostic performance of [18F]TFB-PET to the clinical reference standard [131I]iodine scintigraphy in patients with recurrent DTC. Methods Twenty-five patients with recurrent DTC were included in this retrospective analysis. All patients underwent [18F]TFB-PET combined with either CT or MRI due to newly discovered elevated TG levels, antiTG levels, sonographically suspicious cervical lymph nodes, or combinations of these findings. Correlative [131I]iodine whole-body scintigraphy (dxWBS) including SPECT-CT was present for all patients; correlative [18F]FDG-PET-CT was present for 21 patients. Histological verification of [18F]TFB positive findings was available in 4 patients. Results [18F]TFB-PET detected local recurrence or metastases of DTC in significantly more patients than conventional [131I]iodine dxWBS and SPECT-CT (13/25 = 52% vs. 3/25 = 12%, p = 0.002). The diagnosis of 6 patients with cervical lymph node metastases that showed mildly increased FDG metabolism but negative [131I]iodine scintigraphy was changed: [18F]TFB-PET revealed hNIS expression in the metastases, which were therefore reclassified as only partly de-differentiated (histological confirmation present in two patients). Highest sensitivity for detecting recurrent DTC had the combination of [18F]TFB-PET-CT/MRI with [18F]FDG-PET-CT (64%). Conclusion In the present cohort, [18F]TFB-PET shows higher sensitivity and accuracy than [131I]iodine WBS and SPECT-CT in detecting recurrent DTC. The combination of [18F]TFB-PET with [18F]FDG-PET-CT seems a reasonable strategy to characterize DTC tumor manifestations with respect to their differentiation and thereby also individually plan and monitor treatment. Future prospective studies evaluating the potential of [18F]TFB-PET in recurrent DTC are warranted.

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Multimodality Functional Imaging in Radiation Therapy Planning: Relationships between Dynamic Contrast-Enhanced MRI, Diffusion-Weighted MRI, and 18F-FDG PET

Computational and Mathematical Methods in Medicine ◽

10.1155/2015/103843 ◽

2015 ◽

Vol 2015 ◽

pp. 1-10 ◽

Cited By ~ 4

Author(s):

Moisés Mera Iglesias ◽

David Aramburu Núñez ◽

José Luis del Olmo Claudio ◽

Antonio López Medina ◽

Iago Landesa-Vázquez ◽

...

Keyword(s):

Functional Imaging ◽

Fdg Pet ◽

Imaging Techniques ◽

Extracellular Volume ◽

Tumour Response ◽

Dce Mri ◽

Pet Ct ◽

Hypoxia Marker ◽

18F Fdg ◽

Fdg Pet Ct

Objectives. Biologically guided radiotherapy needs an understanding of how different functional imaging techniques interact and link together. We analyse three functional imaging techniques that can be useful tools for achieving this objective.Materials and Methods. The three different imaging modalities from one selected patient are ADC maps, DCE-MRI, and 18F-FDG PET/CT, because they are widely used and give a great amount of complementary information. We show the relationship between these three datasets and evaluate them as markers for tumour response or hypoxia marker. Thus, vascularization measured using DCE-MRI parameters can determine tumour hypoxia, and ADC maps can be used for evaluating tumour response.Results. ADC and DCE-MRI include information from 18F-FDG, as glucose metabolism is associated with hypoxia and tumour cell density, although 18F-FDG includes more information about the malignancy of the tumour. The main disadvantage of ADC maps is the distortion, and we used only low distorted regions, and extracellular volume calculated from DCE-MRI can be considered equivalent to ADC in well-vascularized areas.Conclusion. A dataset for achieving the biologically guided radiotherapy must include a tumour density study and a hypoxia marker. This information can be achieved using only MRI data or only PET/CT studies or mixing both datasets.

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Effect of Exercise on Inflamed Psoas Muscle in Women with Obesity: A Pilot Prospective 18F-FDG PET/CT Study

Diagnostics ◽

10.3390/diagnostics11020164 ◽

2021 ◽

Vol 11 (2) ◽

pp. 164

Author(s):

Kisoo Pahk ◽

Eung Ju Kim ◽

Chanmin Joung ◽

Hyun Woo Kwon ◽

Hong Seog Seo ◽

...

Keyword(s):

Physical Exercise ◽

Systemic Inflammation ◽

Metabolic Activity ◽

Fdg Pet ◽

Exercise Program ◽

Psoas Muscle ◽

Increased Risk ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Obesity increases inflammation in skeletal muscle thereby promoting systemic inflammation which leads to increased risk of cardiometabolic disease. This prospective study aimed to evaluate whether the metabolic activity of psoas muscle (PM) was associated with systemic inflammation, and whether physical exercise could reduce the PM metabolic activity evaluated by 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in women with obesity. A total of 23 women with obesity who participated in a 3-month physical exercise program were enrolled. 18F-FDG PET/CT was performed before the start of the program (baseline) and after completion of the program. The maximum standardized uptake value of psoas muscle (PM SUVmax) was used for the PM metabolic activity. The SUVmax of spleen and bone marrow, and the high-sensitivity C-reactive protein were used to evaluate the systemic inflammation. At baseline, PM SUVmax was strongly correlated with the systemic inflammation. The exercise program significantly reduced the PM SUVmax, in addition to adiposity and systemic inflammation. Furthermore, we found that the association between PM SUVmax and the systemic inflammation disappeared after completion of the exercise program. In women with obesity, PM SUVmax, assessed by 18F-FDG PET/CT, was associated with obesity-induced systemic inflammation and exercise reduced the PM SUVmax and eliminated its association with systemic inflammation.

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Semi-Quantitative and Quantitative [18F]FDG-PET/CT Indices for Diagnosing Large Vessel Vasculitis: A Critical Review

Diagnostics ◽

10.3390/diagnostics11122355 ◽

2021 ◽

Vol 11 (12) ◽

pp. 2355

Author(s):

Olivier Gheysens ◽

François Jamar ◽

Andor W. J. M. Glaudemans ◽

Halil Yildiz ◽

Kornelis S. M. van der Geest

Keyword(s):

Fdg Pet ◽

Imaging Techniques ◽

Visual Assessment ◽

Large Vessel Vasculitis ◽

Large Vessel ◽

Liver Uptake ◽

Fdg Uptake ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

To confirm the diagnosis of large vessel vasculitis (LVV) with high accuracy, one of the recommended imaging techniques is [18F]Fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography ([18F]FDG-PET/CT). Visual assessment of [18F]FDG uptake in the arterial wall compared to liver uptake is the mainstay for diagnosing LVV in routine clinical practice. To date, there is no consensus on the preferred semi-quantitative or quantitative parameter for diagnosing LVV. The aim of this review is to critically update the knowledge on the available evidence of semi-quantitative and quantitative [18F]FDG uptake parameters for diagnosing LVV and to provide future directions for methodological standardization and research.

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Melanom in izolirane metastaze v vranici-prikaz primera in pregled literature

Slovenian Medical Journal ◽

10.6016/zdravvestn.1146 ◽

2015 ◽

Vol 84 (6) ◽

Author(s):

Jerica Škedelj ◽

Ivana Žagar ◽

Marko Snoj

Keyword(s):

Fdg Pet ◽

Malignant Disease ◽

Imaging Techniques ◽

Rare Event ◽

Stage Iv ◽

Pet Ct ◽

S 100 ◽

Fdg Pet Ct

Background. Metastases to the spleen are considered a rare event generally occurring during the late stage of malignant disease. Isolated metastases are even rarely described. In the past years the number of reported cases in literature has risen mainly due to the improvements of the imaging techniques and the use of FDG-PET/CT in the follow-up of the patients with malignant disease. Even though melanoma can disseminate to any organ, metastases to spleen, found during life, are rare. Moreover, proven isolated metastases in the spleen are even seldomly described. Case report. We report a case of 61-year-old man with known skin melanoma treated in our Institute from 2009. During the regular follow up raised values of S-100 marker and isolated lesions in the spleen found on FDG-PET/CT were described. Due to isolated metastatic disease, splenectomy was indicated.Conclusion. Patients with stage IV. melanoma have poor prognosis, the median survival is estimated to six months. According to studies, metastasectomies for isolated metastases in solid organs can significantly improve survival of these patients. In melanoma patients with FDG-PET/CT proven isolated metastases to the spleen, splenectomy can significantly improve their survival and quality of life.

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