Chronic Pediatric Immune Thrombocytopenia Is Not Associated With Herpes Virus Infection Status

Background: Immune thrombocytopenia (ITP) is characterized by non-chronic (transient, <12 months) and chronic (≥12 months) decline in the number of platelets. Herpes virus infections have been shown, in many studies, to be associated with the development of ITP. However, it remains unclear whether the herpes virus infection status is associated with the chronic ITP.Methods: We reviewed 480 primary pediatric patients with ITP in the period from January 2017 to December 2019. The prevalence of herpes virus antibodies including the Cytomegalovirus (CMV), Herpes simplex virus 1 (HSV-1), Herpes simplex virus 2 (HSV-2), and Epstein Barr virus were recorded. The levels of serum complement C3 and C4, T (CD3+, CD4+, CD8+), B (CD19+) lymphocytes, and natural killer (CD16+ 56+) cells were also analyzed. Multivariate analysis was used to evaluate the associations between chronic ITP and herpes virus infection status.Results: Compared with non-chronic, patients with chronic ITP had older age (≥3 years), lower levels of hemoglobin and complement C3, and lower probability of CMV and HSV-2 infections (IgM positive; p < 0.05). Patients with herpes virus infection had lower serum platelet counts (p < 0.001), lower complement C3 levels and lower CD4+/CD8+ cells ratio (p < 0.05). Furthermore, platelet counts were positively correlated with CD4+/CD8+ cells ratios (r = 0.519; p = 0.0078), and negatively correlated with T cells (CD3+: r = −0.458, p = 0.0213; CD8+: r = −0.489, p = 0.0131). Multivariate analysis showed that age (OR, 1.644; 95%CI, 1.007–2.684; p = 0.047) was an adverse risk factor for chronic ITP and CMV IgM positive (OR, 0.241; 95%CI, 0.072–0.814; p = 0.022) had lower risk of chronic ITP development, while other herpes virus infection statuses and clinical features were not.Conclusion: Although herpes virus infections were associated with the onset of ITP, our findings indicated that herpes virus infection status might not be a risk factor for chronic ITP.

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Diagnosis dan tatalaksana nyeri pada rongga mulut yang disebabkan oleh infeksi virus herpes Diagnosis and management of pain in oral cavity caused by herpes virus infection

Journal of Dentomaxillofacial Science ◽

10.15562/jdmfs.v11i1.291 ◽

2012 ◽

Vol 11 (1) ◽

pp. 33

Author(s):

Erni Marlina ◽

Ali Yusran ◽

Zohra Nazaruddin

Keyword(s):

Virus Infection ◽

Herpes Virus ◽

Virus Infections ◽

Herpes Virus Infection ◽

Varicella Zoster ◽

Barr Virus ◽

Herpes Virus Infections ◽

Epstein Barr ◽

Herpès Virus ◽

Simplex Virus

There are 80 types of known herpes virus, 8 of them can cause infection on humans. They are herpes simplex virus(HSV) 1 and 2, varicella zoster virus (VZV), cytomegalovirus, Epstein-Barr virus, human herpes virus (HHV6) Aand B, and paramyxovirus. HSV1, HSV2, and VZV are the virus known to cause oral mucosal diseases. This paperaims to review and discuss orofacial pain caused by herpes virus infection. Detail anamnesis about prodromal signand symptom with clinical features that vesicles, labial and intraoral lesions, and unilateral distribution of lesionsare characterized oral herpes virus infections. It can be concluded that detailed anamnesis and an understandingabout oral clinical sign and symptom may confirm diagnosis of herpes virus infections.

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PECULIARITIES OF EFFECTOR LYMPHOCYTES SUBPOPULATIONS IN PATIENTS WITH UVEAL MELANOMA DURING ACTIVATION AND CHRONIC PROGRESS OF HERPESVIRAL INFECTION

Russian Journal of Infection and Immunity ◽

10.15789/2220-7619-foe-1596 ◽

2021 ◽

Author(s):

N. Balatskaya ◽

S. Saakyan ◽

E. Myakoshina ◽

I. Kulikova ◽

G. Krichevskaya

Keyword(s):

Virus Infection ◽

Uveal Melanoma ◽

Chronic Infection ◽

Herpes Virus ◽

Virus Infections ◽

Herpes Virus Infection ◽

Absolute Content ◽

Herpes Virus Infections ◽

The Absolute ◽

Herpès Virus

The immune response to any antigen includes the induction of effector and regulatory T lymphocytes. In tumors, an imbalance in the subpopulation of lymphocytes is noted. Ophthalmotropic pathogens of herpes virus infections play a role in the etiopathogenesis of some oncological processes in the tissues of the eye. Their “cancer modulating” role is to regulate the functions of immunocompetent cells by viruses and reprogram it in the direction of greater progression of tumor growth. The aim of our study was a comparative analysis of the content of effector subpopulations of blood lymphocytes in patients with uveal melanoma during activation and the chronic course of herpes virus infection. The study involved 141 people: with uveal melanoma 70 patients, with corneal ulcers and involvement of the uveal tract - 38 patients and 33 healthy donors. Immunophenotyping was performed by flow laser cytofluorimetry using a monoclonal antibody system to differentiate lymphocyte subpopulations. IgM and IgG antibodies to herpes virus infections were determined in an enzyme-linked immunosorbent assay (ELISA) on an automatic ELISA analyzer "Lazurite" (USA) with diagnostic kits of CJSC Vector-Best (Koltsovo). The results of the study showed that the absolute number of blood lymphocytes (CD45 +) in patients with uveal melanoma, regardless of the presence of active or chronic herpes virus infection, did not differ from the values in healthy donors. In patients with corneal ulcers involving the uveal tract, an increase was noted. A decrease in the relative and absolute content of T cells (CD3+) was revealed in patients with uveal melanoma during activation and the chronic course of herpes virus infection. An increase in the absolute content of CD3 + was noted in patients with active and chronic herpesvirus infection in patients with inflammatory lesions of the eye. There was no difference in the relative and absolute contents of the subpopulation of CD3 + CD4 + helpers / inducers upon activation of herpes virus infections in tumor. With corneal ulcers - a significant increase in the absolute content of CD3 + CD4 + helpers / inducers with active and chronic infection. In chronic herpes virus infection, an increase in the relative and absolute number of cytotoxic T-lymphocytes (CD3 + CD8 +) with uveal melanoma was revealed. With active infection, a decrease in the relative number of T-lymphocytes (CD3 + CD8 +) in the tumor was noted. With corneal ulcers involving the uveal tract, an increase in the absolute content during activation and chronic infection and a decrease in the relative content compared to the norm were determined. When analyzing the “double positive” T cells in a tumor, an increase in relative and absolute indices was observed in chronic and active infection with herpes viruses. The same trends were observed with inflammatory eye diseases. Analysis of the content of B-lymphocytes (CD19 +) in blood with melanoma showed an increase in the absolute number during activation and the chronic course of herpes virus infection. When analyzing the indicators of the absolute and relative content of B-lymphocytes (CD19 +) with inflammation of the membranes of the eyes, their increase was revealed regardless of activation or chronic infection. The relative number of natural killers (CD16 + CD56 +) of blood with uveal melanoma increased with infection activation. In inflammatory eye diseases, a decrease in the relative content of natural killers (CD16 + CD56 +) was found in chronic infection and active herpes virus infection. With melanoma, no changes in the index of the ratio CD4 + / CD8 + were detected, with ulcerative lesions of the cornea involving the uveal tract, its increase was noted in acute and chronic infections with herpes virus infections. (p <0.05). Thus, our own studies suggest a deep suppression of the immune system of the body of patients with uveal melanoma, which does not allow the activation of antiviral protection. Tumor causes multidirectional shifts in the relative and absolute content of lymphocytes during activation and chronic infection with herpes virus infections. The results obtained are important for the development of personalized approaches to the prognosis and treatment of patients with uveal melanoma.

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Epizootical situation on herpes virus infections, leptospirosis and gelminthosis in horses in several regions of Ukraine

Scientific Messenger of LNU of Veterinary Medicine and Biotechnology ◽

10.15421/nvlvet8337 ◽

2018 ◽

Vol 20 (83) ◽

pp. 194-199

Author(s):

O.E. Halatiuk ◽

А.A. Antoniuk ◽

O.R. Kalnaus

Keyword(s):

Virus Infection ◽

Total Protein ◽

Herpes Virus ◽

Absolute Number ◽

Precipitation Process ◽

Virus Infections ◽

Herpes Virus Infection ◽

Herpes Virus Infections ◽

The Absolute ◽

Herpès Virus

The distribution of herpes virus infections of the first and second type in tribal horses for the last five years has been established. During this period, a 1301 samples of blood serum samples of horses were investigated in the diffusion precipitation process. Out of these, 412 or 31.6% of the studied specimens were positive for the herpes virus infection of the first type, 473 or 36.4% for the second-generation herpes virus infection, and 345 or 26.5% of the animals were co-infected with herpes virus infections of the first and second type, respectively. The determination of the epizootic situation in the regions shows that the highest percentage of infections with herpes virus of the first and second types is established in Ternopil region, and the smallest in Chernivtsi. In breeding reproducers of the Chernivtsi region, the level of infection of EHV 1 and EHV 2 types does not exceed 10% of the population. We conducted a study on the coexistence of herpes virus infections, leptospirosis and helminthiasis in horses. The results of the coprological research provide an opportunity to state that in all regions the strongilidosis of horses are the most common. Also, frequent cases of infection with dictiocaulosis testify to the grazing of horses on compatible pastures with cattle. The study, based on the latent course of leptospirosis, depending on the severity of the degree of damage by strontium glands, suggests that with a consistent course of leptospirosis and strontium glands increases the number of leukocytes, eosinophils, neutrophils and total protein. In horses positive in the RMA for leptospirosis and free from strontium glands, a decrease in the number of erythrocytes, lymphocytes, eosinophils and an increase in the number of leukocytes, neutrophils and total protein is observed. In the horses positive in the RMA and affected by strontium, there is a tendency to increase the number of red blood cells, leukocytes, and eosinophils. However, it was found that with an increase in antibody titers in the RMA 1:100 and the intensity of invasion by strontials of 100 and more eggs in 1 gram of feces, a significant decrease (P < 0.001) of the absolute number of lymphocytes and a significant increase (P < 0.001) of the absolute number of eosinophils and neutrophils. A significant decrease in the absolute number of lymphocytes in horses with latent leptospirosis with antibody titres of 1:100 in the RMA and the presence of 100 and more eggs in 1 gram of feces may indicate the development of the immunodeficiency state in such animals and the desirability of immediate demyelination.

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DIAGNOSTICS OF AUDITORY FUNCTION IN PATIENTS WITH HERPES VIRUS INFECTION

Science and Innovations in Medicine ◽

10.35693/2500-1388-2018-0-1-51-54 ◽

2018 ◽

Vol 3 (1) ◽

pp. 51-54

Author(s):

H E Karabaev ◽

M T Nasretdinova

Keyword(s):

Virus Infection ◽

Herpes Virus ◽

Event Related Potentials ◽

Type I ◽

Auditory Function ◽

Herpes Virus Infection ◽

Auditory Analyzer ◽

Related Potentials ◽

Herpès Virus ◽

Simplex Virus

Aim - to increase the effectiveness of diagnosis in cases of impaired auditory function in persons with herpes virus infection. Materials and methods. Short-latent auditory event-related potentials were studied in 47 patients with auditory function impairment infected with herpes virus. Results. Contamination of the auditory analyzer with the herpes simplex virus type I is characterized by the impairment of the distal and proximal parts of the auditory nerve and cochlear nuclei, and in the presence of cytomegalovirus (both in mono-and mixed combination) the auditory analyzer is damaged at the level of the brainstem - from the upper olivar complex to the lower tubercles of the quadruple.

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Active Herpes Virus Infection in Young Children

CHILDREN INFECTIONS ◽

10.22627/2072-8107-2018-17-4-22-28 ◽

2018 ◽

Vol 17 (4) ◽

pp. 22-28 ◽

Cited By ~ 1

Author(s):

N. Yu. Egorova ◽

O. V. Molochkova ◽

L. N. Guseva ◽

N. L. Waltz ◽

K. P. Chusov

Keyword(s):

Virus Infection ◽

Young Children ◽

Infectious Mononucleosis ◽

Herpes Virus ◽

Clinical Manifestations ◽

Virus Infections ◽

Herpes Virus Infection ◽

Symptom Complex ◽

Herpès Virus ◽

Timely Administration

Under observation were 122 young children (up to 3 years of age), who were identified markers of active forms of herpes virus infections. Markers were studied by PCR in blood, smear from tonsils, saliva, cerebrospinal fluid, urine with determination DNA of HSV 1—2 type, EBV, CMV, HHV-6 type, antigens were determined by indirect immunofluorescence in blood lymphocytes, by ELISA in serum — antibodies of the classes IgM and IgG. Herpesvirus infection occurs at an early age and contributes to the formation of various infectious and somatic pathology. In children from birth to 1 year of life, CMV infection in the form of a mono-infection with symptoms of CNS damage, generalized forms, neutropenia is more common (79% of cases). In children aged 1 to 2 years, in 76% of cases, HHV-6 infection is detected, more often in mixed variants. Patients of this group are observed with a long subfebrile condition, neutropenia, infectious mononucleosis. In the third year of life, there is an increase in infection of children with EBV, with approximately the same frequency of EBV and HHV-6, most often in mixed forms, the clinical manifestations of which is a typical symptom complex of infectious mononucleosis. At this age, the active persistence of herpes viruses contributes to the formation of a group of frequently ill children. Thus, when examining young children with various pathologies, it is necessary to diagnose herpes virus infection using modern methods to detect its active forms for the timely administration of etiotropic therapy.

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Clinical manifestations of infectious mononucleosis in primary or reactivated herpes virus infection

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) ◽

10.21508/1027-4065-2020-65-1-37-44 ◽

2020 ◽

Vol 65 (1) ◽

pp. 37-44

Author(s):

O. I. Demina ◽

T. A. Chebotareva ◽

L. N. Mazankova ◽

V. B. Tetova ◽

O. N. Uchaeva

Keyword(s):

Virus Infection ◽

Infectious Mononucleosis ◽

Herpes Virus ◽

Clinical Manifestations ◽

Virus Infections ◽

Herpes Virus Infection ◽

Infectious Process ◽

Domestic Literature ◽

Herpes Virus Infections ◽

Herpès Virus

Based on the analysis of foreign and domestic literature, the article presents the features of infectious mononucleosis caused by the main pathogens from the Herpesviridae family, course of the disease at various phases of the infectious process. The article identifies clinical and laboratory manifestations characteristic of each pathogen. The authors discuss the issues related to the lack of the unified terminology for describing chronic herpes virus infection. The article discusses the causes of persistent herpes virus infections, risk factors for the adverse course and outcome of herpes virus infections.

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