Preoperative Left Ventricle End Diastolic Volume Index as a Predictor for Low Cardiac Output Syndrome After Surgical Closure of Secundum Atrial Septal Defect With Small-Sized Left Ventricle

Introduction: Low cardiac output syndrome is one of the postoperative complications that are associated with significant morbidity and mortality after surgical closure of atrial septal defect (ASD) with small-sized left ventricle (LV). This study investigated whether preoperative left ventricular end-diastolic volume index (LVEDVi) could accurately predict low cardiac output syndrome (LCOS) after surgical closure of ASD with small-sized LV.Method: This retrospective cohort study involved adult ASD patients with small-sized LV from January 2018 to December 2019 in National Cardiovascular Center Harapan Kita. Preoperative MRI data to assess the left and right ventricle volume were collected. A bivariate analysis using independent Student's t-test was done. Diagnostic test using receiver operating characteristic (ROC) curve was also done to obtain the area under the curve (AUC) value. The best cutoff point was determined by Youden's index.Result: Fifty-seven subjects were involved in this study [age (mean ± SD) 32.56 ± 13.15 years; weight (mean ± SD) 48.82 ± 12.15 kg]. Subjects who had post-operative LCOS (n = 30) have significantly lower LVEDVi (45.0 ± 7.42 ml/m2 vs. 64.15 ± 13.37 ml/m2; p < 0.001), LVEDV (64.6 ± 16.0 ml vs. 85.9 ± 20.7 ml; p < 0.001), LVSV (38.97 ± 11.5 ml vs. 53.13 ± 7.5 ml; p < 0.001), and LVSVi (27.28 ± 8.55 ml/m2 vs. 37.42 ± 5.35 ml/m2; p < 0.001) compared to subjects who did not have post-operative LCOS (n = 27). ROC analysis showed that the best AUC was found on LVEDVi (AUC 95.3%; 95% confidence interval: 90.6–100%). The best cutoff value for LVEDVi to predict the occurrence of LCOS after surgical closure of ASD was 53.3 ml/m2 with a sensitivity of 86.7% and a specificity of 85.2%.Conclusion: This study showed that preoperative LVEDVi could predict LCOS after surgical closure of ASD with small-sized LV with a well-defined cutoff. The best cutoff value of LVEDVi to predict the occurrence of LCOS after surgical ASD closure was 53.5 ml/m2.

Download Full-text

Impact of Right Ventricular Dilatation in Patients with Atrial Septal Defect

Journal of Interventional Cardiology ◽

10.1155/2020/9509105 ◽

2020 ◽

Vol 2020 ◽

pp. 1-5

Author(s):

Rie Nakayama ◽

Yoichi Takaya ◽

Teiji Akagi ◽

Koji Nakagawa ◽

Nobuhisa Watanabe ◽

...

Keyword(s):

Right Ventricular ◽

Atrial Septal Defect ◽

Exercise Capacity ◽

Septal Defect ◽

Adult Patients ◽

Volume Index ◽

End Diastolic Volume ◽

The Mean ◽

Asd Closure ◽

The Relationship

Objective. The aim of this study was to examine the relationship between right ventricular (RV) volume and exercise capacity in adult patients with atrial septal defect (ASD) and to determine the degree of RV dilatation for transcatheter ASD closure. Background. RV dilatation is an indication of transcatheter ASD closure; however, few studies have reported the clinical significance of RV dilatation. Methods. We enrolled 82 consecutive patients (mean age, 49 ± 18 years; female, 68%) who underwent cardiac magnetic resonance imaging and symptom-limited cardiopulmonary exercise test before ASD closure. The relationship between RV volume and peak oxygen uptake (VO2) was evaluated. Results. The mean RV end-diastolic volume index was 108 ± 27 ml/m2 (range, 46 to 180 ml/m2). The mean peak VO2 was 24 ± 7 ml/min/kg (range, 14 to 48 ml/min/kg), and the mean predicted peak VO2 was 90 ± 23%. There were significant negative relationships of RV end-diastolic volume index with peak VO2 (r = −0.28, p<0.01) and predicted peak VO2 (r = −0.29, p<0.01). The cutoff value of RV end-diastolic volume index <80% of predicted peak VO2 was 120 ml/m2, with the sensitivity of 49% and the specificity of 89%. Conclusions. There was a relationship between RV dilatation and exercise capacity in adult patients with ASD. RV end-diastolic volume index ≥120 ml/m2 was related to the reduction in peak VO2. This criterion of RV dilatation may be valuable for the indication of transcatheter ASD closure.

Download Full-text

Penanganan Perioperatif Pasien Dengan TOF dan Kardiomiopati Dilatatif Disertai Multiple Thrombus di Semua Ruang Jantung

JAI (Jurnal Anestesiologi Indonesia) ◽

10.14710/jai.v9i1.19819 ◽

2017 ◽

Vol 9 (1) ◽

pp. 10

Author(s):

Fajar Perdhana ◽

Prieta Adriane

Keyword(s):

Blood Pressure ◽

Cardiac Output ◽

Right Ventricle ◽

Septal Defect ◽

Outflow Tract ◽

Pericardial Patch ◽

Low Cardiac Output Syndrome ◽

Low Cardiac Output ◽

Goretex Patch

Tetrallogy of Fallot (TOF) didefinisikan sebagai kondisi penyakit jantung kongenital yang ditandai dengan adanya obstruksi right ventricle outflow tract (RVOTO) baik stenosis pada supravalvar, valvar dan subvalvar, adanya ventricle septal defect (VSD), dextroposisi dari aorta dan hipertrofi ventrikel kanan. Kondisi ini diperberat dengan kardiomiopati dilatatif yang menyebabkan pasien jatuh pada keadaan gagal jantung dan pembentukan trombus multipel di semua ruang jantung. Tantangan perioperatif adalah terjadinya tet spell pada periode pre CardioPulmonary By pass (CPB), dan depresi kontraktilitas dapat menyebabkan gagal jantung. Pasca operasi beresiko tinggi untuk terjadi low cardiac output syndrome. Anak usia 2 tahun 10 bulan dengan diagnosis TOF dan kardiomiopati dilatatif disertai pembentukan trombus multipel yang menjalani prosedur total koreksi, dengan penyulit penyerta gagal jantung yang membaik dengan terapi medikamentosa, fungsi ventrikel kiri dan ventrikel kanan yang turun. Pasien dipasang monitoring standar EKG, SpO2, dan NIBP, kemudian dilakukan induksi inhalasi dengan sevofluran, selanjutnya dilakukan pemasangan invasif blood pressure pada arteri radialis kiri dan pemasangan kateter vena sentral (CVC) pada vena jugularis kanan. Dilakukan tindakan evakuasi trombus, penutupan VSD dengan goretex patch dan reseksi infundibulum kemudian dilakukan pericardial patch untuk melebarkan Right Ventricel Outflow Tract (RVOT). Pasca operasi pasien mengalami low cardiac ouput syndrome,dirawat selama 21 hari di ICU, dan dilakukan trakeostomi pada perawatan hari ke-9. Pasien berhasil disapih dari ventilator pada perawatan hari ke-13 dan pindah dari ICU ke ruang perawatan pada hari ke-21. Prosedur total koreksi pada pasien TOF dengan disertai kardiomiopati dilatatif merupakan tantangan tersendiri bagi dokter ahli anestesi. Persiapan pre-operasi yang baik, manajemen durante operasi dan monitoring yang seksama serta perawatan pasca operasi yang berkesinambungan menghasilkan hasil yang baik.

Download Full-text

Blood gas analysis in newborns with low cardiac output syndrome after cardiac surgery.

The Bulletin of Bakoulev Center Cardiovascular Diseases ◽

10.24022/1810-0694-2018-19-5-676-687 ◽

2018 ◽

Vol 19 (5) ◽

pp. 676-687

Author(s):

G.G. Khubulava ◽

A.B. Naumov ◽

S.P. Marchenko ◽

O.Yu. Chupaeva ◽

A.A. Seliverstova ◽

...

Keyword(s):

Cardiac Output ◽

Cardiac Surgery ◽

Blood Gas Analysis ◽

Gas Analysis ◽

Blood Gas ◽

Low Cardiac Output Syndrome ◽

Low Cardiac Output

Download Full-text

Dobutamine-sparing versus dobutamine-to-all strategy in cardiac surgery: a randomized noninferiority trial

Annals of Intensive Care ◽

10.1186/s13613-021-00808-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Rafael Alves Franco ◽

Juliano Pinheiro de Almeida ◽

Giovanni Landoni ◽

Thomas W. L. Scheeren ◽

Filomena Regina Barbosa Gomes Galas ◽

...

Keyword(s):

Cardiac Output ◽

Cardiac Surgery ◽

Prolonged Mechanical Ventilation ◽

Kidney Injury ◽

Composite Endpoint ◽

Tissue Perfusion ◽

Hospital Length Of Stay ◽

Low Cardiac Output Syndrome ◽

Low Cardiac Output ◽

Noninferiority Trial

Abstract Background The detrimental effects of inotropes are well-known, and in many fields they are only used within a goal-directed therapy approach. Nevertheless, standard management in many centers includes administering inotropes to all patients undergoing cardiac surgery to prevent low cardiac output syndrome and its implications. Randomized evidence in favor of a patient-tailored, inotrope-sparing approach is still lacking. We designed a randomized controlled noninferiority trial in patients undergoing cardiac surgery with normal ejection fraction to assess whether an dobutamine-sparing strategy (in which the use of dobutamine was guided by hemodynamic evidence of low cardiac output associated with signs of inadequate tissue perfusion) was noninferior to an inotrope-to-all strategy (in which all patients received dobutamine). Results A total of 160 patients were randomized to the dobutamine-sparing strategy (80 patients) or to the dobutamine-to-all approach (80 patients). The primary composite endpoint of 30-day mortality or occurrence of major cardiovascular complications (arrhythmias, acute myocardial infarction, low cardiac output syndrome and stroke or transient ischemic attack) occurred in 25/80 (31%) patients of the dobutamine-sparing group (p = 0.74) and 27/80 (34%) of the dobutamine-to-all group. There were no significant differences between groups regarding the incidence of acute kidney injury, prolonged mechanical ventilation, intensive care unit or hospital length of stay. Discussion Although it is common practice in many centers to administer inotropes to all patients undergoing cardiac surgery, a dobutamine-sparing strategy did not result in an increase of mortality or occurrence of major cardiovascular events when compared to a dobutamine-to-all strategy. Further research is needed to assess if reducing the administration of inotropes can improve outcomes in cardiac surgery. Trial registration ClinicalTrials.gov, NCT02361801. Registered Feb 2nd, 2015. https://clinicaltrials.gov/ct2/show/NCT02361801

Download Full-text