scholarly journals Polydeoxyribonucleotide, an Adenosine-A2A Receptor Agonist, Preserves Blood Testis Barrier from Cadmium-Induced Injury

2017 ◽  
Vol 07 ◽  
Author(s):  
Francesco Squadrito ◽  
Antonio Micali ◽  
Mariagrazia Rinaldi ◽  
Natasha Irrera ◽  
Herbert Marini ◽  
...  
2019 ◽  
Vol 4 (2) ◽  
pp. 1-10 ◽  
Author(s):  
Anna Dons-Jensen ◽  
Line Petersen ◽  
Hans-Erik Bøtker ◽  
Toke Bek

Background: The neurotransmitter adenosine has been proposed to be involved in the pathogenesis of diabetic retinopathy, which may be due to the vasoactive properties of the compound. Previous studies have shown that adenosine can affect the tone of retinal arterioles in vitro to induce dilatation mediated by A2A and A2Breceptors and constriction mediated by A1 and A3 receptors. Purpose: To investigate effects of intravenous administration of the adenosine A2A receptor agonist regadenoson on the diameter of retinal vessels in vivo. Method: The diameter responses of larger retinal arterioles and venules were evaluated using the dynamic vessel analyser in 20 normal persons (age 22–31 years) after intravenous administration of the adenosine A2A receptor agonist regadenoson during exposure to systemic normoxia and hypoxia. Results: The diameter of retinal arterioles and venules increased significantly during stimulation with flickering light (p < 0.0001). Regadenoson reduced the flicker-induced dilatation of venules during normoxia (p = 0.0006), but otherwise had no effect on vessel diameters (p > 0.08 for all comparisons). Conclusions:Intravenous administration of the adenosine A2A receptor agonist regadenoson had no significant effect on the diameter of retinal arterioles. Future studies should investigate differential effects of intra- and extravascular administration of adenosine receptor agonists on retinal vessels.


2002 ◽  
Vol 438 (3) ◽  
pp. 183-188 ◽  
Author(s):  
John R Fozard ◽  
Karen M Ellis ◽  
Maria F Villela Dantas ◽  
Bruno Tigani ◽  
Lazzaro Mazzoni

2012 ◽  
Vol 28 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Fatemeh Kermanian ◽  
Mansooreh Soleimani ◽  
Alireza Ebrahimzadeh ◽  
Hossein Haghir ◽  
Mehdi Mehdizadeh

ChemInform ◽  
2010 ◽  
Vol 31 (10) ◽  
pp. no-no
Author(s):  
David R. Borcherding ◽  
Nelsen L. Lentz ◽  
Philip M. Weintraub ◽  
Mark W. Dudley ◽  
Roberta Secrest ◽  
...  

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0195047 ◽  
Author(s):  
Allan K. Alencar ◽  
Fábio I. Carvalho ◽  
Ananssa M. Silva ◽  
Sabrina T. Martinez ◽  
Jorge A. Calasans-Maia ◽  
...  

2007 ◽  
Vol 99 (11) ◽  
pp. 1507-1512 ◽  
Author(s):  
John McB. Hodgson ◽  
Nabil Dib ◽  
Morton J. Kern ◽  
Richard G. Bach ◽  
Richard J. Barrett

2015 ◽  
Vol 99 (12) ◽  
pp. 2494-2503 ◽  
Author(s):  
Matthew L. Stone ◽  
Ashish K. Sharma ◽  
Valeria R. Mas ◽  
Ricardo C. Gehrau ◽  
Daniel P. Mulloy ◽  
...  

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