scholarly journals Commentary: Pathophysiological Role of Histamine H4 Receptor in Cancer: Therapeutic Implications

2020 ◽  
Vol 11 ◽  
Author(s):  
Abdelhakim Salem ◽  
Tuula Salo
Keyword(s):  
Histamine H4 Receptor ◽  
Therapeutic Implications ◽  
Pathophysiological Role ◽  
H4 Receptor

scholarly journals The endocannabinoid system in modulating fear, anxiety, and stress

2020 ◽  
Vol 22 (3) ◽  
pp. 229-239
Keyword(s):  
Emotional Disorders ◽  
Stress Responses ◽  
Emotional Responses ◽  
Endocannabinoid System ◽  
Brain Structures ◽  
Therapeutic Implications ◽  
Cortical Areas ◽  
Prefrontal Cortical ◽  
Pathophysiological Role

The endocannabinoid system is widely expressed in the limbic system, prefrontal cortical areas, and brain structures regulating neuroendocrine stress responses, which explains the key role of this system in the control of emotions. In this review, we update recent advances on the function of the endocannabinoid system in determining the value of fear-evoking stimuli and promoting appropriate behavioral responses for stress resilience. We also review the alterations in the activity of the endocannabinoid system during fear, stress, and anxiety, and the pathophysiological role of each component of this system in the control of these protective emotional responses that also trigger pathological emotional disorders. In spite of all the evidence, we have not yet taken advantage of the therapeutic implications of this important role of the endocannabinoid system, and possible future strategies to improve the treatment of these emotional disorders are discussed.

scholarly journals Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications

2015 ◽  
Vol 36 (38) ◽  
pp. 2555-2564 ◽  
Author(s):  
Thomas Münzel ◽  
Tommaso Gori ◽  
John F. Keaney ◽  
Christoph Maack ◽  
Andreas Daiber
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Diastolic Heart Failure ◽  
Therapeutic Implications ◽  
Pathophysiological Role

The Critical Role of Histamine H4 Receptor in the Development of Allergic Rhinitis in Mice

2009 ◽  
Vol 123 (2) ◽  
pp. S56-S56
Author(s):  
Y. Shiraishi ◽  
K. Takeda ◽  
R.L. Thurmond ◽  
E.W. Gelfand
Keyword(s):  
Allergic Rhinitis ◽  
Critical Role ◽  
Histamine H4 Receptor ◽  
H4 Receptor
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