scholarly journals Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner

2021 ◽  
Vol 11 ◽  
Author(s):  
Margaret A. Mouat ◽  
Kristy L. Jackson ◽  
James L. J. Coleman ◽  
Madeleine R. Paterson ◽  
Robert M. Graham ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Spectral Analysis ◽  
G Protein ◽  
Cardiovascular Reactivity ◽  
Power Spectral Analysis ◽  
Vasomotor Tone ◽  
Ganglionic Blockade ◽  
Power Spectral ◽  
G Protein Coupled

GPR37L1 is a family A orphan G protein-coupled receptor (GPCR) with a putative role in blood pressure regulation and cardioprotection. In mice, genetic ablation of Gpr37l1 causes sex-dependent effects; female mice lacking Gpr37l1 (GPR37L1−/−) have a modest but significant elevation in blood pressure, while male GPR37L1−/− mice are more susceptible to cardiovascular dysfunction following angiotensin II-induced hypertension. Given that this receptor is highly expressed in the brain, we hypothesize that the cardiovascular phenotype of GPR37L1−/− mice is due to changes in autonomic regulation of blood pressure and heart rate. To investigate this, radiotelemetry was employed to characterize baseline cardiovascular variables in GPR37L1−/− mice of both sexes compared to wildtype controls, followed by power spectral analysis to quantify short-term fluctuations in blood pressure and heart rate attributable to alterations in autonomic homeostatic mechanisms. Additionally, pharmacological ganglionic blockade was performed to determine vasomotor tone, and environmental stress tests were used to assess whether cardiovascular reactivity was altered in GPR37L1−/− mice. We observed that mean arterial pressure was significantly lower in female GPR37L1−/− mice compared to wildtype counterparts, but was unchanged in male GPR37L1−/− mice. GPR37L1−/− genotype had a statistically significant positive chronotropic effect on heart rate across both sexes when analyzed by two-way ANOVA. Power spectral analysis of these data revealed a reduction in power in the heart rate spectrum between 0.5 and 3 Hz in female GPR37L1−/− mice during the diurnal active period, which indicates that GPR37L1−/− mice may have impaired cardiac vagal drive. GPR37L1−/− mice of both sexes also exhibited attenuated depressor responses to ganglionic blockade with pentolinium, indicating that GPR37L1 is involved in maintaining sympathetic vasomotor tone. Interestingly, when these mice were subjected to aversive and appetitive behavioral stressors, the female GPR37L1−/− mice exhibited an attenuation of cardiovascular reactivity to aversive, but not appetitive, environmental stimuli. Together, these results suggest that loss of GPR37L1 affects autonomic maintenance of blood pressure, giving rise to sex-specific cardiovascular changes in GPR37L1−/− mice.

Power spectral analysis of heart rate and blood pressure variability in anaesthetized dogs

1992 ◽  
Vol 146 (2) ◽  
pp. 155-164 ◽  
Author(s):  
A. E. HEDMAN ◽  
J. E. K. HARTIKAINEN ◽  
K. U. O. TAHVANAINEN ◽  
M. O. K. HAKUMÄKI
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Spectral Analysis ◽  
Blood Pressure Variability ◽  
Power Spectral Analysis ◽  
Power Spectral

scholarly journals Power Spectral Analysis of Spontaneous Blood Pressure and Heart Rate Variability in Elderly Hypertensives.

1996 ◽  
Vol 19 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Tadashi Aono ◽  
Takayuki Sato ◽  
Masanori Nishinaga ◽  
Akiko Kawamoto ◽  
Toshio Ozawa
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Spectral Analysis ◽  
Power Spectral Analysis ◽  
Power Spectral ◽  
Elderly Hypertensives

Abnormal passive head-up tilt test in subjects with symptoms of anxiety power spectral analysis study of heart rate and blood pressure

1997 ◽  
Vol 60 (2) ◽  
pp. 121-131 ◽  
Author(s):  
Gianfranco Piccirillo ◽  
Santagada Elvira ◽  
Carmela Bucca ◽  
Emanuela Viola ◽  
Mauro Cacciafesta ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Spectral Analysis ◽  
Power Spectral Analysis ◽  
Tilt Test ◽  
Analysis Study ◽  
Power Spectral ◽  
Head Up Tilt ◽  
Head Up Tilt Test

Power Spectral Analysis of Heart Rate and Diastolic Blood Pressure Variability in Migraine with and Without Aura

Cephalalgia ◽  
1997 ◽  
Vol 17 (7) ◽  
pp. 756-760 ◽  
Author(s):  
G Pierangeli ◽  
P Parchi ◽  
G Barletta ◽  
M Chiogna ◽  
E Lugaresi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Spectral Analysis ◽  
Diastolic Blood Pressure ◽  
Blood Pressure Variability ◽  
Power Spectral Analysis ◽  
Cardiovascular Responses ◽  
Valsalva Manoeuvre ◽  
Cardiovascular Reflexes ◽  
Power Spectral

Autonomic function in migraineurs during headache-free periods was studied by means of cardiovascular reflexes and power spectral analysis of heart rate and diastolic blood pressure variability. We examined 56 patients: 37 suffering from migraine without aura and 19 from migraine with aura. Cardiovascular responses to the tilt test and Valsalva manoeuvre showed a normal function of the overall baroreceptor reflex arc. Normal heart rate responses to valsalva manoeuvre and deep breathing suggested an intact parasympathetic function. Power spectral analysis of both heart rate and diastolic blood pressure variability in basal conditions and during orthostatic test showed similar sympathovagal interactions modulating cardiovascular control in migraine patients and in controls.

Power spectral analysis for autonomic influences in heart rate and blood pressure variability in fetal lambs

1996 ◽  
Vol 271 (4) ◽  
pp. H1333-H1339 ◽  
Author(s):  
Y. Kimura ◽  
K. Okamura ◽  
T. Watanabe ◽  
J. Murotsuki ◽  
T. Suzuki ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Spectral Analysis ◽  
Power Spectrum ◽  
Blood Pressure Variability ◽  
Power Spectral Analysis ◽  
Sympathetic Blockade ◽  
Arterial Blood ◽  
Power Spectral ◽  
Frequency Components

Variability of R-R intervals and arterial blood pressure signals in chronically instrumented fetal lambs was analyzed by power spectral analysis based on an assumption of maximum entropy. There were four consistent components, very low (VL, 0.01-0.025 cycle/beat), low (L, 0.025-0.125 cycle/beat), middle (M, 0.125-0.2 cycle/beat), and high (H, 0.2-0.5 cycle/beat), in the normal heart rate variability and blood pressure spectra. Integrated peaks in the power spectrum were compared before and after the administration of sympathetic and parasympathetic blockades. beta-Sympathetic blockade reduced the spectral power in the VL and L frequency components. alpha-Sympathetic blockade reduced only the M frequency component in the spectrum of R-R interval variability. Parasympathetic blockade reduced the H and L frequency components in the R-R interval variability spectrum but increased these components in the systolic blood pressure variability spectrum. The results clearly demonstrate the association between fetal autonomic activity and change of power spectrum of heart rate and blood pressure variability.

Power spectral analysis of heart rate and arterial blood pressure oscillation in brain-dead patients

1993 ◽  
Vol 44 (2-3) ◽  
pp. 101-107 ◽  
Author(s):  
Yoshihito Kita ◽  
Jun Ishise ◽  
Yutaka Yoshita ◽  
Yoshiki Aizawa ◽  
Hiroyuki Yoshio ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Spectral Analysis ◽  
Arterial Blood Pressure ◽  
Power Spectral Analysis ◽  
Pressure Oscillation ◽  
Arterial Blood ◽  
Power Spectral ◽  
Brain Dead

Impact of Changes in Respiratory Frequency and Posture on Power Spectral Analysis of Heart Rate and Systolic Blood Pressure Variability in Normal Subjects and Patients with Heart Failure

1996 ◽  
Vol 91 (1) ◽  
pp. 35-43 ◽  
Author(s):  
John E. Sanderson ◽  
Leata Y. C. Yeung ◽  
Dickens T. K. Yeung ◽  
Richard L. C. Kay ◽  
Brian Tomlinson ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Heart Rate ◽  
Spectral Analysis ◽  
High Frequency ◽  
Low Frequency ◽  
Power Spectral Analysis ◽  
Normal Subjects ◽  
Power Spectral ◽  
Patients With Heart Failure

1. Autonomic dysfunction is a major feature of congestive cardiac failure and may have an important role in determining progression and prognosis. The low-frequency/high-frequency ratio derived from power spectral analysis of heart rate variability has been proposed as a non-invasive method to assess sympatho-vagal balance. However, the effects of different respiratory rates or posture are rarely accounted for, but may be relevant in patients with heart failure in whom clinical improvement is accompanied by a fall in respiratory rate and an increased proportion of the day in the upright position. 2. We have assessed the effect of controlled respiration at different rates (10, 15, 20 breaths/min or 0.17, 0.25 and 0.33 Hz), while supine and standing, on power spectral analysis of heart rate and blood pressure variability in 11 patients with heart failure and 10 normal subjects. 3. Heart rate variance and low-frequency power (normalized units) were reduced in patients with heart failure (absent in six). During controlled breathing while supine, the power of the high-frequency component was significantly greater at 10 breaths/min than at 20 breaths/min in patients with heart failure, whether expressed in absolute units (P = 0.005) or percentage of total power (P = 0.03). 4. On standing, controlled breathing in patients with heart failure produced less change in high-frequency power (P = 0.054), but the low-frequency/high-frequency ratio at lower respiratory rates was reduced (P = 0.05). In normal subjects, as expected, respiratory rate had a highly significant effect on high-frequency power. Also, in normal subjects there was the expected increase in heart rate low-frequency power (P = 0.04) moving from supine to standing with an increase in the low-frequency/high-frequency ratio (P = 0.003), while in the patients with heart failure this was absent, reflecting blunted cardiovascular reflexes. 5. Systolic blood pressure low- and high-frequency components and their ratio were significantly affected by respiration (P > 0.03) and change in posture (P > 0.03) in both patients with heart failure and normal subjects, with a significant increase in the low-frequency/high-frequency ratio (P = 0.03) on standing in patients with heart failure, indicating that autonomic modulation of blood pressure is still operating in heart failure. 6. Thus, respiratory rate and changes in posture have a significant effect on measurements derived from spectral analysis of heart rate and blood pressure variability. Studies that use power spectral analysis as a measure of sympatho-vagal balance should control for these variables.

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