Different Members of the Fibroblast Growth Factor Receptor Family Are Specific to Distinct Cell Types in the Developing Chicken Embryo

1993 ◽  
Vol 155 (1) ◽  
pp. 107-123 ◽  
Author(s):  
Gail Patstone ◽  
Elena B. Pasquale ◽  
Pamela A. Maher
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Chicken Embryo ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Cell Types ◽  
Fibroblast Growth ◽  
Distinct Cell ◽  
Receptor Family

scholarly journals Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer

2021 ◽  
Vol 12 ◽  
Author(s):  
Yanan Liu ◽  
Canwei Wang ◽  
Jifa Li ◽  
Jiandong Zhu ◽  
Chengguang Zhao ◽  
...  
Keyword(s):  
Growth Factor ◽  
Ligand Binding ◽  
Fibroblast Growth Factor ◽  
Small Molecule ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Cancer Development ◽  
Tyrosine Kinase Receptor ◽  
Fibroblast Growth ◽  
Receptor Family

Fibroblast growth factor receptor 4 (FGFR4) is a tyrosine kinase receptor that is a member of the fibroblast growth factor receptor family and is stimulated by highly regulated ligand binding. Excessive expression of the receptor and its ligand, especially FGF19, occurs in many types of cancer. Abnormal FGFR4 production explains these cancer formations, and therefore, this receptor has emerged as a potential target for inhibiting cancer development. This review discusses the diverse mechanisms of oncogenic activation of FGFR4 and highlights some currently available inhibitors targeting FGFR4.

scholarly journals Subcellular localization of fibroblast growth factor receptor type 2 and correlation with CTNNB1 genotype in adrenocortical carcinoma

2020 ◽  
Author(s):  
Matthias Haase ◽  
Anne Thiel ◽  
Ute I. Scholl ◽  
Hany Ashmawy ◽  
Matthias Schott ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Adrenocortical Carcinoma ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Cell Types ◽  
Beta Catenin ◽  
Fibroblast Growth ◽  
Mutational Status ◽  
Cancer Types

Abstract Objective: Fibroblast growth factor receptor (FGFR) 2 regulates the development of the adrenal gland in mice. In addition, FGFR2-mediated signalling has been shown to prevent apoptosis and to enhance proliferation in adrenocortical precursor cells. The activation of the Wingless/Int-1 (WNT) / beta catenin pathway as a key mechanism of adrenocortical tumourigenesis has been linked to FGFR2 signalling in other cell types. Therefore we hypothesised that FGFR2 expression may also play a role in adrenocortical carcinoma (ACC). We conducted a pilot study and analysed protein expression of FGFR2 in 26 ACCs using immunohistochemistry technique. Data on the CTNNB1 mutation status and clinical data were correlated to the expression of FGFR2. Results: We observed a high variability in FGFR2 expression between the different tumour samples. There was a subset of ACC with comparatively high nuclear expression of FGFR2. We did not find a clear association between the CTNNB1 mutational status or clinical features and the FGFR2 expression. We conclude that FGFR signalling plays a role in adrenocortical carcinoma. Our data encourages further investigations of FGFR signalling in ACC, especially since new inhibitors of FGFR signalling are already entering clinical trials for the treatment of other cancer types.

scholarly journals Subcellular localization of fibroblast growth factor receptor type 2 and correlation with CTNNB1 genotype in adrenocortical carcinoma

2020 ◽  
Author(s):  
Matthias Haase ◽  
Anne Thiel ◽  
Ute I. Scholl ◽  
Hany Ashmawy ◽  
Matthias Schott ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Adrenocortical Carcinoma ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Cell Types ◽  
Beta Catenin ◽  
Fibroblast Growth ◽  
Mutational Status ◽  
Cancer Types

Abstract Objective: Fibroblast growth factor receptor (FGFR)2 regulates the development of the adrenal gland in mice. In addition, FGFR2-mediated signalling has been shown to prevent apoptosis and to enhance proliferation in adrenocortical precursor cells. The activation of the Wingless/Int-1 (WNT) / beta catenin pathway as a key mechanism of adrenocortical tumourigenesis has been linked to FGFR2 signalling in other cell types. Therefore we hypothesised that FGFR2 expression may also play a role in adrenocortical carcinoma (ACC). We conducted a pilot study and analysed protein expression of FGFR2 in 26 ACCs using immunohistochemistry technique. Data on the CTNNB1 mutation status and clinical data were correlated to the expression of FGFR2. Results: We observed a high variability in FGFR2 expression between the different tumour samples. There was a subset of ACC with comparatively high nuclear expression of FGFR2. We did not find a clear association between the CTNNB1 mutational status or clinical features and the FGFR2 expression. We conclude that FGFR signalling plays a role in adrenocortical carcinoma. Our data encourages further investigations of FGFR signalling in ACC, especially since new inhibitors of FGFR signalling are already entering clinical trials for the treatment of other cancer types.

scholarly journals Mannose Phosphate Isomerase Regulates Fibroblast Growth Factor Receptor Family Signaling and Glioma Radiosensitivity

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e110345 ◽  
Author(s):  
Aurélie Cazet ◽  
Jonathan Charest ◽  
Daniel C. Bennett ◽  
Cecilia Lopez Sambrooks ◽  
Joseph N. Contessa
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Receptor Family
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