scholarly journals Prognostic Value of Inflammatory Indicators in Chronic Hepatitis B Patients With Significant Liver Fibrosis: A Multicenter Study in China

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiujuan Zhang ◽  
Yusheng Jie ◽  
Zemin Wan ◽  
Shanshan Lin ◽  
Yingxian Li ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Excellent Performance ◽  
Internal Validation ◽  
Time Activity ◽  
Significant Fibrosis ◽  
Independent Validation ◽  
Significant Liver Fibrosis

Diagnosis of significant liver fibrosis is essential to facilitate the optimal treatment decisions and improve prognosis in patients with chronic hepatitis B (CHB). We aimed to evaluate the value of inflammatory indicators and construct a nomogram that effectively predicts significant liver fibrosis among CHB patients. 563 CHB patients from two centers in China from 2014 to 2019 were divided into three cohorts (development, internal validation, and independent validation cohorts), assigned into cases with significant fibrosis (liver fibrosis stages ≥2) and those without. Multiple biochemical and serological inflammatory indicators were investigated. Inflammatory indicators, Alanine aminotransferase (ALT) and aspartate aminotransferase (AST), were significantly associated with significant liver fibrosis in CHB patients but limited predictive performance, and then we combined them with prothrombin time activity percentage (PTA) and liver stiffness measurement (LSM) were identified by multivariate logistic regression analysis. Based on these factors, we constructed the nomogram with excellent performance. The area under the receiver operating characteristic curve (AUROC) for the nomogram in the development, internal validation, and independent validation cohorts were 0.860, 0.877, and 0.811, respectively. Our nomogram based on ALT and AST that had excellent performance in predicting significant fibrosis of CHB patients were constructed.

scholarly journals Prevalence and Determinants of Significant Liver Fibrosis by Vibration-Controlled Transient Elastography in Thai Chronic Hepatitis B Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-7
Author(s):  
Apichet Sirinawasatien ◽  
Thanaya Techasirioangkun ◽  
Siriporn Thongsri
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Transient Elastography ◽  
Male Gender ◽  
Significant Fibrosis ◽  
B Virus ◽  
Significant Liver Fibrosis

Aims. To describe the prevalence of significant liver fibrosis by ultrasound-based vibration-controlled transient elastography (VCTE; FibroScan®) and to identify the determinants of significant liver fibrosis in Thai chronic hepatitis B patients. Methods. A cross-sectional study of consecutive chronic hepatitis B patients performed VCTE and followed up at Rajavithi Hospital, Bangkok, Thailand, was conducted between 1 January, 2013, and 31 December, 2016. Liver fibrosis was defined as minimal (METAVIR F0-1) by VCTE < 7.2 kPa and significant (METAVIR F2-4) by VCTE ≥ 7.2 kPa. VCTE assessments and medical records were retrospectively reviewed. The prevalence and determinants of significant liver fibrosis were analyzed. Results. A total of 206 eligible patients were included; 120 patients (58.3%) were female. The mean age was 50 years (SD 12.4 years), and 32.5% had a body mass index ≥ 25. The prevalences of minimal (F 0-1) and significant fibrosis (F2-4) were 74.3% and 25.7%, respectively. The prevalence of hepatitis B e antigen negative (HBeAg -ve) was 83%. The median serum hepatitis B virus viral load was 4,340 IU/mL (range 20-271,883,036). Significant determinants of significant fibrosis (F2-4) were male gender (aOR 3.24 [95%CI: 1.36-7.72]) and high aspartate transaminase (AST) level (aOR 5.71 [95%CI: 2.03-16.04]). Conclusion. Around one-quarter of the Thai patients with chronic viral hepatitis B had significant liver disease defined by VCTE, requiring further evaluation for specific treatment for hepatitis B virus. Determinants of significant liver fibrosis were male gender and high AST level.

High prevalence of significant liver fibrosis and cirrhosis in chronic hepatitis B patients with normal ALT in central Europe

2011 ◽  
Vol 83 (6) ◽  
pp. 968-973 ◽  
Author(s):  
Thomas Göbel ◽  
Andreas Erhardt ◽  
Mathias Herwig ◽  
Christopher Poremba ◽  
Stephan Ernst Baldus ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Central Europe ◽  
High Prevalence ◽  
Normal Alt ◽  
Significant Liver Fibrosis

P.1.95: DUAL CUT-OFF ELASTOGRAPHY TO ASSESS LIVER FIBROSIS IN CHRONIC HEPATITIS B: A COHORT STUDY WITH INTERNAL VALIDATION

2011 ◽  
Vol 43 ◽  
pp. S179
Author(s):  
M. Viganò ◽  
S. Massironi ◽  
P. Lampertico ◽  
S. Paggi ◽  
M. Fraquelli ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Cohort Study ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Internal Validation

scholarly journals A New Model Using Routinely Available Clinical Parameters to Predict Significant Liver Fibrosis in Chronic Hepatitis B

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e23077 ◽  
Author(s):  
Wai-Kay Seto ◽  
Chun-Fan Lee ◽  
Ching-Lung Lai ◽  
Philip P. C. Ip ◽  
Daniel Yee-Tak Fong ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Clinical Parameters ◽  
New Model ◽  
Significant Liver Fibrosis

scholarly journals Biological Profile of Chronic Hepatitis B and its Predictive Factors According to Liver Histological Activity at the Renaissance Hospital, N’Djamena, Chad

2021 ◽  
Author(s):  
Mahamat-Saleh Tahir ◽  
Bolti Mahamat Ali ◽  
Stanislas Adjeka Doffou ◽  
Constant Assi
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Chronic Infection ◽  
Biological Profile ◽  
Hepatitis D ◽  
Positive Chronic Hepatitis ◽  
Significant Liver Fibrosis ◽  
Negative Chronic Hepatitis

Abstract Background: No study in black Africa has investigated the profile of chronic hepatitis B according to the new European association for the study of the liver (EASL) classification. The aim of the study was to determine the biological profile of chronic HBsAg carriers according to the EASL classification of chronic hepatitis B. Method: This is a prospective cross-sectional study carried out in the gastroenterology outpatient department at the Renaissance Hospital in N’Djamena from January, 2018 to July, 2019. All patients with chronic HBsAg were included and documented for at least one year. Patients with hepatitis C, hepatitis D or HIV or alcoholic were excluded. The biological profile was determined according the EASL classification: HBeAg-positive chronic infection, HBeAg-positive chronic hepatitis, HBeAg-negative chronic infection, HBeAg-negative chronic hepatitis and HBsAg-negative phase. Factors associated with presence of significant liver fibrosis were founded by logistical regression. Results: 106 patients were included. The average age were 42.4 years old. The sex ratio was 1.43. The median of the transaminase were 24 IU/ml (AST) and 21 IU/ml (ALT). 61 patients had HBeAg-negative chronic infection (59.8%) and 37 patients had HBeAg-negative chronic hepatitis (36.2%). HBeAg-positive chronic infection and HBeAg-positive chronic hepatitis were both seen in 2% of the cases. Significant liver fibrosis was independently associated with the ALT levels (Odds ratio=1.038 [1.009-1.068]; p=0.009). Conclusion: Chronic HBeAg-negative B infection is the main form in chronic HBsAg-positive carriers. Transaminases are a predictive factor for the presence of hepatic fibrosis.

scholarly journals Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B

2015 ◽  
Vol 56 (3) ◽  
pp. 272-279 ◽  
Author(s):  
Xianghua Zeng ◽  
Cheng Xu ◽  
Dengming He ◽  
Maoshi Li ◽  
Huiyan Zhang ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Significant Liver Fibrosis
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