scholarly journals Reynoutrin Improves Ischemic Heart Failure in Rats Via Targeting S100A1

2021 ◽  
Vol 12 ◽  
Author(s):  
Wenkai Yang ◽  
Hanjian Tu ◽  
Kai Tang ◽  
Haozhong Huang ◽  
Shi Ou ◽  
...  

This study investigated the effects of reynoutrin on the improvement of ischemic heart failure (IHF) and its possible mechanism in rats. The rat heart failure model was established by permanently ligating the left anterior descending coronary artery (LAD) and administering different doses of reynoutrin. Cardiac function, inflammatory factors releasing, oxidative stress, cardiomyocytes apoptosis, and myocardial fibrosis were evaluated. Western blotting was used to determine protein expression levels of S100 calcium-binding protein A1 (S100A1), matrix metallopeptidase 2(MMP2), MMP9, phosphorylated (p-) p65, and transforming growth factor -β1 (TGF-β1) in myocardial tissue of the left ventricle. Results showed that reynoutrin significantly improved cardiac function, suppressed the release of inflammatory factors, reduced oxidative stress, inhibited cardiomyocytes apoptosis, and attenuated myocardial fibrosis in rats with IHF. In rat myocardial tissue, permanent LAD-ligation resulted in a significant down-regulation in S100A1 expression, whereas reynoutrin significantly up-regulated S100A1 protein expression while down-regulating MMP2, MMP9, p-p65, and TGF-β1 expressions. However, when S100A1 was knocked down in myocardial tissue, the above-mentioned positive effects of reynoutrin were significantly reversed. Reynoutrin is a potential natural drug for the treatment of IHF, and its mechanism of action involves the up-regulation of S100A1 expression, thereby inhibiting expressions of MMPs and the transcriptional activity of nuclear factor kappa-B.

2015 ◽  
Vol 67 (4) ◽  
pp. 289-298 ◽  
Author(s):  
Ibrahim Elmadbouh ◽  
Magda Mansour ◽  
Mohamed Nabeh ◽  
Walaa Faried ◽  
Ahmed Abdelsabour ◽  
...  

2007 ◽  
Vol 49 (6) ◽  
pp. 416-418 ◽  
Author(s):  
Antonio Abbate ◽  
Fadi N Salloum ◽  
Ramzi A Ockaili ◽  
Alpha A Fowler ◽  
Giuseppe G L Biondi-Zoccai ◽  
...  

2020 ◽  
Vol 34 (8) ◽  
pp. 9911-9924
Author(s):  
Zoltán Szabó ◽  
Laura Vainio ◽  
Ruizhu Lin ◽  
Julia Swan ◽  
Juha J. Hulmi ◽  
...  

2007 ◽  
Vol 13 (6) ◽  
pp. S107
Author(s):  
Zsuzsanna Hollander ◽  
David Lin ◽  
Gabriela Cohen Freue ◽  
Janet Wilson-McManus ◽  
Robert Balshaw ◽  
...  

Redox Report ◽  
2014 ◽  
Vol 19 (3) ◽  
pp. 118-123 ◽  
Author(s):  
Hamit Yasar Ellidag ◽  
Esin Eren ◽  
Necat Yılmaz ◽  
Yesim Cekin

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