scholarly journals The Lactate Minimum Test: Concept, Methodological Aspects and Insights for Future Investigations in Human and Animal Models

2017 ◽  
Vol 8 ◽  
Author(s):  
Leonardo H. D. Messias ◽  
Claudio A. Gobatto ◽  
Wladimir R. Beck ◽  
Fúlvia B. Manchado-Gobatto
Keyword(s):  
Animal Models ◽  
Lactate Minimum ◽  
Methodological Aspects

scholarly journals Toward Better Reproducibility in Experimental Research on New Agents for Pulmonary Hypertension. An Analysis of Data from Four Hundred Animal Studies

2020 ◽  
Author(s):  
Magdalena Jasińska-Stroschein
Keyword(s):  
Pulmonary Hypertension ◽  
Animal Models ◽  
Animal Studies ◽  
Exercise Intolerance ◽  
Potential Drug ◽  
New Agents ◽  
Systematic Analysis ◽  
Drug Candidates ◽  
Animal Survival ◽  
Methodological Aspects

Abstract Purpose Pre-clinical data can provide a rationale for subsequent clinical trials and they are the first step in drug development; however, the therapeutic effect observed during animal studies does not necessarily translate to similar results in humans. Methods Taking the example of pulmonary hypertension, the present study explores whether the methodological aspects of preclinical experiments can determine the final result. Results The present paper describes a systematic analysis of 409 studies conducted on a variety of animal models to identify potential drug candidates for PH treatment; it explores the influence of various aspects of study design on the final outcome, e.g. type of animal model of PH, dosage schedules of tested agents, type of anesthesia, measurement of exercise intolerance or animal survival. Conclusions The animal models of PH used for pre-clinical studies are diverse and there are several methodological items within the established protocols that can determine the obtained result.

Reductionist thinking and animal models in neuropsychiatric research

2019 ◽  
Vol 42 ◽  
Author(s):  
Nicole M. Baran
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Environmental Factors ◽  
Neuropsychiatric Disorders ◽  
Model Organisms ◽  
Developmental Genetic ◽  
Term Study ◽  
Genetic And Environmental Factors ◽  
Mechanisms Of Plasticity

AbstractReductionist thinking in neuroscience is manifest in the widespread use of animal models of neuropsychiatric disorders. Broader investigations of diverse behaviors in non-model organisms and longer-term study of the mechanisms of plasticity will yield fundamental insights into the neurobiological, developmental, genetic, and environmental factors contributing to the “massively multifactorial system networks” which go awry in mental disorders.

Inflammational Animal Models for Schizophrenia

2015 ◽  
Vol 223 (3) ◽  
pp. 157-164 ◽  
Author(s):  
Georg Juckel
Keyword(s):  
Animal Model ◽  
Animal Models ◽  
Immune Activation ◽  
Microglial Activation ◽  
Treatment Options ◽  
Early Adulthood ◽  
Brain Regions ◽  
Synaptic Connections ◽  
Preventive Interventions ◽  
Immunological System

Abstract. Inflammational-immunological processes within the pathophysiology of schizophrenia seem to play an important role. Early signals of neurobiological changes in the embryonal phase of brain in later patients with schizophrenia might lead to activation of the immunological system, for example, of cytokines and microglial cells. Microglia then induces – via the neurotoxic activities of these cells as an overreaction – a rarification of synaptic connections in frontal and temporal brain regions, that is, reduction of the neuropil. Promising inflammational animal models for schizophrenia with high validity can be used today to mimic behavioral as well as neurobiological findings in patients, for example, the well-known neurochemical alterations of dopaminergic, glutamatergic, serotonergic, and other neurotransmitter systems. Also the microglial activation can be modeled well within one of this models, that is, the inflammational PolyI:C animal model of schizophrenia, showing a time peak in late adolescence/early adulthood. The exact mechanism, by which activated microglia cells then triggers further neurodegeneration, must now be investigated in broader detail. Thus, these animal models can be used to understand the pathophysiology of schizophrenia better especially concerning the interaction of immune activation, inflammation, and neurodegeneration. This could also lead to the development of anti-inflammational treatment options and of preventive interventions.

Animal models of psychopathology: The low-norepinephrine and low-serotonin rat.

1977 ◽  
Vol 32 (12) ◽  
pp. 1036-1045 ◽  
Author(s):  
Gaylord D. Ellison
Keyword(s):  
Animal Models

Sex difference in depression: Which animal models mimic it.

2020 ◽  
Vol 134 (3) ◽  
pp. 248-266
Author(s):  
Javed Iqbal ◽  
Frank Adu-Nti ◽  
Xuejiao Wang ◽  
Hui Qiao ◽  
Xin-Ming Ma
Keyword(s):  
Animal Models ◽  
Sex Difference

Animal Models in Alcohol Research-A Commentary by NIAAA Director Enoch Gordis, MD

1994 ◽  
Author(s):  
Enoch Gordis ◽  
Keyword(s):  
Animal Models

Cardiac Electrophysiological Effects of Cocaine in Animal Models

1991 ◽  
Author(s):  
Peter N. Temesy-Arnos ◽  
◽  
Theodore D. Fraker ◽  
R. Douglas Wilkerson
Keyword(s):  
Animal Models ◽  
Electrophysiological Effects

Conservation of Basic Navigation and Memory Functions Between Humans and Animal Models

2007 ◽  
Author(s):  
Celine Fouquet ◽  
Kinga Igloi ◽  
Alain Berthoz ◽  
Laure Rondi-Reig
Keyword(s):  
Animal Models ◽  
Memory Functions

Hybridizing animal models in neurobehavioral research

2008 ◽  
Author(s):  
J. L. LaPorte ◽  
A. V. Kalueff
Keyword(s):  
Animal Models

Stress protein Hsp70 as a potential anticonvulsant in animal models of epilepsy

2010 ◽  
Author(s):  
I.V. Ekimova ◽  
L.E. Nitsinskaya ◽  
Y.F. Pastukhov
Keyword(s):  
Animal Models ◽  
Stress Protein ◽  
Animal Models Of Epilepsy ◽  
Models Of Epilepsy
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