scholarly journals Sympathetic, Metabolic Adaptations, and Oxidative Stress in Autism Spectrum Disorders: How Far From Physiology?

2018 ◽  
Vol 9 ◽  
Author(s):  
Antonietta Messina ◽  
Vincenzo Monda ◽  
Francesco Sessa ◽  
Anna Valenzano ◽  
Monica Salerno ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Autism Spectrum Disorders ◽  
Autism Spectrum ◽  
Metabolic Adaptations ◽  
Spectrum Disorders ◽  
And Oxidative Stress

scholarly journals The Gut Microbiota and Oxidative Stress in Autism Spectrum Disorders (ASD)

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Tingting Hu ◽  
Yinmiao Dong ◽  
Caixia He ◽  
Mingyi Zhao ◽  
Qingnan He
Keyword(s):  
Oxidative Stress ◽  
Autism Spectrum Disorders ◽  
Neurodevelopmental Disorder ◽  
Autism Spectrum ◽  
Mucosal Barrier ◽  
Autistic Children ◽  
Early Assessment ◽  
Assessment And Treatment ◽  
Spectrum Disorders ◽  
And Oxidative Stress

Autism spectrum disorders (ASDs) are a kind of neurodevelopmental disorder with rapidly increasing morbidity. In recent years, many studies have proposed a possible link between ASD and multiple environmental as well as genetic risk factors; nevertheless, recent studies have still failed to identify the specific pathogenesis. An analysis of the literature showed that oxidative stress and redox imbalance caused by high levels of reactive oxygen species (ROS) are thought to be integral parts of ASD pathophysiology. On the one hand, this review aims to elucidate the communications between oxidative stress, as a risk factor, and ASD. As such, there is also evidence to suggest that early assessment and treatment of antioxidant status are likely to result in improved long-term prognosis by disturbing oxidative stress in the brain to avoid additional irreversible brain damage. Accordingly, we will also discuss the possibility of novel therapies regarding oxidative stress as a target according to recent literature. On the other hand, this review suggests a definite relationship between ASD and an unbalanced gastrointestinal tract (GIT) microbiota (i.e., GIT dysbiosis). A variety of studies have concluded that the intestinal microbiota influences many aspects of human health, including metabolism, the immune and nervous systems, and the mucosal barrier. Additionally, the oxidative stress and GIT dysfunction in autistic children have both been reported to be related to mitochondrial dysfunction. What is the connection between them? Moreover, specific changes in the GIT microbiota are clearly observed in most autistic children, and the related mechanisms and the connection among ASD, the GIT microbiota, and oxidative stress are also discussed, providing a theory and molecular strategies for clinical practice as well as further studies.

scholarly journals Autism Spectrum Disorders and Perinatal Complications—Is Oxidative Stress the Connection?

2019 ◽  
Vol 10 ◽  
Author(s):  
Vanja Mandic-Maravic ◽  
Marija Mitkovic-Voncina ◽  
Marija Pljesa-Ercegovac ◽  
Ana Savic-Radojevic ◽  
Miroslav Djordjevic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Autism Spectrum Disorders ◽  
Autism Spectrum ◽  
Perinatal Complications ◽  
Spectrum Disorders

scholarly journals Study of the Effect of Bisphenol A on Oxidative Stress in Children with Autism Spectrum Disorders

2017 ◽  
Vol 33 (2) ◽  
pp. 196-201 ◽  
Author(s):  
Fateheya M. Metwally ◽  
Hend Rashad ◽  
Hala M. Zeidan ◽  
Ayman Kilany ◽  
Ehab R. Abdol Raouf
Keyword(s):  
Oxidative Stress ◽  
Autism Spectrum Disorders ◽  
Bisphenol A ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorders

scholarly journals How Robust is the Evidence for a Role of Oxidative Stress in Autism Spectrum Disorders and Intellectual Disabilities?

2020 ◽  
Author(s):  
Shanna L. Burke ◽  
Jessica Cobb ◽  
Rumi Agarwal ◽  
Marlaina Maddux ◽  
Marcus S. Cooke
Keyword(s):  
Oxidative Stress ◽  
Autism Spectrum Disorders ◽  
Autism Spectrum ◽  
Careful Consideration ◽  
Sample Collection ◽  
Spectrum Disorders ◽  
Processing And Storage ◽  
And Storage ◽  
Biomarkers Of Oxidative Stress

Abstract Growing interest in the pathogenesis of autism spectrum disorders (ASDs) and other intellectual and developmental disabilities (IDD) has led to emerging evidence implicating a role for oxidative stress. However, understanding the strength of this association is made challenging by the use of a variety of purported biomarkers of oxidative stress, many of which have either uncertain specificity or flawed methods of analysis. This review aims to address this issue, which is widespread in the ASD and IDD literature, by providing readers with information concerning the strengths and limitations of the choice and analysis of biomarkers of oxidative stress. We highlight that biomarkers and assays should be specific, sensitive, reproducible, precise, robust, and chosen with careful consideration. Future studies should be sufficiently powered and address sample collection, processing, and storage which are, additionally, poorly considered, sources of bad practice, and potential errors. Only with these issues considered, will the data lead to conclusions as to the precise role of oxidative stress in ASDs and IDD.

scholarly journals Resveratrol in Autism Spectrum Disorders: Behavioral and Molecular Effects

Antioxidants ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 188 ◽  
Author(s):  
Michele Malaguarnera ◽  
Haroon Khan ◽  
Omar Cauli
Keyword(s):  
Oxidative Stress ◽  
Animal Models ◽  
Molecular Mechanisms ◽  
Autism Spectrum ◽  
Immune Alteration ◽  
Stress Markers ◽  
Behavioral Abnormalities ◽  
Spectrum Disorders ◽  
Core Symptoms ◽  
And Oxidative Stress

Resveratrol (RSV) is a polyphenolic stillbenoid with significant anti-oxidative and anti-inflammatory properties recently tested in animal models of several neurological diseases. Altered immune alteration and oxidative stress have also been found in patients with autism spectrum disorders (ASD), and these alterations could add to the pathophysiology associated with ASD. We reviewed the current evidence about the effects of RSV administration in animal models and in patients with ASD. RSV administration improves the core-symptoms (social impairment and stereotyped activity) in animal models and it also displays beneficial effects in other behavioral abnormalities such as hyperactivity, anxiety and cognitive function. The molecular mechanisms by which RSV restores or improves behavioral abnormalities in animal models encompass both normalization of central and peripheral immune alteration and oxidative stress markers and new molecular mechanisms such as expression of cortical gamma-amino butyric acid neurons, certain type of miRNAs that regulate spine growth. One randomized, placebo-controlled clinical trial (RCT) suggested that RSV add-on risperidone therapy improves comorbid hyperactivity/non-compliance, whereas no effects where seen in core symptoms of ASD No RCTs about the effect of RSV as monotherapy have been performed and the results from preclinical studies encourage its feasibility. Further clinical trials should also identify those ASD patients with immune alterations and/or with increased oxidative stress markers that would likely benefit from RSV administration.

Sign in / Sign up

Export Citation Format

Share Document