scholarly journals Disrupted Protein Expression and Altered Proteolytic Events in Hypophosphatemic Dentin Can Be Rescued by Dentin Matrix Protein 1

2020 ◽  
Vol 11 ◽  
Author(s):  
Elizabeth Guirado ◽  
Yinghua Chen ◽  
Ryan D. Ross ◽  
Youbin Zhang ◽  
Catherine Chaussain ◽  
...  

2009 ◽  
Vol 20 (5) ◽  
pp. 365-369 ◽  
Author(s):  
Elizabeth Ferreira Martinez ◽  
Luciana Alves Herdy da Silva ◽  
Cristiane Furuse ◽  
Ney Soares de Araújo ◽  
Vera Cavalcanti de Araújo

Dentin matrix protein 1 (DMP1) is an acidic phosphoprotein that plays an important role in mineralized tissue formation by initiation of nucleation and modulation of mineral phase morphology. The purpose of the present study was to examine the immunoexpression of DMP1 in tooth germs of 7 human fetuses at different gestational ages (14, 16, 19, 20, 21, 23 and 24 weeks) comparing with completed tooth formation erupted teeth. The results showed the presence of DMP1 in the dental lamina, as well as in the cells of the external epithelium, stellate reticulum and stratum intermedium of the enamel organ. However, in the internal dental epithelium, cervical loop region and dental papilla some cells have not labeled for DMP1. In the crown stage, DMP1 was expressed in the ameloblast and odontoblast layer, as well as in the dentinal tubules of coronal dentin near the odontoblast area. Erupted teeth with complete tooth formation exhibited immunolabeling for DMP1 only in the dentinal tubules mainly close to the dental pulp. No staining was observed in the enamel, predentin or dental pulp matrix. DMP1 is present in all developing dental structures (dental lamina, enamel organ, dental papilla) presenting few immunoexpression variations, with no staining in mineralized enamel and dentin.



1998 ◽  
Vol 13 (3) ◽  
pp. 422-431 ◽  
Author(s):  
Mary Macdougall ◽  
Ting Ting Gu ◽  
Xinghong Luan ◽  
Darrin Simmons ◽  
Jinkun Chen


2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Izabela Maciejewska ◽  
Kathy Svoboda ◽  
William Butler ◽  
Chunlin Qin


2002 ◽  
Vol 43 (2) ◽  
pp. 365-371 ◽  
Author(s):  
Karthikeyan Narayanan ◽  
Amsaveni Ramachandran ◽  
Jianjun Hao ◽  
Anne George


2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i505-i505
Author(s):  
Misol Lee ◽  
Changhwan Seo ◽  
Min-uk Cha ◽  
Hyoung Rae Kim ◽  
Hae-Ryong Yun ◽  
...  




1999 ◽  
Vol 40 (4) ◽  
pp. 251-258 ◽  
Author(s):  
Radhika Srinivasan ◽  
Bei Chen ◽  
Jeffrey P. Gorski ◽  
Anne George


Rheumatology ◽  
2014 ◽  
Vol 53 (12) ◽  
pp. 2280-2287 ◽  
Author(s):  
Indira Prasadam ◽  
Yinghong Zhou ◽  
Wei Shi ◽  
Ross Crawford ◽  
Yin Xiao


2001 ◽  
Vol 16 (11) ◽  
pp. 2017-2026 ◽  
Author(s):  
S. Toyosawa ◽  
S. Shintani ◽  
T. Fujiwara ◽  
T. Ooshima ◽  
A. Sato ◽  
...  


2003 ◽  
Vol 18 (8) ◽  
pp. 1506-1512 ◽  
Author(s):  
M Chaplet ◽  
L De Leval ◽  
D Waltregny ◽  
C Detry ◽  
G Fornaciari ◽  
...  


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