scholarly journals Sex- and Age-Related Physiological Profiles for Brachial, Vertebral, Carotid, and Femoral Arteries Blood Flow Velocity Parameters During Growth and Aging (4–76 Years): Comparison With Clinical Cut-Off Levels

2021 ◽  
Vol 12 ◽  
Author(s):  
Yanina Zócalo ◽  
Daniel Bia
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Physiological Age ◽  
Body Side ◽  
Age Related ◽  
Physiological Profiles ◽  
Left And Right ◽  
Expected Values ◽  
Derived Data

Ultrasound-derived blood flow velocity (BFV) levels [e.g., peak systolic velocity (PSV)], intrabeat indexes (e.g., resistive), and intersegment ratios [e.g., internal/common carotid artery (ICA/CCA) PSV ratio] are assessed to describe cardiovascular physiology and health status (e.g., disease severity evaluation and/or risk stratification). In this respect, fixed cut-off values (disregard of age or sex) have been proposed to define “significant” vascular disease from BFV-derived data (parameters). However, the use of single fixed cut-off values has limitations. Accurate use of BFV-derived parameters requires knowing their physiological age-related profiles and the expected values for a specific subject. To our knowledge, there are no studies that have characterized BFV profiles in large populations taking into account: (i) data from different age-stages (as a continuous) and transitions (childhood–adolescence–adulthood), (ii) complementary parameters, (iii) data from different arteries, and (iv) potential sex- and hemibody-related differences. Furthermore, (v) there is little information regarding normative data [reference intervals (RIs)] for BFV indexes.Aims: The aims of this study are the following: (a) to determine the need for age-, body side-, and sex-specific profiles for BFV levels and derived parameters (intrabeat indexes and intersegment ratios), and (b) to define RIs for BFV levels and parameters, obtained from CCA, ICA, external carotid, vertebral, femoral, and brachial arteries records.Methods: A total of 3,619 subjects (3–90 years) were included; 1,152 were healthy (without cardiovascular disease and atheroma plaques) and non-exposed to cardiovascular risk factors. BFV data were acquired. The agreement between left and right data was analyzed (Concordance correlation, Bland–Altman). Mean and SD equations and age-related profiles were obtained for BFV levels and parameters (regression methods; fractional polynomials).Results: Left and right body-side derived data were not always equivalent. The need for sex-specific RIs was dependent on the parameter and/or age considered. RIs were defined for each studied artery and parameter. Percentile curves were compared with recommended fixed cut-off points. The equations for sex, body-side, and age-specific BFV physiological profiles obtained in the large population (of children, adolescents, and adults) studied were included (spreadsheet formats), enabling to determine for a particular subject, the expected values and potential data deviations.

Discordant blood flow velocity waveforms in left and right brachial arteries in growth-retarded fetuses

1995 ◽  
Vol 86 (5) ◽  
pp. 734-738 ◽  
Author(s):  
W SEPULVEDA ◽  
S BOWER ◽  
P NICOLAIDIS ◽  
M DESWIET ◽  
N FISK
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Left And Right

The principle of adequate blood supply to tissues: one of postulates in the G.A. Ilizarov`s teaching

2018 ◽  
pp. 44-48
Author(s):  
В.А. Щуров
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Blood Supply ◽  
Blood Flow Velocity ◽  
Vascular System ◽  
Capillary Blood ◽  
Functional Adaptation ◽  
Capillary Blood Flow ◽  
Locomotor System ◽  
Age Related

Цель исследования - расширить существующее представление об адекватности кровоснабжения тканей: оценить соответствие количества притекающей крови энергетическим потребностям тканей, резервы функциональной адаптации сосудистого русла для функциональной устойчивости органов и возможность подстройки интенсивности метаболизма тканей под возможности системы микроциркуляции. Методика. Исследован магистральный и капиллярный кровоток (окклюзионная плетизмография, ультразвуковая допплерография, полярография, лазерная флоуметрия) у здоровых людей (157 чел.) и различных групп больных в возрасте от 5 до 70 лет (620) с травмами костей и ортопедическими заболеваниями голени в процессе лечения по Илизарову. Результаты. Обнаружено, что с увеличением возраста у здоровых и больных обследуемых снижается скорость кровотока по сосудам бедра и по средней мозговой артерии при сохранении функциональных резервов сосудистого русла, выявляемых с помощью ишемических или нагрузочных проб. Заключение. Адекватность кровоснабжения предполагает не только соответствие скорости кровотока потребностям органов, но и сохранение при этом резерва функциональной адаптации сосудистой системы, а также возрастное ограничение функциональных способностей органов движения при снижении возможностей сосудистой системы. The aim of the study was to expand the existing concept on the adequacy of blood supply as an exact correlation of the amount of delivered blood with energy demands of the tissue; to evaluate reserves of functional adaptation of the vasculature for functional stability of organs; and to assess the capability of tissue metabolism for adjusting to potentialities of the microcirculation. Methods. Conduit vessel and capillary blood flow (occlusion plethysmography, Doppler ultrasound, polarography, laser flowmetry) was studied in healthy subjects (n=157) and different groups of patients aged 5-70 years (620) with bone injuries and orthopedic diseases of the lower leg during the treatment according to Ilizarov. Results. Maximum values of blood flow in main limb arteries were not reached at maximum and average values of capillary blood flow, which were different for different groups of patients. With increasing age, the blood flow velocity in femoral blood vessels and middle cerebral artery decreased while the vasculature functional reserve was maintained as evidenced by ischemic or loading tests. Conclusion. The adequacy of blood supply involves not only matching the blood flow velocity to demands of organs but also maintaining the adaptive reserve of vasculature function as well as the age-related limitation of functional capability of the locomotor system when the vascular system function declines.

Retinal Blood Flow Velocity in Patients with Age-Related Macular Degeneration

2013 ◽  
Vol 39 (3) ◽  
pp. 304-311 ◽  
Author(s):  
Zvia Burgansky-Eliash ◽  
Hila Barash ◽  
Darin Nelson ◽  
Amiram Grinvald ◽  
Alina Sorkin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Macular Degeneration ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Age Related Macular Degeneration ◽  
Retinal Blood Flow ◽  
Age Related ◽  
Retinal Blood Flow Velocity

scholarly journals Analysis of the causes of age-related decline in the velocity of cerebral blood flow

2016 ◽  
Vol 15 (2) ◽  
pp. 45-50
Author(s):  
V. A. Schurov
Keyword(s):  
Blood Flow ◽  
Middle Cerebral Artery ◽  
Flow Velocity ◽  
Cerebral Artery ◽  
Blood Flow Velocity ◽  
Cerebral Autoregulation ◽  
Lower Limbs ◽  
Functional Test ◽  
Muscle Sample ◽  
Age Related

Goal. Determining the causes of age-related decrease of blood flow velocity (BFV) in the middle cerebral artery (MCA) in healthy subjects and in patients during surgical lengthening of stunted limbs. Methods. BFV in MCA was determined by transcranial Doppler. The analysis of the indicator in functional muscle sample of 30 healthy people 18-60 years old and 30 patients 3-62 years of lagging in the growth of one of the lower limbs in the course of its operational extension. As an indicator of cerebral autoregulation used swing changes BFV indicators during the second holding muscle functional test. Results. The age-related reduction in flow rate in the middle cerebral artery was more pronounced in patients with disorders of the musculoskeletal system. At the same time, the average value of the magnitude of blood flow velocity index changes during the functional test in healthy individuals older than 10 years, as well as in patients before treatment and during the fixation is stable (17-25 %). Conclusion. Age-related decline in the BFV at MCA is a prerequisite for the preservation of cerebral autoregulation. Disorders of cerebral autoregulation in patients undergoing distraction of limbs greatly reduces their tolerance to physical exercise.

Ocular Blood Flow Velocity in Age-related Macular Degeneration

Ophthalmology ◽  
1995 ◽  
Vol 102 (4) ◽  
pp. 640-646 ◽  
Author(s):  
Ephraim Friedman ◽  
Sara Krupsky ◽  
Anne Marie Lane ◽  
Setsuko S. Oak ◽  
Eric S. Friedman ◽  
...  
Keyword(s):  
Blood Flow ◽  
Macular Degeneration ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Ocular Blood Flow ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Tai Chi Exercise Improves Age-associated Decline in Cerebrovascular Function: A Cross-sectional Study

2020 ◽  
Author(s):  
Lili Li ◽  
Jingjing Wang ◽  
Shaoying Guo ◽  
Yangqi Xing ◽  
Xiongwen Ke ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Tai Chi ◽  
Characteristic Impedance ◽  
The Elderly ◽  
Control Group ◽  
Cerebrovascular Function ◽  
Age Related ◽  
Tai Chi Exercise

Abstract Background: Tai Chi exercise has been reported to enhance physical and mental health in the elderly; however, the mechanism remains elusive.Trial Design: We recruited 289 elderly people practicing Tai Chi for over 3 years, together with 277 age-matched old people and 102 young adults as controls. 168 Tai Chi players were successfully matched to 168 elderly controls aged 60-69 based on a propensity score for statistics.Methods: Cerebrovascular function was evaluated by measuring the hemodynamics of the carotid artery. Spearman correlation was performed to validate the age-associated physiological parameters. Results: Cerebrovascular function in the elderly significantly degenerated compared with young people, and was substantially correlated with age. Compared with the elderly control group, Tai Chi players showed significant improvements in CVHI (cerebral vascular hemodynamics indices) Score (P = 0.002), mean blood flow velocity (P = 0.014), maximal blood flow velocity (P = 0.04) and minimum blood flow velocity (P < 0.001), whereas the age-related increases in pulse wave velocity (P = 0.022), characteristic impedance (P = 0.021) and peripheral resistance (P = 0.044) were lowered. Conclusion: These data demonstrate a rejuvenation role of Tai Chi in improving the age-related decline of the cerebrovascular function.Trial registration: Chinese Clinical Trial Registry (ChiCTR1900025187).

Sign in / Sign up

Export Citation Format

Share Document