scholarly journals Three-Dimensional Evaluation on Ecotypic Diversity of Traditional Chinese Medicine: A Case Study of Artemisia annua L.

2017 ◽  
Vol 8 ◽  
Author(s):  
Lin Li ◽  
Brinckmann A. Josef ◽  
Bing Liu ◽  
Sihao Zheng ◽  
Linfang Huang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Artemisia Annua ◽  
Three Dimensional ◽  
Artemisia Annua L

scholarly journals Machine-readable Yin–Yang imbalance: traditional Chinese medicine syndrome computer modeling based on three-dimensional noninvasive cardiac electrophysiology imaging

2019 ◽  
Vol 47 (4) ◽  
pp. 1580-1591 ◽  
Author(s):  
Wei Cen ◽  
Ralph Hoppe ◽  
Aiwu Sun ◽  
Hongyan Ding ◽  
Ning Gu
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Electrical Activity ◽  
Computer Modeling ◽  
Cardiac Electrophysiology ◽  
Three Dimensional ◽  
Mathematical Physics ◽  
Syndrome Differentiation ◽  
Physics Model ◽  
Machine Readable

Objectives The principal diagnostic methods of traditional Chinese medicine (TCM) are inspection, auscultation and olfaction, inquiry, and pulse-taking. Treatment by syndrome differentiation is likely to be subjective. This study was designed to provide a basic theory for TCM diagnosis and establish an objective means of evaluating the correctness of syndrome differentiation. Methods We herein provide the basic theory of TCM syndrome computer modeling based on a noninvasive cardiac electrophysiology imaging technique. Noninvasive cardiac electrophysiology imaging records the heart’s electrical activity from hundreds of electrodes on the patient’s torso surface and therefore provides much more information than 12-lead electrocardiography. Through mathematical reconstruction algorithm calculations, the reconstructed heart model is a machine-readable description of the underlying mathematical physics model that reveals the detailed three-dimensional (3D) electrophysiological activity of the heart. Results From part of the simulation results, the imaged 3D cardiac electrical source provides dynamic information regarding the heart’s electrical activity at any given location within the 3D myocardium. Conclusions This noninvasive cardiac electrophysiology imaging method is suitable for translating TCM syndromes into a computable format of the underlying mathematical physics model to offer TCM diagnosis evidence-based standards for ensuring correct evaluation and rigorous, scientific data for demonstrating its efficacy.

scholarly journals Molecular Signatures in the Prevention of Radiation Damage by the Synergistic Effect of N-Acetyl Cysteine and Qingre Liyan Decoction, a Traditional Chinese Medicine, Using a 3-Dimensional Cell Culture Model of Oral Mucositis

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Maria P. Lambros ◽  
Lavanya Kondapalli ◽  
Cyrus Parsa ◽  
Hari Chandana Mulamalla ◽  
Robert Orlando ◽  
...  
Keyword(s):  
Dna Repair ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Three Dimensional ◽  
Human Keratinocytes ◽  
Transcriptional Level ◽  
Tissue Cultures ◽  
Primary Human Keratinocytes ◽  
Microarray Gene Expression ◽  
Acetyl Cysteine

Qingre Liyan decoction (QYD), a Traditional Chinese medicine, and N-acetyl cysteine (NAC) have been used to prevent radiation induced mucositis. This work evaluates the protective mechanisms of QYD, NAC, and their combination (NAC-QYD) at the cellular and transcriptional level. A validated organotypic model of oral mucosal consisting of a three-dimensional (3D) cell tissue-culture of primary human keratinocytes exposed to X-ray irradiation was used. Six hours after the irradiation, the tissues were evaluated by hematoxylin and eosin (H and E) and a TUNEL assay to assess histopathology and apoptosis, respectively. Total RNA was extracted and used for microarray gene expression profiling. The tissue-cultures treated with NAC-QYD preserved their integrity and showed no apoptosis. Microarray results revealed that the NAC-QYD caused the upregulation of genes encoding metallothioneins,HMOX1, and other components of the Nrf2 pathway, which protects against oxidative stress. DNA repair genes (XCP,GADD45G,RAD9, andXRCC1), protective genes (EGFRandPPARD), and genes of the NFκB pathway were upregulated. Finally, tissue-cultures treated prophylactically with NAC-QYD showed significant downregulation of apoptosis, cytokines and chemokines genes, and constrained damage-associated molecular patterns (DAMPs). NAC-QYD treatment involves the protective effect of Nrf2, NFκB, and DNA repair factors.

scholarly journals The internationalization of TCM towards Portuguese-speaking countries

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Xiaoting Zheng ◽  
Liyang Lyu ◽  
Hong Lu ◽  
Yuanjia Hu ◽  
Ging Chan
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Potential Risk ◽  
Typical Case ◽  
Regional Comparison ◽  
Regulatory Systems ◽  
Increasing Demand ◽  
Desk Review

AbstractWith the increasing demand for traditional Chinese medicine (TCM) in Portuguese-speaking countries (PSC), local regulatory systems and relevant legislation are still insufficient and lagging, even blank in some of them. This kind of unbalanced pace either makes users of TCM exposed in potential risk or eventually obstructs the long-term development of TCM in PSC. Despite existing tremendous studies on the internationalization of TCM, there are few studies specific to PSC. Thus, by a comprehensive desk review and typical case study, this article aims to summarize current situation of TCM in PSC by a cross-regional comparison, to identify various critical challenges, and further to provide an insightful reference to impel the development of TCM in PSC.

scholarly journals Stability of Alkaloids during Drying Process and Their Effect on Anticoagulating Activity of Uncariae Ramulus Cum Uncis

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Lu Zou ◽  
Fengyu Lu ◽  
Bing Lin ◽  
Ying Zhou ◽  
Tingting Liu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Constant Temperature ◽  
Herbal Medicines ◽  
Procoagulant Activity ◽  
Drying Process ◽  
Coagulation Time ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

The drying process of Uncariae Ramulus Cum Uncis (URCU), a kind of traditional Chinese medicine, was studied in a scale dryer in laboratory at 65°C. It was observed that the alkaloids content of URCU firstly showed a tendency of increasing and then decreasing after reaching the peak at the 570th minute in the process of constant temperature drying. Moreover, the coagulation time of rabbit determined by test tubes has been adopted to study the effect imposed by the content of alkaloids on the anticoagulating activity of URCU. In addition, the software of Minitab was also utilized to fit the correlation between the content of alkaloids and the anticoagulating activity of URCU. The results obtained demonstrated that anticoagulant activities were available in both rhynchophylline and isorhynchophylline, among which the latter was the stronger one, while procoagulant activity was shown in corynoxeine. The case study can provide a useful reference for the research on drying other Chinese herbal medicines (CHMs) and further study on URCU.

scholarly journals Evaluation of a multiple and global analytical indicator of batch consistency: traditional Chinese medicine injection as a case study

RSC Advances ◽  
2020 ◽  
Vol 10 (17) ◽  
pp. 10338-10351 ◽  
Author(s):  
Libing Chen ◽  
Fang Zhao ◽  
Wenzhu Li ◽  
Zeqi Chen ◽  
Jianyang Pan ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Multivariate Statistical ◽  
Statistical Tool

Evaluation of a multiple and global analytical indicator of batch consistency was employed in TCMIs with a multivariate statistical tool.

System improvement of medicine delivery service: Case study of traditional Chinese medicine

2020 ◽  
pp. 1-9 ◽  
Author(s):  
Arisara Jiamsanguanwong ◽  
Pattarapa Tientrakul ◽  
Fuanglada Sookseng ◽  
Chayapol Ophaswongse ◽  
Oran Kittithreerapronchai
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Delivery Service ◽  
System Improvement
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