Strategy of integrated evaluation on treatment of traditional Chinese medicine as ‘interaction of system to system’ and establishment of novel fuzzy target contribution recognition with herb-pairs, a case study on Astragali Radix-Fructus Corni

2016 ◽  
Vol 434 ◽  
pp. 219-237 ◽  
Author(s):  
Yu Duan ◽  
Ke Pei ◽  
Hao Cai ◽  
Sicong Tu ◽  
Xinwei Cheng ◽  
...  
2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Xiaoting Zheng ◽  
Liyang Lyu ◽  
Hong Lu ◽  
Yuanjia Hu ◽  
Ging Chan

AbstractWith the increasing demand for traditional Chinese medicine (TCM) in Portuguese-speaking countries (PSC), local regulatory systems and relevant legislation are still insufficient and lagging, even blank in some of them. This kind of unbalanced pace either makes users of TCM exposed in potential risk or eventually obstructs the long-term development of TCM in PSC. Despite existing tremendous studies on the internationalization of TCM, there are few studies specific to PSC. Thus, by a comprehensive desk review and typical case study, this article aims to summarize current situation of TCM in PSC by a cross-regional comparison, to identify various critical challenges, and further to provide an insightful reference to impel the development of TCM in PSC.


2021 ◽  
Vol 11 ◽  
Author(s):  
Bing Yang ◽  
Nan Yang ◽  
Yaping Chen ◽  
Maomao Zhu ◽  
Yuanpei Lian ◽  
...  

Lung cancer is one of the most devastating diseases worldwide, with high incidence and mortality worldwide, and the anticancer potential of traditional Chinese medicine (TCM) has been gradually recognized by the scientific community. Astragali Radix (AR) is commonly used in traditional Chinese medicine in the treatment of lung cancer and has a certain clinical effect, but effective components and targets are still unclear. In the study, we established an integrated strategy for effective-component discovery of AR in the treatment of lung cancer based on a variety of techniques. First, the effective components and potential targets of AR were deciphered by the “component-target-disease” network using network pharmacology, and potential signal pathways on lung cancer were predicted by Gene Ontology (GO) biological function enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Then, the therapeutic effects of AR in the treatment of lung cancer were evaluated in vivo using A/J mice, and the potential targets related to autophagy and potential signal pathway were verified by Western blot analysis, immunofluorescence staining, and real-time PCR technology at protein and gene expression level. Finally, metabolism in vitro by rat intestinal flora and cell membrane immobilized chromatography technology were used to screen the effective components of AR in the treatment of lung cancer, and remaining components from the cell immobilized chromatography were collected and analyzed by ultra-performance liquid chromatography–electrospray quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). The screening results of the integrated strategy showed that calycosin-7-O-β-D-glucoside, ononin, calycosin, astragaloside IV, astragaloside II, cycloastragenol, and formononetin may be effective components of AR in the treatment of lung cancer, and they may play a role in the treatment of lung cancer through autophagy and p53/AMPK/mTOR signaling pathway. The integrated strategy for effective-component discovery provided a valuable reference mode for finding the pharmacodynamic material basis of complex TCM systems. In addition, the prediction for targets and signal pathways laid a foundation for further study on the mechanism of AR in the treatment of lung cancer.


2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Lu Zou ◽  
Fengyu Lu ◽  
Bing Lin ◽  
Ying Zhou ◽  
Tingting Liu ◽  
...  

The drying process of Uncariae Ramulus Cum Uncis (URCU), a kind of traditional Chinese medicine, was studied in a scale dryer in laboratory at 65°C. It was observed that the alkaloids content of URCU firstly showed a tendency of increasing and then decreasing after reaching the peak at the 570th minute in the process of constant temperature drying. Moreover, the coagulation time of rabbit determined by test tubes has been adopted to study the effect imposed by the content of alkaloids on the anticoagulating activity of URCU. In addition, the software of Minitab was also utilized to fit the correlation between the content of alkaloids and the anticoagulating activity of URCU. The results obtained demonstrated that anticoagulant activities were available in both rhynchophylline and isorhynchophylline, among which the latter was the stronger one, while procoagulant activity was shown in corynoxeine. The case study can provide a useful reference for the research on drying other Chinese herbal medicines (CHMs) and further study on URCU.


RSC Advances ◽  
2020 ◽  
Vol 10 (17) ◽  
pp. 10338-10351 ◽  
Author(s):  
Libing Chen ◽  
Fang Zhao ◽  
Wenzhu Li ◽  
Zeqi Chen ◽  
Jianyang Pan ◽  
...  

Evaluation of a multiple and global analytical indicator of batch consistency was employed in TCMIs with a multivariate statistical tool.


Author(s):  
Arisara Jiamsanguanwong ◽  
Pattarapa Tientrakul ◽  
Fuanglada Sookseng ◽  
Chayapol Ophaswongse ◽  
Oran Kittithreerapronchai

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