scholarly journals Advances in the Regulation of Epidermal Cell Development by C2H2 Zinc Finger Proteins in Plants

2021 ◽  
Vol 12 ◽  
Author(s):  
Guoliang Han ◽  
Yuxia Li ◽  
Ziqi Qiao ◽  
Chengfeng Wang ◽  
Yang Zhao ◽  
...  
Keyword(s):  
Cell Fate ◽  
Zinc Finger ◽  
Epidermal Cell ◽  
Stress Responses ◽  
Root Hairs ◽  
Zinc Finger Proteins ◽  
Cell Development ◽  
Salt Glands ◽  
Plant Adaptation ◽  
C2h2 Zinc Finger

Plant epidermal cells, such as trichomes, root hairs, salt glands, and stomata, play pivotal roles in the growth, development, and environmental adaptation of terrestrial plants. Cell fate determination, differentiation, and the formation of epidermal structures represent basic developmental processes in multicellular organisms. Increasing evidence indicates that C2H2 zinc finger proteins play important roles in regulating the development of epidermal structures in plants and plant adaptation to unfavorable environments. Here, we systematically summarize the molecular mechanism underlying the roles of C2H2 zinc finger proteins in controlling epidermal cell formation in plants, with an emphasis on trichomes, root hairs, and salt glands and their roles in plant adaptation to environmental stress. In addition, we discuss the possible roles of homologous C2H2 zinc finger proteins in trichome development in non-halophytes and salt gland development in halophytes based on bioinformatic analysis. This review provides a foundation for further study of epidermal cell development and abiotic stress responses in plants.

scholarly journals Involvement of C2H2 zinc finger proteins in the regulation of epidermal cell fate determination in Arabidopsis

2014 ◽  
Vol 56 (12) ◽  
pp. 1112-1117 ◽  
Author(s):  
An Yan ◽  
Minjie Wu ◽  
Yongqin Zhao ◽  
Aidong Zhang ◽  
Bohan Liu ◽  
...  
Keyword(s):  
Cell Fate ◽  
Zinc Finger ◽  
Epidermal Cell ◽  
Zinc Finger Proteins ◽  
Cell Fate Determination ◽  
C2h2 Zinc Finger ◽  
Fate Determination

scholarly journals C2H2 Zinc Finger Proteins: Master Regulators of Abiotic Stress Responses in Plants

2020 ◽  
Vol 11 ◽  
Author(s):  
Guoliang Han ◽  
Chaoxia Lu ◽  
Jianrong Guo ◽  
Ziqi Qiao ◽  
Na Sui ◽  
...  
Keyword(s):  
Abiotic Stress ◽  
Zinc Finger ◽  
Stress Responses ◽  
Zinc Finger Proteins ◽  
C2h2 Zinc Finger ◽  
Master Regulators

scholarly journals Corrigendum: C2H2 Zinc Finger Proteins: Master Regulators of Abiotic Stress Responses in Plants

2020 ◽  
Vol 11 ◽  
Author(s):  
Guoliang Han ◽  
Chaoxia Lu ◽  
Jianrong Guo ◽  
Ziqi Qiao ◽  
Na Sui ◽  
...  
Keyword(s):  
Abiotic Stress ◽  
Zinc Finger ◽  
Stress Responses ◽  
Zinc Finger Proteins ◽  
C2h2 Zinc Finger ◽  
Master Regulators

scholarly journals Identification of non-Ser/Thr-Pro consensus motifs for Cdk1 and their roles in mitotic regulation of C2H2 zinc finger proteins and Ect2

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Kazuhiro Suzuki ◽  
Kosuke Sako ◽  
Kazuhiro Akiyama ◽  
Michitaka Isoda ◽  
Chiharu Senoo ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Proteins ◽  
C2h2 Zinc Finger ◽  
Consensus Motifs ◽  
Mitotic Regulation

The role of C2H2 zinc finger proteins in plant responses to abiotic stresses

2018 ◽  
Vol 165 (4) ◽  
pp. 690-700 ◽  
Author(s):  
Ke Wang ◽  
Yanfei Ding ◽  
Chong Cai ◽  
Zhixiang Chen ◽  
Cheng Zhu
Keyword(s):  
Zinc Finger ◽  
Abiotic Stresses ◽  
Zinc Finger Proteins ◽  
Plant Responses ◽  
C2h2 Zinc Finger

scholarly journals Supra-physiological levels of Gibberellins/DELLAs alter the patterning, morphology and abundance of root hairs in root tips of A. thaliana seedlings

2021 ◽  
Author(s):  
Iva McCarthy-Suarez
Keyword(s):  
Gene Expression ◽  
Cell Fate ◽  
Epidermal Cell ◽  
Root Hair ◽  
Root Hairs ◽  
Root Tip ◽  
Spatial Patterning ◽  
Root Tips ◽  
Root Epidermis

In spite of the known role of gibberellins (GAs), and of their antagonistic proteins, the DELLAs, in leaf hair production, no investigations, however, have assessed their hypothetical function in the production of root hairs. To this aim, the effects of supra-physiological levels of GAs/DELLAs on the spatial patterning of gene expression of the root hair (CPC) and root non-hair (GL2, EGL3 and WER) epidermal cell fate markers, as well as on the distribution, morphology and abundance of root hairs, were studied in root tips of 5-day-old A. thaliana seedlings. Results showed that excessive levels of GAs/DELLAs impaired the spatial patterning of gene expression of the root hair/non-hair epidermal cell fate markers, as well as the arrangement, shape and frequency of root hairs, giving rise to ectopic hairs and ectopic non-hairs, two-haired cells, two-tipped hairs, branched hairs, longer and denser hairs near the root tip under excessive DELLAs, and shorter and scarcer hairs near the root tip under excessive GAs. However, when the gai-1 (GA-insensitive-1) DELLA mutant protein was specifically over-expressed at the root epidermis, no changes in the patterning or abundance of root hairs occurred. Thus, these results suggest that, in seedlings of A. thaliana, the GAs/DELLAs might have a role in regulating the patterning, morphology and abundance of root hairs by acting from the sub-epidermal tissues of the root.

scholarly journals Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters

2020 ◽  
Vol 48 (11) ◽  
pp. 5986-6000 ◽  
Author(s):  
Weiya Ni ◽  
Andrew A Perez ◽  
Shannon Schreiner ◽  
Charles M Nicolet ◽  
Peggy J Farnham
Keyword(s):  
Dna Binding ◽  
Zinc Finger ◽  
Cpg Island ◽  
Zinc Finger Proteins ◽  
Double Knockout ◽  
Altered Expression ◽  
C2h2 Zinc Finger ◽  
Necessary And Sufficient ◽  
Functional Analyses

Abstract Our study focuses on a family of ubiquitously expressed human C2H2 zinc finger proteins comprised of ZFX, ZFY and ZNF711. Although their protein structure suggests that ZFX, ZFY and ZNF711 are transcriptional regulators, the mechanisms by which they influence transcription have not yet been elucidated. We used CRISPR-mediated deletion to create bi-allelic knockouts of ZFX and/or ZNF711 in female HEK293T cells (which naturally lack ZFY). We found that loss of either ZFX or ZNF711 reduced cell growth and that the double knockout cells have major defects in proliferation. RNA-seq analysis revealed that thousands of genes showed altered expression in the double knockout clones, suggesting that these TFs are critical regulators of the transcriptome. To gain insight into how these TFs regulate transcription, we created mutant ZFX proteins and analyzed them for DNA binding and transactivation capability. We found that zinc fingers 11–13 are necessary and sufficient for DNA binding and, in combination with the N terminal region, constitute a functional transactivator. Our functional analyses of the ZFX family provides important new insights into transcriptional regulation in human cells by members of the large, but under-studied family of C2H2 zinc finger proteins.

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