Correlation Between Maternal Smoking During Pregnancy and Dental Caries in Children: A Systematic Review and Meta-Analysis

Background: Dental caries is a long-standing oral health problem for children all over the world. The available evidence shows that the association between maternal smoking during pregnancy and childhood caries is still controversial. Therefore, the aim of this systematic review and meta-analysis was to determine whether there was a correlation of prenatal smoking and dental caries in children.Methods: PubMed, EMBASE, Cochrane, Web of Science, and Scopus databases were searched for observational studies assessing the relationship between maternal smoking during the pregnancy and childhood caries. According to the predesigned eligibility criteria and items, studies selection, and data extraction were conducted, respectively. The effect estimates were pooled using a fixed-effect model or a random-effect model. Newcastle-Ottawa Scale (NOS) was adopted to evaluate the methodological quality of the included studies. All analyses were carried out through Stata 12.0 software.Results: Our systematic review included a total of 11 studies, of which 6 cross-sectional studies and 3 longitudinal studies were included in the final meta-analysis. The pooled estimates indicated maternal smoking during pregnancy was significantly associated with dental caries in children both in cross-sectional studies (OR = 1.57, 95% CI = 1.47–1.67) and longitudinal studies (RR = 1.26, 95% CI = 1.07–1.48). Sensitivity analyses confirmed the overall effect estimates were robust.Conclusions: There is a significant correlation of maternal smoking during pregnancy and childhood caries. However, the causal relationship between them cannot be determined. More prospective and extensive studies on this theme is needed for verification. Even so, it is necessary for pregnant women and women of reproductive age to quit smoking. Strategies must be developed to raise public awareness about the impact of prenatal smoking on children's oral health.

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Maternal smoking during pregnancy and offspring body mass index and overweight: a systematic review and meta-analysis

Cadernos de Saúde Pública ◽

10.1590/0102-311x00176118 ◽

2019 ◽

Vol 35 (12) ◽

Cited By ~ 1

Author(s):

Elma Izze da Silva Magalhães ◽

Bruno Andrade de Sousa ◽

Natália Peixoto Lima ◽

Bernardo Lessa Horta

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Body Mass ◽

Maternal Smoking ◽

Meta Analysis ◽

Pooled Analysis ◽

Mean Difference ◽

Smoking During Pregnancy ◽

Smoking In Pregnancy ◽

Maternal Smoking During Pregnancy

Abstract: The present study aimed to conduct a systematic review and meta-analysis to evaluate the evidence on the association of maternal smoking during pregnancy with offspring body composition in childhood, adolescence and adulthood. MEDLINE, Web of Science and LILACS databases were searched. Reference lists were also screened. We included original studies, conducted in humans, that assessed the association of maternal smoking during pregnancy with offspring body mass index (BMI) and overweight in childhood, adolescence and adulthood, published through May 1st, 2018. A meta-analysis was used to estimate pooled effect sizes. The systematic review included 64 studies, of which 37 evaluated the association of maternal smoking during pregnancy with overweight, 13 with BMI, and 14 evaluated both outcomes. Of these 64 studies, 95 measures of effect were extracted and included in the meta-analysis. We verified that the quality of evidence across studies regarding maternal smoking in pregnancy and overweight and BMI of offspring to be moderate and low, respectively. Most studies (44 studies) were classified as moderate risk bias. Heterogeneity among studies included was high and, in the random-effects pooled analysis, maternal smoking during pregnancy increased the odds of offspring overweight (OR: 1.43, 95%CI: 1.35; 1.52) and mean difference of BMI (β: 0.31, 95%CI: 0.23; 0.39). In conclusion, offspring of mothers who smoked during pregnancy have higher odds of overweight and mean difference of BMI, and these associations persisted into adulthood.

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Maternal smoking during pregnancy and child overweight: systematic review and meta-analysis

International Journal of Obesity ◽

10.1038/sj.ijo.0803760 ◽

2007 ◽

Vol 32 (2) ◽

pp. 201-210 ◽

Cited By ~ 372

Author(s):

E Oken ◽

E B Levitan ◽

M W Gillman

Keyword(s):

Systematic Review ◽

Maternal Smoking ◽

Meta Analysis ◽

Smoking During Pregnancy ◽

Child Overweight ◽

Maternal Smoking During Pregnancy

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Effect of maternal smoking during pregnancy on Tourette syndrome and chronic tic disorders among offspring: a systematic review and meta-analysis

Obstetrics & Gynecology Science ◽

10.5468/ogs.20252 ◽

2020 ◽

Author(s):

Erfan Ayubi ◽

Kamyar Mansori ◽

Amin Doosti-Irani

Keyword(s):

Systematic Review ◽

Tourette Syndrome ◽

Maternal Smoking ◽

Meta Analysis ◽

Tic Disorders ◽

Smoking During Pregnancy ◽

Maternal Smoking During Pregnancy ◽

Chronic Tic Disorders

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Maternal smoking during pregnancy and birth defects in children: a systematic review with meta-analysis

Cadernos de Saúde Pública ◽

10.1590/0102-311x00115813 ◽

2014 ◽

Vol 30 (12) ◽

pp. 2491-2529 ◽

Cited By ~ 13

Author(s):

Dilvania Nicoletti ◽

Leilane Droppa Appel ◽

Pedro Siedersberger Neto ◽

Gabriel Waihrich Guimarães ◽

Linjie Zhang

Keyword(s):

Systematic Review ◽

Birth Defects ◽

Maternal Smoking ◽

Meta Analysis ◽

Smoking During Pregnancy ◽

Ovid Medline ◽

Maternal Smoking During Pregnancy ◽

Strength Of Association ◽

Dose Dependent ◽

Pregnancy And Birth

This systematic review aimed to investigate the association between maternal smoking during pregnancy and birth defects in children. We performed an electronic search of observational studies in the databases ovid MEDLINE (1950 to April 2010), LILACS and SciELO. We included 188 studies with a total of 13,564,914 participants (192,655 cases). Significant positive associations were found between maternal smoking and birth defects in the following body systems: cardiovascular (OR: 1.11; 95%CI: 1.03-1.19), digestive (OR: 1.18; 95%CI: 1.07-1.30), musculoskeletal (OR: 1.27; 95%CI: 1.16-1.39) and face and neck (OR: 1.28; 95%CI: 1.19-1.37). The strength of association between maternal smoking and birth defects measured by the OR (95%CI) is significantly related to the amount of cigarettes smoked daily (χ2 = 12.1; df = 2; p = 0.002). In conclusion, maternal smoking during pregnancy is associated with congenital malformations in children and this association is dose-dependent.

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