Comparison of Submucosal With Intramuscular or Intravenous Administration of Dexamethasone for Third Molar Surgeries: A Systematic Review and Meta-Analysis

Objective: The study aimed to review evidence on the efficacy of submucosal (SM) administration vs. intravenous (IV) or intramuscular (IM) route of injections of dexamethasone for improving outcomes after mandibular third molar surgery.Methods: PubMed, Embase, CENTRAL, and Google Scholar were searched for randomized controlled trials (RCTs) up to 20th May 2021. Early (2–3 days) and late (7 days) outcomes were compared between SM vs. IV or IM dexamethasone. Quality of evidence was assessed based on GRADE.Results: Thirteen trials were included in the systematic review and 10 in the meta-analysis. Meta-analysis indicated a significant reduction in early pain with IV dexamethasone but no such difference for late pain compared to the SM group. There was no difference in early and late swelling scores between the SM and IV groups. Pooled analysis indicated no significant difference in early and late trismus between SM and IV groups. Comparing SM with IM dexamethasone, there was no significant difference in early and late pain scores. Swelling in the early and late postoperative periods was not significantly different between the two groups. There was no significant difference in early and late trismus between SM and IM groups. The quality of evidence was low for all outcomes.Conclusion: Low-quality evidence suggests that SM infiltration of dexamethasone results in similar outcomes as compared to IV or IM administration of the drug after third molar surgeries. Further high-quality RCTs are needed to corroborate the current conclusions.

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Impact of platelet-rich fibrin on mandibular third molar surgery recovery: a systematic review and meta-analysis

BMC Oral Health ◽

10.1186/s12903-019-0824-3 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 5

Author(s):

Xu Xiang ◽

Ping Shi ◽

Ping Zhang ◽

Jun Shen ◽

Jian Kang

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Third Molar ◽

Third Molar Surgery ◽

Platelet Rich Fibrin ◽

Mandibular Third Molar ◽

Mandibular Third Molar Surgery

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Urgent-start peritoneal dialysis in chronic kidney disease patients: A systematic review and meta-analysis compared with planned peritoneal dialysis and with urgent-start hemodialysis

Peritoneal Dialysis International ◽

10.1177/0896860820918710 ◽

2020 ◽

pp. 089686082091871

Author(s):

Guo Xieyi ◽

Tang Xiaohong ◽

Wu Xiaofang ◽

Li Zi

Keyword(s):

Systematic Review ◽

Chronic Kidney Disease ◽

Peritoneal Dialysis ◽

Kidney Disease ◽

Meta Analysis ◽

Cochrane Central Register ◽

Exit Site Infection ◽

Quality Of Evidence ◽

Significant Difference

An increasing number of studies have focused on whether peritoneal dialysis (PD) can be used for the urgent initiation of dialysis in patients with chronic kidney disease (CKD). We performed this systematic review and meta-analysis to evaluate the feasibility and safety of urgent-start PD compared with those of planned PD and urgent-start hemodialysis (HD) in this population. PubMed, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), clinicaltrials.gov , and China National Knowledge Infrastructure (CNKI) were searched for relevant studies. Conference abstracts were also searched in relevant websites. The meta-analysis was performed using RevMan 5.3 software. A total of 15 trials involving 2426 participants were identified. The quality of the included studies was fair, but the quality of evidence was very low. Unadjusted meta-analysis showed that urgent-start PD had significantly higher mortality than planned PD, while adjusted meta-analysis did not show a significant difference. Higher incident of leakage and catheter mechanical dysfunction were observed in urgent-start PD. However, peritonitis, exit-site infection, or PD technique survival were comparable between urgent-start and planned PD. The all-cause mortality was comparable in urgent-start PD and urgent-start HD. Bacteremia was significantly lower in the urgent-start PD group than with urgent-start HD. Based on limited evidences, PD may be a viable alternative to HD for CKD patients requiring urgent-start dialysis. Because of the inconsistent results and the low quality of evidence, a definitive conclusion could not be drawn for whether urgent-start PD was comparable with planned PD. Therefore, high-quality and large-scale studies are needed in the future.

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Use of drugs to control pain, edema and trismus after mandibular third molar surgery: systematic review and network meta-analysis

10.37766/inplasy2020.6.0065 ◽

2020 ◽

Author(s):

Luciana Drugos ◽

Brunna Soares ◽

Joao Canellas ◽

Paulo Medeiros

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Third Molar ◽

Third Molar Surgery ◽

Mandibular Third Molar ◽

Mandibular Third Molar Surgery ◽

Control Pain

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Comparative efficacy and safety of different corticosteroids to reduce inflammatory complications after mandibular third molar surgery: a systematic review and network meta-analysis protocol

10.37766/inplasy2021.9.0023 ◽

2021 ◽

Author(s):

Joao Vitor Canellas ◽

◽

Fabio Ritto ◽

Paul Tiwana ◽

◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Third Molar ◽

Optimal Dose ◽

Third Molar Surgery ◽

Mandibular Third Molar ◽

Review Question ◽

Postoperative Inflammatory Complications ◽

Mandibular Third Molar Surgery ◽

Analysis Protocol

Review question / Objective: This systematic review aims to compare the effects of different corticosteroids to reduce postoperative inflammatory complications (pain, edema, and trismus) after mandibular third molar surgery by applying a frequentist network meta-analysis approach. To this end, the proposed study will answer the following questions: 1) Among diverse corticosteroids currently available, what is the best preoperative option to control postoperative inflammatory complications? 2) What is the optimal dose and route of administration of corticosteroids prior to mandibular third molar surgery to control the pain, edema, and trismus induced by the surgery? Condition being studied: Inflammatory complications after mandibular third molar surgery (Pain, edema, and trismus).

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