scholarly journals Adenoviral CD40 Ligand Immunotherapy in 32 Canine Malignant Melanomas–Long-Term Follow Up

2021 ◽  
Vol 8 ◽  
Author(s):  
Sara Saellstrom ◽  
Arian Sadeghi ◽  
Emma Eriksson ◽  
Thomas Segall ◽  
Maria Dimopoulou ◽  
...  
Keyword(s):  
World Health Organization ◽  
Tumor Biology ◽  
Stage Iv ◽  
Metastatic Potential ◽  
Cd40 Ligand ◽  
World Health ◽  
Beneficial Effects ◽  
Serious Disease ◽  
Canine Melanoma ◽  
Health Organization

Malignant melanoma is a serious disease in both humans and dogs, and the high metastatic potential results in poor prognosis for many patients. Its similarities with human melanoma make spontaneous canine melanoma an excellent model for comparative studies of novel therapies and tumor biology. Gene therapy using adenoviruses encoding the immunostimulatory gene CD40L (AdCD40L) has shown promise in initial clinical trials enrolling human patients with various malignancies including melanoma. We report a study of local AdCD40L treatment in 32 cases of canine melanoma (23 oral, 5 cutaneous, 3 ungual and 1 conjunctival). Eight patients were World Health Organization (WHO) stage I, 9 were stage II, 12 stage III, and 3 stage IV. One to six intratumoral injections of AdCD40L were given every seven days, combined with cytoreductive surgery in 20 cases and only immunotherapy in 12 cases. Tumor tissue was infiltrated with T and B lymphocytes after treatment, suggesting immune stimulation. The best overall response based on result of immunotherapy included 7 complete responses, 5 partial responses, 5 stable and 2 progressive disease statuses according to the World Health Organization response criteria. Median survival was 285 days (range 20–3435 d). Our results suggest that local AdCD40L therapy is safe and could have beneficial effects in dogs, supporting further treatment development. Clinical translation to human patients is ongoing.

scholarly journals Intestinal microbiota in children with obesity. Role of probiotics

2020 ◽  
pp. 134-142
Author(s):  
I. N. Zakharova ◽  
I. V. Berezhnaya ◽  
E. V. Skorobogatova ◽  
M. R. Aysanova ◽  
T. I. Bocharova
Keyword(s):  
World Health Organization ◽  
Intestinal Microbiota ◽  
Metabolic Activity ◽  
Scientific Evidence ◽  
World Health ◽  
Obese People ◽  
Beneficial Effects ◽  
Control Factors ◽  
The World ◽  
Health Organization

Obesity is a global problem of modern healthcare. In 2016, the World Health Organization estimated that 39% of people over 18 were overweight, and the number of obese people worldwide almost tripled over the period from 1975 to 2016. The number of overweight and obese children is growing at an alarming rate, with the World Health Organization estimating that in 2016 the number of overweight children under the age of 5 will exceed 41 million. Scientific evidence supports the hypothesis that the development of obesity is closely related to changes in both the function and composition of the intestinal microbiota, which plays a significant role in controlling energy metabolism and changes in body mass index. The main therapy for obesity and associated metabolic disorders to date has been a corrected diet combined with physical activity. The new therapeutic strategy for the treatment and prevention of obesity is based on changing the metabolic activity of the intestinal microbiota using probiotics. Studies on changes in metabolic activity and obesity in rodents have shown encouraging results. The beneficial effects of probiotics on human health today no longer require proof. Probiotics have an integrated effect on the physical, biochemical and metabolic parameters associated with obesity, combined with adequate nutrition and lifestyle correction. Probiotics in the presence of prebiotics have more pronounced metabolic functions, help stabilize the intestinal microbiota, maintain a healthy body weight and control factors associated with fat accumulation and chronic inflammation.

World Health Organization Self-Reporting Questionnaire 20--Tigrigna Version

2018 ◽  
Author(s):  
Tesfit Brhane Netsereab ◽  
Meron Mehari Kifle ◽  
Robel Berhane Tesfagiorgis ◽  
Sara Ghebremichael Habteab ◽  
Yosan Kahsay Weldeabzgi ◽  
...  
Keyword(s):  
World Health Organization ◽  
World Health ◽  
Health Organization ◽  
Self Reporting Questionnaire

Erstes Instrument zur standardisierten Erfassung der Teilhabe Behinderter

2017 ◽  
Vol 79 (07) ◽  
pp. 526-527
Keyword(s):  
World Health Organization ◽  
World Health ◽  
The World ◽  
Health Organization ◽  
Menschen Mit Behinderung

Coenen M et al. [Recommendation for the collection and analysis of data on participation and disability from the perspective of the World Health Organization]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2016; 59: 1060–1067 Um eine gleichberechtigte Teilhabe an der Gesellschaft von Menschen mit Behinderung zu ermöglichen, werden zunächst Daten zu vorhandenen Einschränkungen gebraucht. Erst wenn diese detailliert erhoben wurden, können Konzepte zur Beseitigung von Problemen entwickelt werden. Ein standardisiertes Erhebungsinstrument für alle Aspekte der Funktionsfähigkeit fehlte jedoch bisher.

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