scholarly journals Analgesic Effect of Butorphanol during Castration in Donkeys under Total Intravenous Anaesthesia

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2346
Author(s):  
Paola Straticò ◽  
Augusto Carluccio ◽  
Vincenzo Varasano ◽  
Giulia Guerri ◽  
Riccardo Suriano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Analgesic Effect ◽  
Scientific Evidence ◽  
Muscle Relaxation ◽  
Repeated Measure ◽  
Muscle Rigidity ◽  
Total Intravenous Anaesthesia ◽  
Intravenous Anaesthesia ◽  
Duration Of Surgery ◽  
Group D

Pain management is necessary for all surgical procedures. Little scientific evidence about drug efficacy in donkeys is available. The aim of this study was to evaluate the analgesic effect of butorphanol in donkeys undergoing orchiectomy under total intravenous anaesthesia with guaifenesin-ketamine-detomidine. A randomized blinded prospective clinical trial (Protocol n. 2021/0000338), was carried out on 18 clinically healthy donkeys undergoing bilateral orchiectomy. Patients were assigned to Group D (n = 8) or Group DB (n = 10) if receiving intravenous detomidine or detomidine-butorphanol respectively, before induction of general anaesthesia with ketamine-diazepam. Intraoperative muscle relaxation, nystagmus, palpebral reflex, heart and respiratory rate, and non-invasive blood pressure were evaluated every 2 min; time to prepare the patient, duration of surgery and anaesthesia and recovery score were recorded. Group D had significantly longer surgical time, higher heart rate, higher systolic and mean blood pressure (p < 0.05; repeated measure ANOVA), increased muscle rigidity and expression of palpebral reflex (p < 0.05; Mann–Whitney U test) than group DB. Top-ups with thiopental were statistically higher in Group D. Butorphanol and detomidine together produced a more stable anaesthetic plan. The low dosage of opioid and alpha-2-agonists and reduced rescue anaesthesia are responsible for a safer and more superficial anaesthesia, which is mandatory under field conditions.

scholarly journals Intravenous anaesthesia in goats: A review

2013 ◽  
Vol 84 (1) ◽  
Author(s):  
T. Brighton Dzikiti
Keyword(s):  
General Anaesthesia ◽  
Muscle Relaxation ◽  
Scientific Information ◽  
Working Environment ◽  
Total Intravenous Anaesthesia ◽  
Intravenous Anaesthesia ◽  
Anaesthetic Agents ◽  
Inhalation Anaesthetic ◽  
Intravenous Anaesthetic ◽  
Balanced Anaesthesia

Intravenous anaesthesia is gradually becoming popular in veterinary practice. Traditionally, general anaesthesia is induced with intravenous drugs and then maintained with inhalation agents. Inhalation anaesthetic agents cause more significant dose-dependent cardiorespiratory depression than intravenous anaesthetic drugs, creating a need to use less of the inhalation anaesthetic agents for maintenance of general anaesthesia by supplementing with intravenous anaesthesia drugs. Better still, if anaesthesia is maintained completely with intravenous anaesthetic drugs, autonomic functions remain more stable intra-operatively. Patient recovery from anaesthesia is smoother and there is less pollution of the working environment than happens with inhalation anaesthetic agents. Recently, a number of drugs with profiles (pharmacokinetic and pharmacodynamic) suitable for prolonged intravenous anaesthesia have been studied, mostly in humans and, to a certain extent, in dogs and horses. There is currently very little scientific information on total intravenous anaesthesia in goats, although, in the past few years, some scholarly scientific articles on drugs suitable for partial intravenous anaesthesia in goats have been published. This review article explored the information available on drugs that have been assessed for partial intravenous anaesthesia in goats, with the aim of promoting incorporation of these drugs into total intravenous anaesthesia protocols in clinical practice. That way, balanced anaesthesia, a technique in which drugs are included in anaesthetic protocols for specific desired effects (hypnosis, analgesia, muscle relaxation, autonomic stabilisation) may be utilised in improving the welfare of goats undergoing general anaesthesia.

scholarly journals Comparison of Balanced General and Total Intravenous Anaesthesia for Gasser Ganglion Percutaneous Balloon Microcompression for Trigeminal Neuralgia

2021 ◽  
pp. 1-3
Author(s):  
Patricia Heise ◽  
◽  
Marcos Baabor ◽  
Claudia Marin ◽  
◽  
...  
Keyword(s):  
Blood Pressure ◽  
Trigeminal Neuralgia ◽  
General Anaesthesia ◽  
Total Intravenous Anaesthesia ◽  
Intravenous Anesthesia ◽  
Intravenous Anaesthesia ◽  
Percutaneous Balloon ◽  
Group A ◽  
Group B ◽  
To Receive

Objective: To compare the effectiveness between balanced general anaesthesia and total intravenous anaesthesia for the hemodynamic control of patients undergoing percutaneous balloon microcompression of the Gasser’s ganglion in trigeminal neuralgia. Patients and methods: A retrospective trial was conducted in thirty patients with the diagnosis of essential trigeminal neuralgia, aged 37 to 82 years old, ASA I and II. The participants were randomly allocated in two groups: Group A, to receive balanced general anaesthesia (BGA) with isoflurane/fentanyl, or Group B, to receive total intravenous anesthesia (TIVA) with propofol/remifentanil. The systolic, diastolic and mean arterial blood pressure, heart rate and oximetry were measured at basal state, entrance to Meckel’s cavum and during the balloon compression. Statistical analysis with the Student T test for continuous quantitative variables and x2 (Chi square) for qualitative variables was performed. Results: The systolic blood pressure was significantly higher in group A at the moment of greatest stimulation. The technique propofol/remifentanil (group B) obtained better hemodynamic control and its management was easier. The incidence of bradycardia was similar in both groups and kept inverse relation with use of previous atropine. Conclusions: Total intravenous anesthesia (TIVA) is an attractive alternative to balanced general anesthesia due to the better hemodynamic response and the quick recovery that this technique offers. Moreover, Atropine use before the procedure is a measure that could benefit patients

Comparison of two injectable anaesthetic techniques on induction and subsequent anaesthesia in pigs

2021 ◽  
pp. 002367722110298
Author(s):  
Anneli Ryden ◽  
Sheila Fisichella ◽  
Gaetano Perchiazzi ◽  
Görel Nyman
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Anaesthetic Techniques ◽  
Total Intravenous Anaesthesia ◽  
Depth Of Anaesthesia ◽  
Intravenous Anaesthesia ◽  
Physiological Variables ◽  
Arterial Blood ◽  
Nociceptive Stimulus ◽  
Free Induction

Pig experiments often require anaesthesia, and a rapid stress-free induction is desired. Induction drugs may alter the subsequent anaesthesia. Therefore, the aim of the present study was to compare, in pigs, the effects of two different injectable anaesthetic techniques on the induction and on the physiological variables in a subsequent eight hours of total intravenous anaesthesia (TIVA). Twelve domestic castrates (Swedish Landrace/Yorkshire) 27‒31 kg were used. The pigs were randomly assigned to different induction drug combinations of zolazepam–tiletamine and medetomidine intramuscularly (ZTMe) or midazolam, ketamine intramuscularly and fentanyl intravenously (MiKF). Time from injection to unconsciousness was recorded and the ease of endotracheal intubation assessed. The TIVA infusion rate was adjusted according to the response exhibited from the nociceptive stimulus delivered by mechanically clamping the dewclaw. The time from injection to unconsciousness was briefer and intubation was easier in the ZTMe group. Results from the recorded heart rate, cardiac index and arterial blood pressure variables were satisfactorily preserved and cardiovascular function was maintained in both groups. Shivering was not observed in the ZTMe group, but was observed in four of the pigs in the MiKF group. The requirement of TIVA was lower in the ZTMe group. In conclusion, ZTMe had better results than MiKF in areas such as shorter induction time, better intubation scoring results and less adjustment and amount of TIVA required up to six hours of anaesthesia. The results may have been due to a greater depth of anaesthesia achieved with the ZTMe combination at the dose used.

scholarly journals Analgesic Effect of Tramadol and Buprenorphin in Continuous Propofol Anaesthesia

2016 ◽  
Vol 60 (1) ◽  
pp. 47-52
Author(s):  
I. Capík ◽  
O. Nagy
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Respiratory Rate ◽  
Analgesic Effect ◽  
Dental Treatment ◽  
Negative Influence ◽  
Tramadol Hydrochloride ◽  
Intravenous Anaesthesia ◽  
Arterial Blood ◽  
Pain Reaction

Abstract The objective of this study was to compare in clinical patients the analgesic effect of the centrally acting analgesics tramadol and buprenorphine in continuous intravenous anaesthesia (TIVA) with propofol. Twenty dogs undergoing prophylactic dental treatment, aged 2−7 years, weighing 6−27 kg, were included in ASA I. and II. groups. Two groups of dogs received intravenous (IV) administration of tramadol hydrochloride (2 mg.kg−1) or buprenorphine hydrochloride (0.2 mg.kg−1) 30 minutes prior to sedation, provided by midazolam hydrochloride (0.3 mg.kg−1) and xylazine hydrochloride (0.5 mg.kg-1) IV. General anaesthesia was induced by propofol (2 mg.kg−1) and maintained by a 120 minutes propofol infusion (0.2 mg.kg−1min−1). Oscilometric arterial blood pressure (ABP) measured in mm Hg, heart rate (HR), respiratory rate (RR), SAT, body temperature (BT) and pain reaction elicited by haemostat forceps pressure at the digit were recorded in ten minute intervals. The tramadol group of dogs showed significantly better parameters of blood pressure (P < 0.001), lower tendency to bradycardia (P < 0.05), and better respiratory rate (P < 0.001) without negative influence to oxygen saturation. Statistically better analgesia was achieved in the tramadol group (P < 0.001). Tramadol, in comparison with buprenorphine provided significantly better results with respect to the degree of analgesia, as well as the tendency of complications arising during anaesthesia.

Comparison of Total Intravenous, Balanced Inhalational and Combined Intravenous-Inhalational Anaesthesia for Tympanoplasty, Septorhinoplasty and Adenotonsillectomy

1995 ◽  
Vol 23 (5) ◽  
pp. 574-582 ◽  
Author(s):  
A. A. Van Den Berg ◽  
D. Savva ◽  
N. M. Honjol ◽  
N. V. Rama Prabhu
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Anaesthetic Techniques ◽  
Total Intravenous Anaesthesia ◽  
Intravenous Anaesthesia ◽  
Haemodynamic Stability ◽  
Inhalational Anaesthetic ◽  
Inhalational Anaesthesia ◽  
Intravenous Anaesthetic ◽  
Induction Of Anaesthesia

Two hundred and thirty-five consecutive Saudi patients aged between two and fifty-three years undergoing elective tympanoplasty (n = 32), septorhinoplasty (n = 68) or adenotonsillectomy (n=135) were studied. They were randomized to receive either a total intravenous anaesthetic (10 ears, 23 noses, 44 throats) consisting of propofol for induction of anaesthesia followed by a propofol infusion, a combined intravenous-inhalational anaesthetic (11 ears, 22 noses, 46 throats) consisting of the above with isoflurane in oxygen-enriched air, or a balanced inhalational anaesthetic (11 ears, 23 noses, 45 throats) consisting of thiopentone for induction of anaesthesia and oxygen in nitrous oxide with isoflurane for maintenance. During tympanoplasty, all three anaesthetic techniques produced stable heart rates and arterial pressures. During septorhinoplasty, blood pressure rose in patients who received total intravenous anaesthesia, while combined and balanced techniques produced haemodynamic stability. During adenotonsillectomy, total intravenous anaesthesia produced a rise in both heart rate and blood pressure, the combined technique produced a rise in heart rate alone while balanced anaesthesia produced haemodynamic stability. Postoperatively, vomiting, pain scores and analgesic requirements were similar following all three types of anaesthetic within each surgical site subgroup. Our findings support the choice of balanced inhalational anaesthesia for all three types of ENT surgery and, where cost and facilities permit, total intravenous anaesthesia for tympanoplasty and combined intravenous-inhalational anaesthesia for septorhinoplasty.

Assessing the eligibility of a non-invasive continuous blood pressure measurement technique for application during total intravenous anaesthesia

2016 ◽  
Vol 61 (3) ◽  
pp. 369-379
Author(s):  
Robert Huhle ◽  
Joachim Siegert ◽  
Fred Wonka ◽  
Christoph Schindler ◽  
Marcelo Gama de Abreu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Linear Trend ◽  
Blood Pressure Measurement ◽  
Patient Specific ◽  
Total Intravenous Anaesthesia ◽  
Data Set ◽  
Intravenous Anaesthesia ◽  
Non Invasive ◽  
Arterial Blood ◽  
Pressure Changes

Abstract Objective: To assess the eligibility for replacement of invasive blood pressure as measured “within” the arterial vessel (IBP) with non-invasive continuous arterial blood pressure (cNIP) monitoring during total intravenous anaesthesia (TIVA), the ability of cNiP to track fast blood pressure changes needs to be quantified. A new method of statistical data analysis is developed for this purpose. Methods: In a pilot study on patients undergoing neurosurgical anaesthesia, mean arterial pressure MAPIBP measured with IBP was compared to MAPCNP measured by the CNAP Monitor 500 in ten patients (age: 63±13 a). Correlation analysis of changes of device differences ΔeMAP=ΔMAPCNP-ΔMAPIBP with changes of MAPIBP (ΔMAPIBP) during intervals of vasoactivity was conducted. An innovative technique, of linear trend analysis (LTA) applied to two signals, is described to perform this analysis without a priori knowledge of intervals of vasoactivity. Results: Analysis of ΔeMAP during vasoactivity revealed that ΔMAPCNP systematically underestimated ΔMAPIBP by 37%. This was confirmed in the complete data set using LTA technique showing a systematic, yet patient specific, underestimation in tracking ΔMAPIBP (16…120%). Conclusion: The proposed LTA technique is able to detect systematic errors in tracking short-term blood pressure changes otherwise masked by established analysis. LTA may thus be a useful tool to assess the eligibility of cNIP to replace IBP during TIVA.

scholarly journals A comparison of the effects of desflurane and total intravenous anaesthesia on the motor evoked responses in scoliosis surgery

2017 ◽  
Vol 5 (3) ◽  
pp. 1015 ◽  
Author(s):  
Betul Isik ◽  
Güldem Turan ◽  
Suheyla Abitagaoglu ◽  
Osman Ekinci ◽  
Asu Özgültekin
Keyword(s):  
Scoliosis Surgery ◽  
Total Intravenous Anaesthesia ◽  
Intravenous Anaesthesia ◽  
Surgical Suture ◽  
Perioperative Bleeding ◽  
Study Results ◽  
Train Of Four ◽  
Orientation Time ◽  
End Tidal ◽  
Group D

Background: In the present study, we compared the effects of total intravenous anaesthesia (TIVA) and desflurane anaesthesia on tcMEPs in scoliosis surgery.Methods: The study included 45 patients between the ages of 18 to 50 years, and classified as ASAI-II; which were planned to undergo posterior fusion/instrumentation operations for elective scoliosis.  Anaesthesia was maintained using 50-150 mcg/kg/min propofol in Group T(TIVA), and desflurane (0.5 MAC) in Group D, and with infusions of 0.05-0.3 mcg/kg/min remifentanil at 50 % O2 + air in both groups, by applying drugs at doses so that bispectral index (BIS) would be maintained between 40 and 60 throughout the course of anaesthesia. The tcMEP responses were measured four times during the operation, and BIS, train-of-four (TOF), mean arterial pressure (MAP), heart rate(HR), and end tidal CO2(ETCO2) values were recorded simultaneously. In both group the anaesthesia was ended at the final surgical suture.  The recovery parameters were recorded.Results: The groups were found not to differ regarding the demographic characteristics, duration of the anaesthesia and the surgery, remifentanil dosage, tcMEP, the simultaneously recorded TOF, MAP, HR and ETCO2 values, and the amount of perioperative bleeding. The cooperation time and the orientation time were shorter in group D. The tcMEP responses were recorded in the appropriate times and amplitudes in both groups. Conclusions: TIVA is primarily used in routine applications in spinal surgery; however our study results revealed that 0.5 MAC desflurane may also be safely used in association with remifentanil, with the resultant correct tcMEP responses.  

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