scholarly journals Encapsulation of Phenolic Compounds from a Grape Cane Pilot-Plant Extract in Hydroxypropyl Beta-Cyclodextrin and Maltodextrin by Spray Drying

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1130
Author(s):  
Danilo Escobar-Avello ◽  
Javier Avendaño-Godoy ◽  
Jorge Santos ◽  
Julián Lozano-Castellón ◽  
Claudia Mardones ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Inclusion Complex ◽  
Spray Drying ◽  
Plant Extract ◽  
Pilot Plant ◽  
Encapsulation Efficiency ◽  
Water Soluble ◽  
Total Extract ◽  
Beta Cyclodextrin ◽  
Hydroxypropyl Beta Cyclodextrin

Grape canes, the main byproducts of the viticulture industry, contain high-value bioactive phenolic compounds, whose application is limited by their instability and poorly solubility in water. Encapsulation in cyclodextrins allows these drawbacks to be overcome. In this work, a grape cane pilot-plant extract (GCPPE) was encapsulated in hydroxypropyl beta-cyclodextrin (HP-β-CD) by a spray-drying technique and the formation of an inclusion complex was confirmed by microscopy and infrared spectroscopy. The phenolic profile of the complex was analyzed by LC-ESI-LTQ-Orbitrap-MS and the encapsulation efficiency of the phenolic compounds was determined. A total of 42 compounds were identified, including stilbenes, flavonoids, and phenolic acids, and a complex of (epi)catechin with β-CD was detected, confirming the interaction between polyphenols and cyclodextrin. The encapsulation efficiency for the total extract was 80.5 ± 1.1%, with restrytisol showing the highest value (97.0 ± 0.6%) and (E)-resveratrol (32.7 ± 2.8%) the lowest value. The antioxidant capacity of the inclusion complex, determined by ORAC-FL, was 5300 ± 472 µmol TE/g DW, which was similar to the value obtained for the unencapsulated extract. This formulation might be used to improve the stability, solubility, and bioavailability of phenolic compounds of the GCPPE for water-soluble food and pharmaceutical applications.

scholarly journals Spray drying encapsulation of a native plant extract rich in phenolic compounds with combinations of maltodextrin and non-conventional wall materials

2020 ◽  
Vol 57 (11) ◽  
pp. 4111-4122 ◽  
Author(s):  
María José Navarro-Flores ◽  
Lucía María C. Ventura-Canseco ◽  
Rocío Meza-Gordillo ◽  
Teresa del Rosario Ayora-Talavera ◽  
Miguel Abud-Archila
Keyword(s):  
Phenolic Compounds ◽  
Spray Drying ◽  
Plant Extract ◽  
Native Plant ◽  
Wall Materials

Permeation of Hydroxypropyl-Beta-Cyclodextrin and Its Inclusion Complex through Mouse Small Intestine, Determined by a Spectrophotometry

2021 ◽  
Vol 17 ◽  
Author(s):  
Ping Yang ◽  
Jinhua Luo ◽  
Shuo Yan ◽  
Xiaohong Li ◽  
Qian Yao
Keyword(s):  
Small Intestine ◽  
Inclusion Complex ◽  
Host Molecules ◽  
Beta Cyclodextrin ◽  
Mouse Small Intestine ◽  
Ft Ir ◽  
Hydroxypropyl Beta Cyclodextrin ◽  
Assay Conditions

Background: Cyclodextrins (CDs) are commonly used host molecules of inclusion complex. However, due to the lack of sensitive method to determine CDs, the absorption process of CDs remains unclear. Objective: In this study, oleuropein (OL) inclusion complex employing hydroxylpropyl-beta-cyclodextrin (HP-beta-CD) as host molecules was prepared and the formation of inclusion complex was ascertained by FT-IR and DSC. A spectrophotometry was established for the determination of HP-beta-CD, based on the fact that the absorbance of phenolphthalein (PP) decreased in the presence of HP-beta-CD. Methods: The assay conditions were optimized to augment the method sensitivity. Molecular docking was employed to verify the strong interaction between PP and HP-beta-CD. The permeation process of free HP-beta-CD, HP-beta-CD of OL inclusion complex, free OL, and OL in the inclusion complex, was examined, respectively, using an in vitro mouse small intestine model. Results: Though HP-beta-CD possessed hydrophilic outside shell, it could permeate through mouse small intestine quickly with cumulative permeating amount over 90% in 2 h. Free HP-beta-CD, the host molecule HP-beta-CD, and guest molecule OL of the inclusion complex exhibited the consistent permeating profiles across mouse small intestine. Conclusion: The approach for the determination of HP-beta-CD was accurate and precise (%RSD=2.98).

scholarly journals Effect of Spray Drying on the Microencapsulation of Blueberry Natural Antioxidants

Proceedings ◽  
2020 ◽  
Vol 70 (1) ◽  
pp. 26
Author(s):  
Mariana S. Lingua ◽  
Virginia Salomón ◽  
María V. Baroni ◽  
Jesica E. Blajman ◽  
Luis María Maldonado ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Moisture Content ◽  
Spray Drying ◽  
Encapsulation Efficiency ◽  
Water Solubility ◽  
Phenolic Content ◽  
Natural Antioxidants ◽  
Total Phenolic ◽  
Inlet Temperature ◽  
Food Ingredients

Phenolic compounds obtained from blueberries have gained great attention due to their more effective bioactive roles in human health than those of whole berries. However, they are sensitive to environmental conditions and are therefore susceptible to degradation affecting their effectiveness. The microencapsulation of these compounds by spray drying provides a solution to these problems. This work aimed to study the effect of spray drying on the microencapsulation of the blueberry phenolic compounds to optimize the production of a powder rich in stable polyphenols. The phenolic extract from blueberries was spray dried under different conditions of inlet air temperatures (140 and 160 °C) and encapsulating agent concentrations (20 and 30% w/v), using maltodextrin (14.7 dextrose equivalent). The drying yield, moisture content, water-solubility, total and surface phenolic content, and encapsulation efficiency of total phenolic were investigated. The results obtained showed that the different conditions evaluated influenced the drying yield, moisture content, surface phenolic content, and encapsulation efficiency of phenolic compounds. In this sense, the powders with the best characteristics were obtained with 30% w/v of maltodextrin at 160 °C inlet temperature. These powders, rich in blueberry polyphenols stabilized by microencapsulation, are easier to handle for application, so they could be used as functional food ingredients.

scholarly journals Preparation and characterization of cyanazine–hydroxypropyl-beta-cyclodextrin inclusion complex

RSC Advances ◽  
2019 ◽  
Vol 9 (45) ◽  
pp. 26109-26115 ◽  
Author(s):  
Shuang Gao ◽  
Chao Bie ◽  
Qiuyu Ji ◽  
Haiyang Ling ◽  
Chunyan Li ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Inclusion Complex ◽  
Water Solubility ◽  
Herbicidal Activity ◽  
Beta Cyclodextrin ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex ◽  
Hydroxypropyl Beta Cyclodextrin

Cyanazine/HPβCD inclusion complex was prepared to improve water solubility and thermal stability and herbicidal activity of cyanazine.

scholarly journals Encapsulation of lycopene using spray-drying and molecular inclusion processes

2007 ◽  
Vol 50 (5) ◽  
pp. 893-900 ◽  
Author(s):  
Itaciara Larroza Nunes ◽  
Adriana Zerlotti Mercadante
Keyword(s):  
Spray Drying ◽  
Encapsulation Efficiency ◽  
Freeze Drying ◽  
Molar Ratio ◽  
Powder Form ◽  
Average Yield ◽  
Irregular Structures ◽  
Beta Cyclodextrin ◽  
Pale Pink ◽  
Molecular Inclusion

This study aimed to obtain encapsulated lycopene in a powder form, using either spray-drying or molecular inclusion with beta -cyclodextrin ( beta -CD) followed by freeze-drying. The encapsulation efficiency using spray-drying ranged from 94 to 96%, with an average yield of 51%, with microcapsules showing superficial indentations and lack of cracks and breakages. Lycopene- beta -CD complexes were only formed at a molar ratio of 1:4, and irregular structures of different sizes that eventually formed aggregates, similar to those of beta -CD, were observed after freeze-drying. About 50% of the initial lycopene did not form complexes with beta -CD. Lycopene purity increased from 96.4 to 98.1% after spray-drying, whereas lycopene purity decreased from 97.7 to 91.3% after complex formation and freeze-drying. Both the drying processes yielded pale-pink, dry, free-flowing powders.

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