Decreasing the Likelihood of Multiple Organ Dysfunction Syndrome in Burn Injury with Early Antioxidant Treatment

Major burn trauma initiates a cascade of physiological events that cause profound stress on the body, resulting in significant complications which often lead to death. An understanding of these events may afford earlier and more precise interventions which, in turn, may reduce these complications, thus, improving patient outcomes. Burn trauma is associated with numerous inflammatory events that result in the release of free radicals, which promote oxidative stress and subsequent tissue damage. These mass-inflammatory events affect the body systemically, leading to several detrimental responses including complement activation, excessive histamine release, decrease in blood pressure, release of reactive oxygen species, and ultimately multiple organ dysfunction syndrome (MODS). However, recent studies conducted on the use of antioxidants as a part of a burn treatment protocol have shown promising results. In this review, we will discuss the current research and advancements in the treatment of burn trauma with the use of antioxidants, and how the early administration of antioxidant can possibly reduce the risk of developing MODS.

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Multiple Organ Dysfunction Syndrome In Major Burns Patients

Medicine Today ◽

10.3329/medtoday.v22i2.12438 ◽

2012 ◽

Vol 22 (2) ◽

pp. 75-79 ◽

Cited By ~ 1

Author(s):

Mohammad Shaha Alam ◽

Syeda Humaira Begum

Keyword(s):

Organ Dysfunction ◽

Burn Injury ◽

Multiple Organ ◽

Inhalation Injury ◽

Age Group ◽

Multiple Organ Dysfunction ◽

Major Burn ◽

Liver And Pancreas ◽

Medicine Today ◽

Organ Dysfunctions

Organ dysfunctions are frequent after major burn trauma. Development of MODS in severely burned patients is highly fatal. The present study was conducted to elucidate the etiology and quantify the Multiple Organ Dysfunction (MODS) in major burn patients. Multiple organ dysfunctions in major burnt patients was a prospective analytic study. A total of thirty patients were included in the study, which was conducted in the Burn and Plastic Surgery unit, Bir Hospital, Kathmondu, Nepal over the period of eighteen months from January 2002 to June 2003. Patients with acute major burn i.e. 24 hours from the time of injury were admitted and included in the study. All patients were initially treated in the ICU of burn unit. Among 30 patients, 25 patients were in the age group 15-30 years and 5 patients were in the 31- 60 years age group. 12 patients were male and 18 were female. 93.3% of patients in this study had sustained flame burn and the chief mode of burn injury was accidental 50% whereas 46.7% were suicidal. 66.7% of the patients had 20% - 50%TBSA and 33.3% had sustained 50% - 90% TBSA burn. Majority of the patients were under went early excision and SSG with regular dressing. 63.3 % (19 patients) develop multiple organ dysfunctions and most frequently involved organ was kidneys and followed by lungs, liver and pancreas. Among the multiple organ failure patients, 10 had developed septicemia. None of the patients were found to have developed cardiac failure. The mortality in the study population was 46.7%, all of them had MODS and 9 of them had inhalation injury. It was also seen that MODS can Medicine Today 2010 Volume 22 Number 02 Page 75-79 DOI: http://dx.doi.org/10.3329/medtoday.v22i2.12438

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Multiple Organ Dysfunction Syndrome of Alcoholic Origin in an 18-Year-Old Patient

The International Annals of Medicine ◽

10.24087/iam.2018.2.12.712 ◽

2018 ◽

Vol 2 (12) ◽

Author(s):

Francesco Gazia ◽

Giacomo De Luca ◽

Imbalzano Gabriele ◽

Vincenzo Pellicanò

Keyword(s):

Organ Dysfunction ◽

Multiple Organ Dysfunction Syndrome ◽

Multiple Organ ◽

Multiple Organ Dysfunction

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IMPACT probability of poor outcome and plasma cytokine concentrations are associated with multiple organ dysfunction syndrome following traumatic brain injury

Journal of Neurosurgery ◽

10.3171/2018.8.jns18676 ◽

2019 ◽

Vol 131 (6) ◽

pp. 1931-1937 ◽

Cited By ~ 2

Author(s):

Sungho Lee ◽

Hyunsoo Hwang ◽

Jose-Miguel Yamal ◽

J. Clay Goodman ◽

Imoigele P. Aisiku ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Organ Dysfunction ◽

Multiple Organ Dysfunction Syndrome ◽

Sofa Score ◽

Plasma Concentrations ◽

Multiple Organ ◽

Multiple Organ Dysfunction ◽

Poor Outcome ◽

Initial Plasma

OBJECTIVETraumatic brain injury (TBI) is a major cause of morbidity and mortality. Multiple organ dysfunction syndrome (MODS) occurs frequently after TBI and independently worsens outcome. The present study aimed to identify potential admission characteristics associated with post-TBI MODS.METHODSThe authors performed a secondary analysis of a recent randomized clinical trial studying the effects of erythropoietin and blood transfusion threshold on neurological recovery after TBI. Admission clinical, demographic, laboratory, and imaging parameters were used in a multivariable Cox regression analysis to identify independent risk factors for MODS following TBI, defined as maximum total Sequential Organ Failure Assessment (SOFA) score > 7 within 10 days of TBI.RESULTSTwo hundred patients were initially recruited and 166 were included in the final analysis. Respiratory dysfunction was the most common nonneurological organ system dysfunction, occurring in 62% of the patients. International Mission for Prognosis and Analysis of Clinical Trials (IMPACT) probability of poor outcome at admission was significantly associated with MODS following TBI (odds ratio [OR] 8.88, 95% confidence interval [CI] 1.94–42.68, p < 0.05). However, more commonly used measures of TBI severity, such as the Glasgow Coma Scale, Injury Severity Scale, and Marshall classification, were not associated with post-TBI MODS. In addition, initial plasma concentrations of interleukin (IL)–6, IL-8, and IL-10 were significantly associated with the development of MODS (OR 1.47, 95% CI 1.20–1.80, p < 0.001 for IL-6; OR 1.26, 95% CI 1.01–1.58, p = 0.042 for IL-8; OR 1.77, 95% CI 1.24–2.53, p = 0.002 for IL-10) as well as individual organ dysfunction (SOFA component score ≥ 1). Finally, MODS following TBI was significantly associated with mortality (OR 5.95, 95% CI 2.18–19.14, p = 0.001), and SOFA score was significantly associated with poor outcome at 6 months (Glasgow Outcome Scale score < 4) when analyzed as a continuous variable (OR 1.21, 95% CI 1.06–1.40, p = 0.006).CONCLUSIONSAdmission IMPACT probability of poor outcome and initial plasma concentrations of IL-6, IL-8, and IL-10 were associated with MODS following TBI.

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