Correction: Ou et al. Bone Healing and Regeneration Potential in Rabbit Cortical Defects Using an Innovative Bioceramic Bone Graft Substitute. Appl. Sci. 2020, 10, 6239

The purpose of thehttp://mts.hindawi.com/update/) in our Manuscript Tracking System and after you have logged in click on the ORCID link at the top of the page. This link will take you to the ORCID website where you will be able to create an account for yourself. Once you have done so, your new ORCID will be saved in our Manuscript Tracking System automatically."?> present study was to investigate the effect of local hydroxyapatite (HA) combined with extracted sea cucumber (Stichopus hermanni) collagen as a promising bone graft substitute on bone remodeling. Fourier-transform infrared spectroscopy, X-ray diffractometry, transmission electron microscopy, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and Sprague-Dawley rat model were used to characterize the microstructure, in vitro cytotoxicity, and in vivo bone-healing properties of the investigated biocomposite material. Analytical results found that the hydrothermal reaction-synthesized local HA had a hexagonal close-packed structure. The addition of extracted S. hermanni collagen did not influence the microstructure and functional groups of the local HA. Moreover, the MTT assay indicated that the investigated biocomposite material possessed a good in vitro biocompatibility. The in vivo animal study also revealed that the investigated biocomposite material exhibited the highest number of osteoblasts after 14 days of healing. Therefore, the results demonstrate that the local HA combined with extracted S. hermanni collagen could potentially enhance osteoblast formation in promoting bone healing and regeneration.

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No effect of Osteoset ® , a bone graft substitute, on bone healing in humans: A prospective randomized double-blind study

Acta Orthopaedica Scandinavica ◽

10.1080/000164702321022875 ◽

2002 ◽

Vol 73 (5) ◽

pp. 575-578 ◽

Cited By ~ 35

Author(s):

Juozas Petruskevicius ◽

Strange Nielsen ◽

Søren Kaalund ◽

Preben R Knudsen ◽

Søren Overgaard

Keyword(s):

Bone Graft ◽

Bone Healing ◽

Bone Graft Substitute ◽

Blind Study ◽

Double Blind Study ◽

Double Blind

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Size matters: Effect of granule size of the bone graft substitute (Herafill®) on bone healing using Masquelet's induced membrane in a critical size defect model in the rat's femur

Journal of Biomedical Materials Research Part B Applied Biomaterials ◽

10.1002/jbm.b.34495 ◽

2020 ◽

Vol 108 (4) ◽

pp. 1469-1482 ◽

Cited By ~ 5

Author(s):

Maximilian Leiblein ◽

Elias Koch ◽

Andreas Winkenbach ◽

Alexander Schaible ◽

Christoph Nau ◽

...

Keyword(s):

Bone Graft ◽

Bone Healing ◽

Critical Size ◽

Bone Graft Substitute ◽

Granule Size ◽

Defect Model ◽

Critical Size Defect ◽

Induced Membrane

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Development and physicochemical characterization of novel porous phosphate glass bone graft substitute and in vitro comparison with xenograft

Journal of Materials Science Materials in Medicine ◽

10.1007/s10856-021-06532-8 ◽

2021 ◽

Vol 32 (6) ◽

Author(s):

Niketa Chauhan ◽

Nilay Lakhkar ◽

Amol Chaudhari

Keyword(s):

Cell Proliferation ◽

Physicochemical Properties ◽

Bone Graft ◽

Phosphate Glass ◽

Physicochemical Characterization ◽

Bone Graft Substitute ◽

Organic Content ◽

In Vitro Cytotoxicity ◽

Porous Phosphate

AbstractThe process of bone regeneration in bone grafting procedures is greatly influenced by the physicochemical properties of the bone graft substitute. In this study, porous phosphate glass (PPG) morsels were developed and their physicochemical properties such as degradation, crystallinity, organic content, surface topography, particle size and porosity were evaluated using various analytical methods. The in vitro cytotoxicity of the PPG morsels was assessed and the interaction of the PPG morsels with Dental Pulp Stem Cells (DPSCs) was studied by measuring cell proliferation and cell penetration depth. The cell-material interactions between PPG morsels and a commercially available xenograft (XG) were compared. The PPG morsels were observed to be amorphous, biocompatible and highly porous (porosity = 58.45%). From in vitro experiments, PPG morsels were observed to be non-cytotoxic and showed better cell proliferation. The internal surface of PPG was easily accessible to the cells compared to XG.

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405 Radiological Analysis of Gentamicin Eluting Synthetic Bone Graft Substitute Used in The Management of Gustilo IIIB Open Fractures

British Journal of Surgery ◽

10.1093/bjs/znab134.273 ◽

2021 ◽

Vol 108 (Supplement_2) ◽

Author(s):

A Aljawadi ◽

I Madhi ◽

T Naylor ◽

M Elmajee ◽

A Islam ◽

...

Keyword(s):

Bone Graft ◽

Cortical Thickness ◽

Bone Graft Substitute ◽

Fracture Site ◽

Open Fractures ◽

X Rays ◽

Radiographic Images ◽

Synthetic Bone ◽

Synthetic Bone Graft

Abstract Background Management of traumatic bone void associated with Gustilo IIIB open fractures is challenging. Gentamicin eluting synthetic bone graft substitute (Cerament-G) had been recently utilised for the management of patients with these injuries. This study aims to assess radiological signs of Cerament-G remodelling. Method Retrospective data analysis of all patients admitted to our unit with IIIB open fractures who had Cerament-G applied as avoid filler. Postoperative radiographic images of the fracture site at 6-weeks, 3-months, 6-months and at the last follow-up were reviewed. The radiological signs of Cerament-G integration, percent of void healing, and bone cortical thickness at the final follow-up were assessed. Results 34 patients met our inclusion criteria, mean age: 42 years. Mean follow-up time was 20 months. 59% of patients had excellent (>90%) void filling, 26.4% of patients had 50-90% void filling, and 14.6% had < 50% void filling. Normal bone cortical thickness was restored on AP and Lateral views in 55.8% of patients. No residual Cerement-G was seen on X-rays at the final follow-up in any of the patients. Conclusions Our results showed successful integration of Cerament-G with excellent void filling and normal cortical thickness achieved in more than half of the patients.

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