Characterization of Chlorhexidine-Loaded Calcium-Hydroxide Microparticles as a Potential Dental Pulp-Capping Material

O objetivo deste estudo é avaliar as propriedades físico-químicas e biológicas dos principais materiais indicados para capeamento pulpar direto. Revisou-se a literatura, nos bancos de dados Pubmed, Scopus e Scielo, entre 2007 e 2017, buscando artigos em português e em inglês, utilizando os descritores combinados: “Dental Pulp Capping”, “Biocompatible Materials” e “Calcium Hydroxide” como estratégia de busca. Foram obtidos 55 artigos em que 21 estavam em repetição e foram excluídos, dos demais 6 eram revisão de literatura, 3 eram ensaios clínicos e 25 estudos laboratoriais. Através de uma leitura crítica dos títulos e dos resumos, foram selecionados 10 artigos segundo sua relevância para o estudo. Os materiais mais relatados foram o hidróxido de cálcio, o agregado trióxido mineral (MTA) e o silicato tricálcio (biodentine®). O primeiro contém propriedades antibacterianas e biocompatibilidade, entretanto possui a sua alta solubilidade como desvantagem. O segundo apresenta resultados mais previsíveis que o primeiro na formação da barreira dentinária, melhor biocompatibilidade e boa capacidade seladora. O terceiro mostra maior formação de dentina terciária, promovendo um bom selamento marginal e mostra a menor solubilidade entre eles. Assim, os materiais MTA e biodentine mostram-se materiais viáveis ao tradicional hidróxido de cálcio.Palavras-chave: Dental Pulp Capping. Biocompatible Materials. Calcium Hydroxide.

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NOS Evaluations in Human Dental Pulp-Capping with MTA and Calcium-Hydroxide

International Journal of Immunopathology and Pharmacology ◽

10.1177/039463200702001s07 ◽

2007 ◽

Vol 20 (1_suppl) ◽

pp. 27-32 ◽

Cited By ~ 6

Author(s):

C. D'arcangelo ◽

F. Di Nardo-Di Maio ◽

C. Patrono ◽

S. Caputi

Keyword(s):

Calcium Hydroxide ◽

Dental Pulp ◽

Pulp Capping ◽

Dental Pulp Capping ◽

Human Dental Pulp

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Dental Stem Cell Therapy with Calcium Hydroxide in Dental Pulp Capping

Tissue Engineering Part A ◽

10.1089/ten.tea.2009.0054 ◽

2010 ◽

Vol 16 (6) ◽

pp. 1823-1833 ◽

Cited By ~ 57

Author(s):

Young-Min Ji ◽

Soung Hoo Jeon ◽

Joo-Young Park ◽

Jong-Hoon Chung ◽

Yun-Hoon Choung ◽

...

Keyword(s):

Stem Cell ◽

Cell Therapy ◽

Calcium Hydroxide ◽

Stem Cell Therapy ◽

Dental Pulp ◽

Pulp Capping ◽

Dental Pulp Capping ◽

Dental Stem Cell

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Nanoscale chemical surface characterization of four different types of dental pulp-capping materials

Journal of Dentistry ◽

10.1016/j.jdent.2016.12.009 ◽

2017 ◽

Vol 58 ◽

pp. 11-18 ◽

Cited By ~ 13

Author(s):

Victor Gong ◽

Rodrigo França

Keyword(s):

Dental Pulp ◽

Surface Characterization ◽

Chemical Surface ◽

Pulp Capping ◽

Dental Pulp Capping ◽

Different Types

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Comparison of Four Dental Pulp-Capping Agents by Cone-Beam Computed Tomography and Histological Techniques—A Split-Mouth Design Ex Vivo Study

Applied Sciences ◽

10.3390/app11073045 ◽

2021 ◽

Vol 11 (7) ◽

pp. 3045

Author(s):

Jayanandan Muruganandhan ◽

Govindarajan Sujatha ◽

Saravanan Poorni ◽

Manali Ramakrishnan Srinivasan ◽

Nezar Boreak ◽

...

Keyword(s):

Computed Tomography ◽

Calcium Hydroxide ◽

Cone Beam Computed Tomography ◽

Dental Pulp ◽

Cone Beam ◽

Capping Agents ◽

Bridge Formation ◽

Pulp Capping ◽

Dental Pulp Capping ◽

Post Hoc

Dental pulp-capping is done to preserve vital teeth when the pulp is exposed due to caries, trauma or instrumentation. Various materials are used as pulp-capping agents. The introduction of newer materials requires scientific studies to assess their clinical efficacy. The study was designed as a split-mouth randomized analysis of four pulp-capping agents (calcium hydroxide, mineral trioxide aggregate (MTA), Biodentine and EndoSequence root repair material (ERRM)). Based on selection criteria, 15 orthodontic patients requiring the extraction of four premolars (60 teeth total) were included in the study. After pulp-capping, the teeth were extracted after 8 weeks. We analyzed the extracted teeth using cone-beam computed tomography (CBCT) and histological sections to determine the quality of the dentinal bridge and the pulpal response. Ordinal scores were given based on the completeness of the dentinal bridge, the type of bridge and the degree of pulpal inflammation. Results were analyzed using a Kruskal–Wallis test (p < 0.05) with post hoc Conover values being used when applicable. All four pulp-capping materials elicited dentinal bridge formation (60/60). MTA had the highest scores (10/15) in dentinal bridge formation followed by ERRM (8/15). Both materials showed more samples with complete dentinal bridges (9/15 each) and a favorable pulpal response (15/15). Teeth capped with calcium hydroxide showed more cases of incomplete bridge formation (9/15) and pulpal inflammation. These differences in dentinal bridge formation and pulpal inflammation were statistically significant (p 0.001 and p 0.00005, respectively), with post hoc tests revealing no significant differences between MTA and ERRM (p 0.49 and p 0.71, respectively). MTA and ERRM performed better than the other pulp-capping materials but did not differ significantly from each other. The individual preference for a pulp-capping material may be based on clinical efficacy and handling characteristics.

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Avaliação da Adesão, Sorção de Água e Solubilidade de Resinas Compostas Autoadesivas Experimentais para Capeamento Pulpar Direto

Journal of Health Sciences ◽

10.17921/2447-8938.2017v19n5p102 ◽

2018 ◽

Vol 19 (5) ◽

pp. 102

Author(s):

J C Silva ◽

A E C Ferreira-Júnior ◽

P G B Silva ◽

A P N Nunes Alves ◽

M R L Mota ◽

...

Keyword(s):

Calcium Hydroxide ◽

Dental Pulp ◽

Pulp Capping ◽

Dental Pulp Capping ◽

Push Out

O objetivo foi analisar resinas compostas experimentais para capeamento pulpar direto em propriedades físico-químicas selecionadas, comparando com hidróxido de cálcio fotopolimerizável e MTA. Duas resinas compostas capeadoras foram preparadas, uma sem adição de partículas bioativas (controle) e a outra com 30% em peso (experimental) de nanopartículas de hidroxiapatita adsorvidas com sinvastatina (10%), com glutationa (10%) e de beta fosfato tricálcio (10%). Foram utilizados 36 terceiros molares hígidos extraídos, onde foi realizado preparo cavitário na região coronária até atingir a câmara pulpar para posterior restauração com um dos materiais. Os espécimes foram cortados em fatias (1mm) e essas foram submetidas ao teste de resistência de união ao push-out. Espécimes em forma de disco (n8) foram preparados e avaliados (ISO4049) quanto a sorção e solubilidade. A análise estatística foi feita com ANOVA e teste de Tukey (a5%). Os resultados de resistência de união mostraram que o MTA e o hidróxido de cálcio apresentaram pior adesão do que as resinas, e os maiores valores foram obtidos com a resina experimental (p<0,05). Maior sorção de água foi observada com o hidróxido de cálcio e os demais materiais não apresentaram diferenças estatísticas. O hidróxido de cálcio obteve maior solubilidade que a resina controle e a experimental (p<0,05). Em conclusão, a resina experimental com partículas bioativas promove maior adesão à dentina e menor sorção e solubilidade que hidróxido de cálcio e MTA, esses materiais que são tradicionalmente usados para capeamento pulpar.Palavras-chave: Dental Pulp Capping. Simvastatin Calcium Hydroxide.

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Effect of five dental pulp capping agents on cell proliferation, viability, apoptosis and mineralization of human dental pulp cells

Experimental and Therapeutic Medicine ◽

10.3892/etm.2020.8444 ◽

2020 ◽

Cited By ~ 1

Author(s):

Lei Dou ◽

Qifang Yan ◽

Deqin Yang

Keyword(s):

Cell Proliferation ◽

Dental Pulp ◽

Dental Pulp Cells ◽

Capping Agents ◽

Human Dental Pulp Cells ◽

Pulp Capping ◽

Dental Pulp Capping ◽

Human Dental Pulp ◽

Pulp Cells

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Evaluation of Resin-Based Material Containing Copaiba Oleoresin (Copaifera Reticulata Ducke): Biological Effects on the Human Dental Pulp Stem Cells

Biomolecules ◽

10.3390/biom10070972 ◽

2020 ◽

Vol 10 (7) ◽

pp. 972

Author(s):

Roberta Souza D’Almeida Couto ◽

Maria Fernanda Setubal Destro Rodrigues ◽

Leila Soares Ferreira ◽

Ivana Márcia Alves Diniz ◽

Fernando de Sá Silva ◽

...

Keyword(s):

Stem Cells ◽

Dental Pulp ◽

Biological Effects ◽

Dental Pulp Stem Cells ◽

Nodule Formation ◽

Alizarin Red ◽

Pulp Capping ◽

Hsp 27 ◽

Dental Pulp Capping ◽

Human Dental Pulp

The purpose of this study was to analyze in vitro the biological effects on human dental pulp stem cells triggered in response to substances leached or dissolved from two experimental cements for dental pulp capping. The experimental materials, based on extracts from Copaifera reticulata Ducke (COP), were compared to calcium hydroxide [Ca(OH)2] and mineral trioxide aggregate (MTA), materials commonly used for direct dental pulp capping in restorative dentistry. For this, human dental pulp stem cells were exposed to COP associated or not with Ca(OH)2 or MTA. Cell cytocompatibility, migration, and differentiation (mineralized nodule formation (Alizarin red assay) and gene expression (RT-qPCR) of OCN, DSPP, and HSP-27 (genes regulated in biomineralization events)) were evaluated. The results showed that the association of COP reduced the cytotoxicity of Ca(OH)2. Upregulations of the OCN, DSPP, and HSP-27 genes were observed in response to the association of COP to MTA, and the DSPP and HSP-27 genes were upregulated in the Ca(OH)2 + COP group. In up to 24 h, cell migration was significantly enhanced in the MTA + COP and Ca(OH)2 + COP groups. In conclusion, the combination of COP with the currently used materials for dental pulp capping [Ca(OH)2 and MTA] improved the cell activities related to pulp repair (i.e., cytocompatibility, differentiation, mineralization, and migration) including a protective effect against the cytotoxicity of Ca(OH)2.

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