scholarly journals Synthesis and Characterization of FITC Labelled Ruthenium Dendrimer as a Prospective Anticancer Drug

Biomolecules ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 411 ◽  
Author(s):  
Sylwia Michlewska ◽  
Małgorzata Kubczak ◽  
Marta Maroto-Díaz ◽  
Natalia Sanz del Olmo ◽  
Paula Ortega ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Chemical Sensors ◽  
Cytotoxic Effect ◽  
Fluorescein Isothiocyanate ◽  
Synthesis And Characterization ◽  
Normal Cells ◽  
Anticancer Effects ◽  
Porphyrin Core

Metallodendrimers—dendrimers with included metals—are widely investigated as biocompatible equivalents to metal nanoparticles. Applications can be expected in the fields of catalysis, as chemical sensors in molecular recognition and as anticancer drugs. Metallodendrimers can also mimic certain biomolecules, for example, haemoprotein in the case of using a dendrimer with a porphyrin core. In previous papers, we showed the promising anticancer effects of carbosilane ruthenium dendrimers. The present paper is devoted to studying biocompatibility and the cytotoxic effect on normal and cancer cells of carbosilane ruthenium dendrimers labelled with fluorescent probe fluorescein isothiocyanate (FITC). The addition of fluorescent probe allowed tracking the metallodendrimer in both normal and cancer cells. It was found that carbosilane ruthenium dendrimer labelled with FITC in concentration up to 10 µmol/L was more cytotoxic for cancer cells than for normal cells. Thus, FITC labelled carbosilane ruthenium dendrimer is a good candidate for diagnostic imaging and studying anticancer effects of metallodendrimers in cancer therapy.

scholarly journals Synthesis and characterization of novel protein nanodots as drug delivery carriers with an enhanced biological efficacy of melatonin in breast cancer cells

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9076-9085
Author(s):  
Kanchan Yadav ◽  
Megha Das ◽  
Nurul Hassan ◽  
Archana Mishra ◽  
Jayeeta Lahiri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Live Cell Imaging ◽  
Biomedical Applications ◽  
Breast Cancer Cells ◽  
Cell Imaging ◽  
Synthesis And Characterization ◽  
Novel Protein

A novel nanodot-using protein has been synthesized for the live cell imaging and drug delivery of melatonin in breast cancer cells. Its unique properties hold potential for various biomedical applications in the field of bioimaging and drug delivery.

Synthesis and characterization of periphery-functionalized porphyrazines containing mixed pyrrolyl and pyridylmethylamino groups

2009 ◽  
Vol 13 (02) ◽  
pp. 223-234 ◽  
Author(s):  
Tomasz Goslinski ◽  
Ewa Tykarska ◽  
Wojciech Szczolko ◽  
Tomasz Osmalek ◽  
Aleksandra Smigielska ◽  
...  
Keyword(s):  
Electrochemical Properties ◽  
Chemical Sensors ◽  
Electronic Materials ◽  
Condensation Reaction ◽  
Synthesis And Characterization ◽  
X Ray ◽  
Coordination Properties ◽  
Perpendicular Orientation ◽  
Selective Sensor

The condensation reaction of 2-amino-3-[(3-pyridylmethyl)amino]-2(Z)-butene-1,4-dinitrile with a series of diketones led to novel dinitriles, of which 2-(2,5-dimethyl-1H-pyrrol-1-yl)-3-[methyl(3-pyridylmethylene)amino]-2(Z)-butene-1,4-dinitrile, the product of the Paal-Knorr reaction, was successfully utilized in the Linstead macrocyclization towards symmetrical and unsymmetrical porphyrazines. NMR and X-ray study revealed an almost perpendicular orientation of the pyrrolyl groups in relation to the porphyrazine platform. The newly synthesized macrocycles with different peripheral groups show interesting spectroscopic and electrochemical properties. Due to selective sensor/coordination properties they are expected to find applications as chemical sensors and electronic materials.

scholarly journals Synthesis and Characterization of a Fluorescent Probe Based on Schiff-Base

Daxue Huaxue ◽  
2020 ◽  
Vol 35 (2) ◽  
pp. 70-74
Author(s):  
Changyan Sun ◽  
◽  
Wenjun Li ◽  
Huili Lu
Keyword(s):  
Schiff Base ◽  
Fluorescent Probe ◽  
Synthesis And Characterization

Synthesis and characterization of folic acid-chitosan nanoparticles loaded with thymoquinone to target ovarian cancer cells

2020 ◽  
Vol 324 (1) ◽  
pp. 71-85
Author(s):  
İskender İnce ◽  
Yeliz Yıldırım ◽  
Günnur Güler ◽  
Emin İlker Medine ◽  
Gülşah Ballıca ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Folic Acid ◽  
Cancer Cells ◽  
Chitosan Nanoparticles ◽  
Synthesis And Characterization ◽  
Ovarian Cancer Cells

A fluorescent probe for simultaneously sensing NTR and hNQO1 and distinguishing cancer cells

2019 ◽  
Vol 7 (43) ◽  
pp. 6822-6827 ◽  
Author(s):  
Fanpeng Kong ◽  
Ying Li ◽  
Chao Yang ◽  
Xiao Li ◽  
Junlin Wu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Normal Cells

A dual-enzyme-responsive probe, CNN, was rationally designed and synthesized for differentiating cancer cells from normal cells owing to the existence of relatively high endogenous levels of both biomarkers in cancer cells.

A novel water-soluble fluorescent probe with ultra-sensitivity over a wider pH range and its application for differentiating cancer cells from normal cells

The Analyst ◽  
2019 ◽  
Vol 144 (23) ◽  
pp. 6975-6980 ◽  
Author(s):  
Zilu Li ◽  
Chen Yu ◽  
Yanan Chen ◽  
Zihan Zhuang ◽  
Bin Tian ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Water Soluble ◽  
Normal Cells ◽  
Ph Range

A water-soluble fluorescent probe with ultra-sensitivity over a wider pH range was developed to differentiate cancer cells from normal cells.

scholarly journals Synthesis and characterization of pectin derivative with antitumor property against Caco-2 colon cancer cells

2015 ◽  
Vol 115 ◽  
pp. 139-145 ◽  
Author(s):  
Elizângela A.M.S. Almeida ◽  
Suelen P. Facchi ◽  
Alessandro F. Martins ◽  
Samara Nocchi ◽  
Ivânia T.A. Schuquel ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Synthesis And Characterization ◽  
Colon Cancer Cells ◽  
Antitumor Property
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