scholarly journals Gamma-Range Auditory Steady-State Responses and Cognitive Performance: A Systematic Review

2021 ◽  
Vol 11 (2) ◽  
pp. 217
Author(s):  
Vykinta Parciauskaite ◽  
Jovana Bjekic ◽  
Inga Griskova-Bulanova
Keyword(s):  
Steady State ◽  
Developmental Disorders ◽  
Short Term Memory ◽  
Oscillatory Activity ◽  
State Response ◽  
Gamma Range ◽  
Auditory Steady State Response ◽  
Wide Range ◽  
Steady State Responses ◽  
Auditory Steady State Responses

The auditory steady-state response (ASSR) is a result of entrainment of the brain’s oscillatory activity to the frequency and phase of temporally modulated stimuli. Gamma-range ASSRs are utilized to observe the dysfunctions of brain-synchronization abilities in neuropsychiatric and developmental disorders with cognitive symptoms. However, the link between gamma-range ASSRs and cognitive functioning is not clear. We systematically reviewed existing findings on the associations between gamma-range ASSRs and cognitive functions in patients with neuropsychiatric or developmental disorders and healthy subjects. The literature search yielded 1597 articles. After excluding duplicates and assessing eligibility, 22 articles were included. In healthy participants, the gamma-range ASSR was related to cognitive flexibility and reasoning as measured by complex tasks and behavioral indicators of processing speed. In patients with schizophrenia, the studies that reported correlations found a higher ASSR to be accompanied by better performance on short-term memory tasks, long-term/semantic memory, and simple speeded tasks. The main findings indicate that individual differences in the gamma-range ASSR reflect the level of attentional control and the ability to temporary store and manipulate the information, which are necessary for a wide range of complex cognitive activities, including language, in both healthy and impaired populations.

scholarly journals Effects of restricting maximum possible intensity on auditory steady-state responses

2019 ◽  
Author(s):  
Majid Haddadi Aval ◽  
Sadegh Jafarzadeh
Keyword(s):  
Steady State ◽  
Mean Value ◽  
Profound Hearing Loss ◽  
Auditory Thresholds ◽  
Hearing Sensitivity ◽  
Additional Information ◽  
State Response ◽  
Auditory Steady State Response ◽  
Steady State Responses ◽  
Auditory Steady State Responses

Background and Aim: Auditory steady-state response (ASSR) has widespread usage in the clinical hearing assessment of infants and young children. The present study evaluated the effect of restricting maximum possible intensity to 100 dB HL on ASSR thresholds. Methods: This retrospective study was conduc­ted in multiple audiology centers. ASSR thre­sholds with restricted settings were evaluated in 58 infants (116 ears). They had absent otoaco­ustic emissions and click-evoked auditory bra­instem response waveforms and bilateral severe to profound hearing loss in behavioral evalu­ations. Results: ASSR thresholds were absent in 28%, 25%, 60%, and 70% of ears in 500, 1000, 2000, and 4000 Hz, respectively. The mean value of remained thresholds was approximately 90−95 dB HL. Conclusion: Restricted ASSR settings are pre­valent; however, they fail to provide extensive additional information about hearing sensitivity. Thus, manufacturers are suggested to improve ASSR setting and transducers and resolve the intensity restrictions. ASSR settings should be able to test auditory thresholds to level of 120 dB HL.

scholarly journals Σύγκριση των click Auditory Brainstem Responses (ABR) και των chirp Auditory Steady-State Responses (ASSR), ηλεκτροφυσιολογικών (αντικειμενικών) μεθόδων που χρησιμοποιούνται για τον έλεγχο και τη διάγνωση της παιδικής βαρηκοΐας

2021 ◽  
Author(s):  
Κωνσταντίνος Μουρτζούχος
Keyword(s):  
Steady State ◽  
Tone Burst ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
State Response ◽  
Auditory Steady State Response ◽  
Brainstem Response ◽  
Steady State Responses ◽  
Auditory Steady State Responses ◽  
State Responses

Τα προκλητά δυναμικά κατέχουν σημαντική θέση στον προσδιορισμό των ουδών της ακοής σε παιδιά πολύ μικρά για να εξεταστούν με τις συμβατικές συμπεριφορικές μεθόδους και σε άλλους πληθυσμούς που παρουσιάζουν δυσκολίες κατά την εξέταση. Το ABR (Auditory Brainstem Response), μέθοδος που χρησιμοποιείται κατά τα τελευταία 50 χρόνια, έχει σήμερα ευρέως αναγνωριστεί ως η πιο αποτελεσματική τεχνική προκλητών δυναμικών και χρησιμοποιείται καθημερινά, με click και tone burst ως ερεθίσματα, για την εκτίμηση της ακουστικής ικανότητας σε βρέφη και παιδιά πολύ μικρά για άλλες εξεταστικές μεθόδους. Η καταγραφή του ABR, ωστόσο, υπόκειται σε περιορισμούς ως προς το ανώτερο επίπεδο έντασης χορήγησης του ερεθίσματος, όπως επίσης και εξαιτίας της υποκειμενικής μεθόδου ελέγχου για τον προσδιορισμό του ουδού, ενώ οι καταγραφές με tone burst ερεθίσματα είναι συχνά πιο απαιτητικές ως προς την ερμηνεία τους, λόγω του ότι οι κυματομορφές μπορεί να είναι λιγότερο χαρακτηριστικές. Το ASSR (Auditory Steady-State Response) αποτελεί μια πιο πρόσφατη εναλλακτική πρόταση έναντι των καθιερωμένων ABR τεχνικών καταγραφής. Σε αντίθεση με το παροδικού τύπου ερέθισμα click που χρησιμοποιείται στις ABR καταγραφές, το διαμορφωμένο συνεχούς τύπου ερέθισμα του ASSR εκλύει μια περιοδική ή “steady-state” κυματομορφή, της οποίας τα φασματικά χαρακτηριστικά (εύρος και φάση) αναλύονται στο frequency ή και στο time domain για τον προσδιορισμό της παρουσίας ή της απουσίας απάντησης. Το αυτόματο σύστημα ανίχνευσης της απάντησης που χρησιμοποιείται στην καταγραφή του ASSR εξαλείφει την ανάγκη για υποκειμενικό τρόπο ελέγχου των απαντήσεων. Ο τύπος του ASSR ερεθίσματος που χρησιμοποιήθηκε σε αυτήν την μελέτη ήταν το narrowband CE-chirp, ένα είδος chirp που εισήλθε σχετικά πολύ πρόσφατα στις συσκευές που διατίθενται στο εμπόριο. Σκοπός αυτής της μελέτης ήταν να συγκρίνει αυτές τις δύο ηλεκτροφυσιολογικές μεθόδους και τον βαθμό στον οποίο συσχετίζονται, σε ένα μεγάλο πληθυσμό παιδιών με διάφορου βαθμού νευροαισθητήρια βαρηκοΐα, που εξετάστηκαν με φαρμακευτικό ύπνο στο Ακοολογικό Κέντρο της Κλινικής μας κατά το διάστημα 2010-14. Εξετάστηκαν συνολικά 130 παιδιά, 90 άρρενα και 40 θήλεα (n = 260 αυτιά), ηλικίας 5 έως 79 μηνών (μέση ηλικία: 32.7 ± 14.0 μήνες), με μια ποικιλία προβλημάτων και διαταραχών. Η τελική στατιστική ανάλυση για σύγκριση των δύο μεθόδων περιέλαβε αφ’ ενός τις τιμές ουδών που αποκτήθηκαν από το click ABR και αφ’ ετέρου τους μέσους όρους των ουδών που αποκτήθηκαν από το chirp ASSR στις συχνότητες 1, 2 και 4 kHz και 2 και 4 kHz. Τα αποτελέσματα αυτής της μελέτης ανέδειξαν ισχυρές συσχετίσεις μεταξύ των click ABR ουδών και των μέσων όρων των chirp ASSR ουδών στα 1000, 2000 και 4000 Hz (rs = .826, p < .001) και στα 2000 και 4000 Hz (rs = .824, p < .001) και συμφωνούν γενικά με τα αποτελέσματα παρόμοιων μελετών της διεθνούς βιβλιογραφίας. Συμπερασματικά φαίνεται ότι το ASSR είναι αναγκαίο για την ακριβή ποσοτικοποίηση της υπολειπόμενης ακοής στην ζώνη της μεγάλου προς πολύ μεγάλου βαθμού βαρηκοΐας, σε περιοχές εντάσεων άνω των ορίων των περισσοτέρων ABR συσκευών. Η «ακοολογική πληροφορία» που αποκτάται με το ASSR τεστ, ειδικά στην ανωτέρω περιοχή, είναι πολύτιμη στην λήψη αποφάσεων για περαιτέρω παρέμβαση σε παιδιά με νευροαισθητήρια βαρηκοΐα (ενίσχυση, κοχλιακή εμφύτευση), ιδίως για τα παιδιά εκείνα που δεν μπορούν να μετρηθούν με συμπεριφορικές μεθόδους. Τα αποτελέσματα αυτά ενισχύουν την χρήση του ASSR ως εναλλακτικού τεστ σε σχέση με το ABR στην εκτίμηση και αντιμετώπιση της παιδικής βαρηκοΐας.

scholarly journals Improving source modeling of auditory steady-state responses with frequency-specific brain maps

2019 ◽  
Author(s):  
Ehsan Darestani Farahani ◽  
Jan Wouters ◽  
Astrid van Wieringen
Keyword(s):  
Steady State ◽  
Primary Sources ◽  
Source Modeling ◽  
High Modulation ◽  
Wide Range ◽  
Steady State Responses ◽  
Consistent Picture ◽  
Auditory Steady State Responses ◽  
Group Ica ◽  
State Responses

AbstractAuditory steady-state responses (ASSRs) are evoked brain responses to modulated or repetitive acoustic stimuli. Due to a wide range of clinical and research applications, there is a great (clinical) interest to investigate the underlying neural generators of ASSRs. The cortical sources of ASSRs mostly are located in the auditory cortex (AC), although some studies avoiding prior assumptions regarding the number and location of the sources have also reported activity of sources outside of the AC. However, little is known about the number and location of these sources. In this study, we present a novel extension to minimum-norm imaging (MNI) which facilitates ASSR source reconstruction and provides a comprehensive and consistent picture of sources in response to low- as well as high modulation frequencies, monaurally presented to the left and right ears.Results demonstrate that the proposed MNI approach is successful in reconstructing sources located both within (primary) and outside (non-primary) of the AC. The locations of the non-primary sources are consistent with the literature. Primary sources are detected in every experimental condition, thereby corroborating the robustness of the approach. Moreover, we show that the MNI approach is capable of reconstructing the subcortical activities of ASSRs. In summary, the results indicate that the MNI approach outperforms the previously used method of group-ICA, in terms of detection of sources in the AC, reconstructing the subcortical activities and reducing computational load.

Normal Multiple Auditory Steady-State Response Thresholds to Air-Conducted Stimuli in Infants

2009 ◽  
Vol 20 (03) ◽  
pp. 196-207 ◽  
Author(s):  
Anna Van Maanen ◽  
David R. Stapells
Keyword(s):  
Steady State ◽  
Age Groups ◽  
Normal Hearing ◽  
Auditory Brain Stem Response ◽  
Auditory Brain Stem ◽  
Auditory Steady State Response ◽  
Threshold Assessment ◽  
Multiple Stimulus ◽  
Steady State Responses ◽  
Auditory Steady State Responses

Background and Purpose: Multiple auditory steady-state responses (ASSRs) to stimuli modulated at ˜80 Hz are a promising technique for threshold estimation in infants, but additional data are required. Research Design: We obtained multiple ASSRs to air-conducted (AC) stimuli. Study Sample: There were 54 children in two age groups: >six months (N = 32) and ≤six months (N = 22). All infants had normal hearing by tone-evoked auditory brain stem response. Results: ASSR thresholds, estimated from 50 percent using cumulative percent present distributions, were 36, 30, 24, and 15 dB HL at 500, 1000, 2000, and 4000 Hz, respectively. Most (≥90%) of the infants showed present ASSRs at 49, 45, 36, and 32 dB HL at 500, 1000, 2000, and 4000 Hz, respectively, with no differences in the results of younger versus older infants. When responses were present for all stimuli for both ears, most infants showed all eight responses within five minutes. Compared to ipsilateral responses, ASSRs in the contralateral EEG (electroencephalogram) channel were smaller and often absent. Conclusions: Based upon these data and the literature, normal AC ASSR “screening” levels would be 50, 45, 40, and 40 dB HL at 500, 1000, 2000, and 4000 Hz, respectively. Using the multiple-stimulus ASSR, infants with normal hearing referred for diagnostic electrophysiological threshold assessment can now be quickly confirmed as having normal thresholds for four frequencies in both ears.

scholarly journals The Role of Parvalbumin-positive Interneurons in Auditory Steady-State Response Deficits in Schizophrenia

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Christoph Metzner ◽  
Bartosz Zurowski ◽  
Volker Steuber
Keyword(s):  
Steady State ◽  
Therapeutic Interventions ◽  
Steady State Response ◽  
State Response ◽  
Basket Cells ◽  
Gamma Range ◽  
Auditory Steady State Response ◽  
Synaptic Dynamics ◽  
Chandelier Cells

AbstractDespite an increasing body of evidence demonstrating subcellular alterations in parvalbumin-positive (PV+) interneurons in schizophrenia, their functional consequences remain elusive. Since PV+ interneurons are involved in the generation of fast cortical rhythms, these changes have been hypothesized to contribute to well-established alterations of beta and gamma range oscillations in patients suffering from schizophrenia. However, the precise role of these alterations and the role of different subtypes of PV+ interneurons is still unclear. Here we used a computational model of auditory steady-state response (ASSR) deficits in schizophrenia. We investigated the differential effects of decelerated synaptic dynamics, caused by subcellular alterations at two subtypes of PV+ interneurons: basket cells and chandelier cells. Our simulations suggest that subcellular alterations at basket cell synapses rather than chandelier cell synapses are the main contributor to these deficits. Particularly, basket cells might serve as target for innovative therapeutic interventions aiming at reversing the oscillatory deficits.

scholarly journals The Role of Parvalbumin-positive Interneurons in Auditory Steady-State Response Deficits in Schizophrenia

2019 ◽  
Author(s):  
Christoph Metzner ◽  
Bartosz Zurowski ◽  
Volker Steuber
Keyword(s):  
Steady State ◽  
Therapeutic Interventions ◽  
Steady State Response ◽  
State Response ◽  
Basket Cells ◽  
Gamma Range ◽  
Auditory Steady State Response ◽  
Synaptic Dynamics ◽  
Chandelier Cells

AbstractDespite an increasing body of evidence demonstrating subcellular alterations in parvalbumin-positive (PV+) interneurons in schizophrenia, their functional consequences remain elusive. Since PV+ interneurons are involved in the generation of fast cortical rhythms, these changes have been hypothesized to contribute to well-established alterations of beta and gamma range oscillations in patients suffering from schizophrenia. However, the precise role of these alterations and the role of different subtypes of PV+ interneurons is still unclear. Here we used a computational model of auditory steady-state response (ASSR) deficits in schizophrenia. We investigated the differential effects of decelerated synaptic dynamics, caused by subcellular alterations at two subtypes of PV+ interneurons: basket cells and chandelier cells. Our simulations suggest that subcellular alterations at basket cell synapses rather than chandelier cell synapses are the main contributor to these deficits Particularly, basket cells might serve as target for innovative therapeutic interventions aiming at reversing the oscillatory deficits.

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